SCIENTIFIC REPORT

INSTITUTO BIOFISIKA

2015-2016

Edition / Edición / Edizioa: Instituto Biofisika institutua (CSIC, UPV/EHU)

Design and layout / Diseño y maquetación / Diseinua eta maketazioa: Sonia Rueda

Photographs / Fotografías / Argazkiak: AA. VV. Sonia Rueda

Print / Impresión / Inprimaketa: Grafilur. Arte Gráfico

INSTITUTO BIOFISIKA

SCIENTIFIC REPORT

2015-2016

INSTITUTO BIOFISIKA 2015-2016

SCIENTIFIC REPORT INDEX

10.

1. Message from the Director.....................................................................4 2. Foreword/Presentación/Aurkezpena................................................7 3. IBF news..........................................................................................................9 4. IBF milestones...........................................................................................13 5. Awards and honours..............................................................................19 6. Organization...............................................................................................21 6.1. Directive Team and Administration........................................21 6.2. Researchers........................................................................................21 6.2.1. Scientific staff........................................................................21 6.2.2. Postdoctoral associates...................................................23 6.2.3. PhD students........................................................................25 6.2.4. Undergraduate Students................................................27 6.3. Technicians.......................................................................................28 6.4. Reception...........................................................................................29 6.5. Cleaning staff....................................................................................29 6.6. BBF.........................................................................................................297. Scientific highlights.................................................................................31 7.1. PhD Theses.........................................................................................31 7.2. Patents.................................................................................................33 7.3. Publications.......................................................................................34 7.4. Conferences and courses.............................................................50 7.4.1. Organization of meetings...............................................50 7.4.2. Invited talks...........................................................................54 7.4.3. Free communications.......................................................65 7.4.4. BioForo......................................................................................67 7.4.5. Science dissemination......................................................72

7.5. Governing Bodies and Public Service.....................................76 7.6. Scientific Journals and Committees........................................78 7.7. Other activities..................................................................................798. Biophysics Visitors Programme..........................................................819. PhD Thesis at IBF......................................................................................82 IBF in numbers...................................................................................89 Funding................................................................................................92

INSTITUTO BIOFISIKA 2015-2016

SCIENTIFIC REPORT INDEX

3

11.

Time passes quickly when we are doing something we like, but when we stop and look back we realize that it has been two years since we published our latest Scientific Report and important changes and challenges have occurred since then.

In July 2015, the University of the Basque Country (UPV/EHU) and the CSIC entrusted me with the Direction of the Institute. First of all, I would like to recognize the excellent work carried out by the former Director, Prof. Félix M. Goñi.

1. Message from the Director

4

At that time, one of our most immediate challenges was to move to a new building located in the Scientific Park – Campus Leioa, UPV/EHU. This long-awaited goal was finally materialized in February 2016 thanks to the strong and invaluable support from UPV/EHU and CSIC, as well as to the hard work and illusion of all members of our Institute. I strongly believe that people are the greatest value of our Institute, people with knowledge, diligence and passion in the pursuit of professional excellence. Finally, we thank the support and financial assistance provided by the Basque Government and the Biscay County Council, without which this would not have been possible.

At the end of 2015, in accordance with a spirit of continuous improvement, we were evaluated by a group of external experts of recognized prestige, whose recommendations helped us to better organize our research teams and optimize our resources. I would like to take this opportunity to thank all the members of this external committee for their outstanding work and, above all, their support, encouragement and involvement in improving our Institute.

On July 21, 2016, the Scientific Park was officially inaugurated and we had the opportunity to show our facilities and present some of our exciting research projects to political and scientific leaders, during a visit that I remember with pride and gratitude.

We have also changed our name, now “Instituto Biofisika”, in order to better reflect our growing status as a leading research institute, whose mission is to carry out basic and applied research in the field of biophysics and its applications to biotechnology and human health.

Now, we must continue working with determination and enthusiasm in order to conduct rigorous research, effectively disseminate and transfer the findings of this research, train the future generation of scientists in the field of biophysics and its applications, and, finally, serve society in as many ways as we can.

5

The Instituto Biofisika is a joint centre of the Spanish National Research Centre (CSIC) and the University of the Basque Country

(UPV/EHU).

The following pages contain a summary of our research activity during years 2015 and 2016. This report intends to serve a two-fold purpose, providing the reader with information about our activities, and supplying our sponsors with the necessary data about the end-product of their funding. We shall be glad to answer any questions or provide further information, and would be delighted to welcome you personally in our new bulding.

El Instituto Biofisika es un centro mixto del Consejo Superior de Investigaciones Científicas (CSIC) y de la Universidad del País Vasco

(UPV/EHU).

Las páginas que siguen contienen un resumen de nuestra actividad durante los años 2015 y 2016. Esta memoria tiene el doble propósito de proporcionar información sobre nuestras actividades y ofrecer a nuestros patrocinadores los datos necesarios sobre los resultados producto de su generosidad. Con mucho gusto responderemos a cualquier pregunta y facilitaremos información complementaria, y por supuesto estaremos encantados de recibirles en nuestra nueva sede.

Biofisika institutua Consejo Superior de Investigaciones Científicas (CSIC) eta Euskal Herriko Unibertsitateko (UPV/

EHU) zentro bateratua da.

Hurrengo orrietan Biofisika institutuan 2015 eta 2016 urteetan egindako jardueraren berri eskaintzen da. Txosten honek helburu bikoitza du: irakurle orori gure ekintzen berri ematea, eta bereziki, gure laguntzaileei beraien eskuzabaltasunari esker lortutako datuak jakinaraztea. Atsegin handiz, edozein galdera erantzuteko, informazio osagarria eskaintzeko, edota pertsonalki gure egoitza berrian errezibitzeko prest gaude.

2. Foreword/Presentación/Aurkezpena

7

March 27, 2015

A. Alonso was elected as General Secretary of COSCE (Confederación de Sociedades Científicas de España)

(http://www.ehu.eus/es/campusa/kronika/-/asset_publisher/H a 5 M / c o n t e n t / n _ 2 0 1 5 0 4 3 0 _ n o m b r a m i e n t o - a l i c i a -alonso?redirect=http%3A%2F%2Fwww.ehu.eus%2Fes%2Fcampusa%2Fkronika%3Fp_p_id%3D101_INSTANCE_Ha5M%26p_p_lifecycle%3D0%26p_p_state%3Dnormal%26p_p_mode%3Dview%26p_p_col_id%3Dcolumn-1%26p_p_col_count%3D5)

July 14, 2015

The molecular architecture of cell fission processes has been revealed. The research led by scientists in the Biophysics Unit of the UPV/EHU (University of the Basque Country)-CSIC (National Research Council) has been published in Nature

(http://www.ehu.eus/en/en-news/-/asset_publ isher/eFh7/content/20150714_frolov?redirect=http%3A%2F%2Fwww.ehu.eus%2Fen%2Fen-news%3Fp_p_id%3D101_INSTANCE_eFh7%26p_p_lifecycle%3D0%26p_p_state%3Dnormal%26p_p_mode%3Dview%26p_p_col_id%3Dcolumn-2%26p_p_col_count%3D1%26_101_INSTANCE_eFh7_advancedSearch%3Dfalse%26_101_INSTANCE_eFh7_keywords%3D%26_101_INSTANCE_eFh7_delta%3D10%26_101_I N S TA N C E _ e F h 7 _ c u r % 3 D 1 4 % 2 6 _ 1 0 1 _ I N S TA N C E _ e F h 7 _andOperator%3Dtrue)

July 23, 2015

I. Alkorta, Director of the Biophysics Unit

(https://www.ehu.eus/es/campusa/albisteak/-/asset_publisher/R8pu/content/n_20150723-itziar-alkorta-directora-de-la-unidad-de-biofisica?redirect=https%3A%2F%2Fwww.ehu.eus%2Fes%2Fcampusa%2Falbisteak%3Fp_p_id%3D101_INSTANCE_R8pu%26p_p_

3. IBF news

9

lifecycle%3D0%26p_p_state%3Dnormal%26p_p_mode%3Dview%26p_p_col_id%3Dcolumn-1%26p_p_col_count%3D5%26_101_INSTANCE_R8pu_advancedSearch%3Dfalse%26_101_INSTANCE_R8pu_keywords%3D%26_101_INSTANCE_R8pu_delta%3D24%26_101_I N S TA N C E _ R 8 p u _ c u r % 3 D 1 4 % 2 6 _ 1 0 1 _ I N S TA N C E _ R 8 p u _andOperator%3Dtrue, http://www.cicnetwork.es/euskadienbreve/itziar-alkorta-nombrada-directora-de-la-unidad-de-biofisica-el-centro-mixto-del-csic-y-la-upvehu/)

November 3, 2015

F.M. Goñi inaugurates the Zientzia Astea 2015

(http://www.deia.com/2015/11/03/sociedad/euskadi/la-ensenanza-de-ciencias-es-calamitosa)

June 8, 2016

Video for the 5th anniversary of the Chair of Scientific Culture of the UPV/EHU: Pedro Miguel Etxenike, Maddalen Iriarte, Jesus Mari Lazkano, Helena Matute, Antonio Casado da Rocha, Itziar Alkorta, Jone Uria, Juan Ignacio Pérez

(https://culturacientifica.com/2016/06/24/5-anos-catedra-cultura-cientifica-video/)

July 21, 2016

The Lehendakari, at the inauguration of the UPV/EHU Science Park

(http://www.bilbao24horas.com/index.php/euskadi/16949-el-lehendakari-en-la-inauguracion-del-parque-cientifico-de-la-upv-ehu,

http://www.deia.com/2016/07/21/bizkaia/nace-zientzia-parkea-un-espacio-dedicado-a-investigacion-desarrollo-e-innovacion,

http://www.elcorreo.com/bizkaia/201607/22/dentro-parque-cientifico-20160721192255.html)

10

September 30, 2016

A. Shnyrova, one of the five Spanish scientists, awarded by L’Oréal-Unesco

(http://elpais.com/elpais/2016/09/29/ciencia/1475167149_087039.html, http://www.agenciasinc.es/Noticias/Cinco-cientificas-espanolas-premiadas-por-el-programa-L-Oreal-Unesco)

October 6, 2016

F.M. Goñi, appointed President of the Spanish Society of Biochemistry and Molecular Biology

(http://www.ehu.eus/es/content/-/asset_publisher/W6wn/content/n_20161006_felix-goni?redirect=http%3A%2F%2Fwww.ehu.eus%2Fes%2Fhome%3Fp_p_id%3D101_INSTANCE_TaD3%26p_p_lifecycle%3D0%26p_p_state%3Dnormal%26p_p_mode%3Dview%26p_p_c o l _ i d % 3 D c o l u m n - 2 % 2 6 p _ p _ c o l _ p o s % 3 D 1 % 2 6 p _ p _ c o l _count%3D5%26_101_INSTANCE_TaD3_ehuGSA%3DnoIndex)

November 30, 2016

Mannequin Challenge: “Frozen Research” Leioa Instituto Biofisika video presented Mannequin Challenge competition obtained 2nd prize

(http://www.eitb.eus/eu/gaztea/mannequin-challenge/bideoak/osoa/4517781/mannequin-challenge-izoztutako-ikerkuntza-leioatik/)

December 7, 2016

F.M. Goñi doctor honoris causa by the University of Bordeaux

(http://www.sebbm.es/web/en/news/1860-prof-felix-goni-doctor-honoris-causa-by-the-university-of-bordeaux,

http://www.u-bordeaux.com/Research/Honoris-Causa/Our-Honoris-Causa-since-2014)

11

“Euro-BioImaging appointed its Hub and nominates the fi rst generation of Nodes in December 2015”

One of those Nodes is the Advanced Light Microscopy Node Bilbao, Spain. The Bilbao Advanced Light Microscopy Node Candidate is a joint initiative of the imaging platforms of the Instituto Biofi sika and Achucarro Basque Center for Neuroscience, both located in the Science Park of the University of the Basque Country (UPV/EHU). The Node Candidate is focused on quantitative imaging of cellular events such as molecular interactions and biophysical studies such as lipid-mediated protein interactions or lipid-order imaging of model membranes and cells; and on the neurobiology of neuron-glia interactions.

“The atomic structure of the HIV-1 gp41 transmembrane domain and its connection to the immunogenic membrane-proximal external region”

A detailed structural analysis of the human immunodeficiency virus gp41 glycoprotein transmembrane domain reveals new potential targets for MPER vaccines and viral inhibitors.

B. Apellániz, E. Rujas, S. Serrano, K. Morante, K. Tsumoto, J.M. Caaveiro, M.A. Jiménez and J.L. Nieva

J. Biol. Chem. 290, 12999-13015 (2015)

4. IBF milestones

13

The human immunodeficiency virus, or HIV, relies on two glycoproteins, gp41 and gp120, that form a non-covalent complex as the viral envelope. However, structural details of a transmembrane anchor found in gp41 were not known. In this paper high-resolution nuclear magnetic resonance spectroscopy was carried out to analyze this anchor. It was discovered that the anchor contains two helices that are held together by a flexible region. Further biophysical analyses revealed that the N-terminal helix was a scaffold for anti-MPER neutralizing antibodies. The Cterminal helix acted as an immunosuppressor and may contribute to the late stages of the viral fusion process into the host cell. It was concluded, “These data may guide the rational design of MPER vaccines and inhibitors”.

“Synthesis, lipid membrane incorporation, and ion permeability testing of carbon nanotube porins”

R.H. Tunuguntla, A. Escalada, V. Frolov and A. Noy

Nat. Protoc. 11, 2029-2047 (2016)

Carbon Nanotubes (CNTs) of lengths between 10 and 20 nanometers are inserted spontaneously into the plasma cell membrane. They present ionic transport properties similar to those of the cellular ion channels, which together with their non-protein biocompatible origin suggest them as candidates for the control of cell membrane excitability. We describe the protocol for obtaining CNTs for their study in cellular and artificial membranes.

“Glycosylation-dependent IFN-γR partitioning in lipid and actin nanodomains is critical for JAK activation”

C.M. Blouin, Y. Hamon, P. Gonnord, C. Boularan, J. Kagan, C. Viaris de Lesegno, R. Ruez, S. Mailfert, N. Bertaux , D. Loew, C. Wunder, L. Johannes, G. Vogt, FX. Contreras, D. Marguet, J.L. Casanova, C. Galès, H.T. He and C. Lamaze

Cell 166, 920-934 (2016)

The authors identify the molecular mechanism that blocks cell signalling of membrane proteins involved in the immune response.

14

“PTEN recruitment controls synaptic and cognitive function in Alzheimer’s models”

S. Knafo, C. Sanchez-Puelles, E. Palomer, I. Delgado, J.E. Draffin, J. Mingo, T. Wahle, K. Kaleka, L. Mou, I. Pereda-Perez, E. Klosi, E.B. Faber, H.M. Chapman, L. Lozano-Montes, A. Ortega-Molina, L. Ordóñez-Gutiérrez, F. Wandosell, J. Viña, C.G. Dotti, R.A. Hall, R. Pulido, N.Z. Gerges, A.M Chan, M.R. Spaller, M. Serrano, C. Venero and J.A. Esteban

Nat. Neurosci. 19, 443-453 (2016)

15

This new research work, published in Nature Neuroscience reports that in Alzheimer’s disease, synaptic plasticity is altered by a protein originally described as a tumor suppressor: PTEN. In 2010, the research group of Dr. Esteban discovered that PTEN is recruited to synapses during normal (physiological) synaptic plasticity. This new investigation by Drs. Knafo and Esteban now indicates that this mechanism runs uncontrolled during Alzheimer’s disease. One of the pathological agents of the disease, the beta-amyloid, drives PTEN into synapses excessively, unbalancing the mechanisms for synaptic plasticity and impairing memory formation.

Although this is basic research using animal models, these studies contribute to dissect the mechanisms that control our cognitive function, and orient us towards potential therapeutic avenues for mental diseases where these mechanisms are deficient.

“Human Atg8-cardiolipin interactions in mitophagy: Specific properties of LC3B, GABARAPL2 and GABARAP”

Z. Anton, A. Landajuela, J.H. Hervas, L.R. Montes, S. Hernandez-Tiedra, G. Velasco, F.M Goñi and A. Alonso

Autophagy 12, 2386-2403 (2016)

16

The phospholipid cardiolipin (CL) has been proposed to play a role in selective mitochondrial autophagy, or mitophagy. CL externalization to the outer mitochondrial membrane would act as a signal for the human Atg8 orthologs. The latter would mediate both mitochondrial recognition and autophagosome formation, ultimately leading to removal of damaged mitochondria. We have found that LC3B interacts preferentially with CL over other di-anionic lipids, that CL-LC3B binding occurs with positive cooperativity, and that the CL-LC3B interaction relies only partially on electrostatic forces. CL-induced increased membrane fluidity appears also as an important factor helping LC3B to bind CL. http://biofisica.info/anton-alonso-autophagy-12-2386/

“Instituto Biofisika moves to a new building”

The Instituto Biofisika (CSIC, UPV/EHU) moved to the new facilities located in the Science Park of the Campus of Bizkaia. Since late February 2016, research groups and all the scientific instruments were operational in the new building. This new stage coincided with the change of name of this research center, which now is Instituto Biofisika instead of Biophysics Unit.

The new facilities and the new scientific program endorsed by an external committee and supported by the solid base established in the previous stage will allow facing the new challenges of society.

17

The staff of the Instituto Biofisika wanted to say goodbye to their former headquarters with a family photo.

I. Alkorta was awarded with the qualification of EXCELLENT (100,51 points) in the DOCENTIAZ program 5th call (May 2015) (average result of teachers 77 points)

A. Alonso was elected as General Secretary of COSCE (Confederación de Sociedades Científicas de España)

Z. Antón Boehringer Ingelheim Stiftung attendance grant to FEBS-EMBO advanced lecture course “Biomembranes: Molecular Architecture, Dynamics and Function”, Cargèse-Corsica (France) (June 2015)

G. Celaya was awarded with the second position at Roche Prize (XXXIX SEBBM Congress, Salamanca. September 5-8, 2016) “Label-free single-molecule analysis of protein-DNA complexes with nanopores”

F.M. Goñi was declared “Académico Correspondiente de la Real Academia Nacional de Farmacia” (2015)

F.M. Goñi was declared “Académico Numerario de la Real Academia de Medicina del País Vasco” (2016)

F.M. Goñi was invested as Doctor Honoris causa by the Bordeaux University (2016)

S. Knafo was declared Woman of the year in Medicine 2016 by “Women Magazine”. Thanks to the innovative research to develop a drug that makes neurons resistant against Alzheimer’s disease (2016)

S. Knafo was the recipient of a “New Investigator Award” by the Alzheimer´s Association (USA) (2016)

A. Shnyrova was awarded with one of the 5 research grants in the 11th edition of the L’Oréal-UNESCO “For Women in Science” program in Spain (2016)

5. Awards and honours

19

6.1. Directive Team and Administration

Director, Itziar Alkorta (UPV/EHU)

Deputy Director, Álvaro Villarroel (CSIC)

General Manager, Esther Vázquez (CSIC)

Assistant to the Director, María Jesús Peña (UPV/EHU)

Project manager, Ana Julia Vecino (BBF)

Accountant, Ana Franco (CSIC)

Administration, Cristina Clemente (CSIC-INEM) (01/11/2015-31/03/2016)

Administration, Yolanda Ugarte (UPV/EHU) (09/12/2015-08/06/2016)

6.2. Researchers

6.2.1. Scientific staff

Albesa, David, Ikerbasque Research Fellow (until January 31, 2016)

Alkorta, Itziar, Lecturer in Biochemistry (UPV/EHU)

Alonso, Alicia, Professor of Biochemistry (UPV/EHU)

Arrondo, José Luis, Professor of Biochemistry (UPV/EHU)

Bañuelos, Sonia, Permanent Researcher (UPV/EHU)

Basañez, Gorka, Staff Scientist (CSIC)

Contreras, F. Xabier, Ikerbasque Research Fellow

Frolov, Vadim, Ikerbasque Research Professor

Goñi, Félix M., Professor of Biochemistry (UPV/EHU)

Guérin, Diego M., Permanent Researcher (UPV/EHU)

6. Organization

21

Guerin, Marcelo, Ikerbasque Research Professor (until January 31, 2016)

Huarte, Nerea, Associate Lecturer (UPV/EHU)

Knafo, Shira, Ikerbasque Research Professor

Larijani, Banafshe, Ikerbasque Research Professor

Lorizate, Maier, Associate Lecturer (UPV/EHU)

Luecke, Hartmut, Ikerbasque Research Professor (until August 8, 2015)

Martín, César, Associate Lecturer (UPV/EHU)

Moro, Fernando, Permanent Researcher (UPV/EHU)

Muga, Arturo, Professor of Biochemistry (UPV/EHU)

Nieva, José Luis, Professor of Biochemistry (UPV/EHU)

Ostolaza, Helena, Lecturer in Biochemistry (UPV/EHU)

Prado, Adelina, Lecturer in Biochemistry (UPV/EHU)

Requejo, José María, Staff Scientist (CSIC)

Rodríguez Larrea, David, Researcher R y C (UPV/EHU)

Ruiz-Mirazo, Kepa, Permanent Researcher (UPV/EHU)

Shnyrova, Anna, Researcher R y C (UPV/EHU) (Since 01/01/2016)

Terrones, Oihana, Associate Lecturer (UPV/EHU)

Urbaneja, Mª Ángeles, Lecturer in Biochemistry (UPV/EHU)

Viguera, Ana Rosa, Staff Scientist (CSIC)

Vilar, José Manuel, Ikerbasque Research Professor

Villarroel, Álvaro, Staff Scientist (CSIC)

22

6.2.2. Postdoctoral fellows

Aguado, Alejandra

Águila, Sandra (27/06/2015)

Alaimo, Alessandro

Apellaniz, Beatriz

Arana, Lide

Araujo, Aitziber (31/12/2015)

Arkill, Kenton (01/08/2015-30/06/2016)

Arregi, Igor (30/06/2015)

Arroyo, Ana Isabel (12/01/2015-15/07/2015)

Belloso, Kepa

Bernardo, Ganeko (26/10/2016)

Bustillo, Itsasne (03/02/2016)

Busto, Jon (31/12/2015)

Celaya, Garbiñe

Cifuente, Javier (31/01/2016)

De la Arada, Igor

Delgado, Igotz (31/12/2015)

Dos Santos, Ana Catarina (31/12/2015)

Escalada, Artur

Etxebarria, Aitor

Fernández, José Ángel

Dos Santos, Ana Catarina (31/12/2015)

Fernández, José Ángel

Dos Santos, Ana Catarina (31/12/2015)

Fernández, José Ángel

García, Aritz

Gomis, Carolina

Gutiérrez, Marta (28/01/2016)

Hervás, Javier

Landajuela, Ane (31/05/2016)

Landeta, Olatz

Largo, Eneko

Montes, L. Ruth

Morales, Miguel (08/07/2016-18/10/2016)

Ouro, Alberto

Perales, Judit

Sánchez, Lissete (31/12/2016)

Sánchez, Rubén

Sancho, Enea (31/12/2015)

Shnyrova, Anna (31/12/2015)

Postdoctoral fellows abroad

These people are in a postdoctoral-stay awarded by a three-year Basque Government postdoctoral grant

Noemi Jimenez-Rojo

(Howard Riezman Lab. Department of Biochemistry and NCCR Chemical Biology, Sciences II, University of Geneva, Geneva, Switzerland)

24

Marta G. Lete

(Vytas A. Bankaitis Lab. Department of Molecular and Cellular Medicine, Texas A&M Health Science Center, College Station, TX, USA)

Marco Manni

(Bruno Antonny Lab. CNRS, Institut de Pharmacologie Moléculaire et Cellulaire, Université de Nice Sophia-Antipolis, Valbonne, France)

Begoña Ugarte

(Ana García Sáez Lab. University of Tübingen / Max Planck Institute for Intelligent Systems. Interfaculty Institute for Biochemistry, Tübingen, Germany)

6.2.3. PhD Students

Álvarez, Itxaso (Basque Government)

Antón, Zuriñe (UPV/EHU)

Artetxe, Ibai (UPV/EHU)

Benito, Asier (Basque Government)

Bernardo, Ganeko (Basque Government) (31/12/2015)

Bougamra, Ghassen (BBF)

Cabrera, Yovana (UPV/EHU)

Calleja, María (Spanish Ministry)

Carravilla, Pablo (Basque Government)

Comino, Natalia (UPV/EHU-MICINN) (31/01/2016)

Dazzoni, Régine (UPV/EHU-Bordeaux University)

De las Heras, Gloria (Basque Government) (31/12/2015)

25

Dublang, Leire (Basque Government 29/01/2016-11/09/2016) ......

(Spanish Ministry from 12/09/2016)

Etxaniz, Asier (UPV/EHU)

Flores, Hector (Spanish Ministry)

Garaiyurrebaso, Olatz (Basque Government) (31/03/2016)

González, David (BBF)

González, Emilio José (UPV/EHU)

Hervás, Javi (Basque Government) (18/03/2016)

López, Carlos (UPV/EHU) (31/12/2015)

López, Ibai (BBF) (31/12/2015)

López, Nerea (UPV/EHU) (31/12/2015)

Metola, Ane (Basque Government)

Morana, Ornella (UPV/EHU-Spanish Ministry)

Murillo, Sara (UPV/EHU) (31/03/2016)

Nieto, Jon Ander (Basque Government)

Nuñez, Eider (Basque Government)

Rodrigo, Ane (Spanish Ministry) (31/12/2015)

Rodríguez, Eva (BBF) (28/02/2015)

Rujas, Edurne (Basque Government)

Sánchez, Rubén (Basque Government) (31/12/2015)

Tersa, Montserrat (BBF) (31/01/2016)

Velasco, Ariana (Spanish Ministry)

26

6.2.4. Undergraduate Students

Aguirre, Laura

Arregi, Ane

Asua, Diego

Barberán, Ainhoa

Bayón, Laura

Buela, Ildefonso

Couto, Maite

Escobero, Asier

Fernández, Jon Ander

Franco, Aitor

Galicia, Unai

García, Mikel

Gutiérrez, Andrea

Gutiérrez, Bingen

Hurtado, Mikel

Insausti, Sara

Iriondo, Marina

Jebari, Shifa

Larrea, Asier

Martín, Itziar

Muguruza, Arantza

Iriondo, Marina

Jebari, Shifa

Larrea, Asier

Martín, Itziar

Muguruza, Arantza

Ortigosa, Lei

Ortiz de Salazar, Iñigo

Peñalver, Beatriz

Roa, Aritz

Rodríguez , Goiuri

Romero, Pablo

Ruiz, Miren Itziar

Sarasola, Laura Isabel

Siddiqi, Haziq

Terroba, Paula

Torralba, Johana

Ulloa, María de Covadonga

Vicente, Beatriz

6.3. Technicians

Alonso, Rocío (BBF)

Alonso, Marián (BBF)

Arrasate, Pedro (Spanish Ministry-BBF) (24/08/2015)

Bilbao, Eneritz (BBF)

Ciceri, Dalila (BBF)

Durana, Aritz (BBF)

28

Escribano, Raúl (BBF)

García, Miguel (BBF)

López, Sonia (BBF)

Lorenzo, Unai (BBF)

Malo, Covadonga (Spanish Ministry - BBF)

Marcos, Araceli (BBF)

Ormaetxea, Julene (BBF)

Orozko, Natalia (BBF)

Sot, Jesús, (UPV/EHU) (Spanish Ministry - BBF)

6.4. Reception

Cerezo, Begoña (UPV/EHU)

6.5. Cleaning Staff

López de Ahumada, Elena (Company Uni2; Manager: Orozco, José Luis).

6.6. BBF

Cea, Iñigo (BBF)

Darvas, Raquel (BBF)

García-Etxabe, Agurtzane (BBF) (29/02/2016)

Martín, Manuel (BBF) (29/02/2016)

29

7.1. PhD Theses

“Calmodulin regulation of Kv7.2 potassium channels” (International thesis)

Araitz Alberdi González

Supervisor: Álvaro Villarroel Muñoz

30 January 2015

“ClpB dynamics and functional versatility”

Alejandra Aguado Martínez

Supervisors: Arturo Muga Villate and Fernando Moro Pérez

25 March 2015

“Development of soft and rigid membrane nanotemplates for the mechanistic analysis of dynamin 1 action on curved surfaces”

Eva Rodríguez Hortelano

Supervisors: Vadim Frolov and Anna Shnyrova

26 March 2015

“Membrane activities of dynamin-related protein 1 (DRP1) and BCL2-related ovarian killer (BOK)” (International thesis)

Itsasne Bustillo Zabalbeitia

Supervisors: Gorka Basañez Asua and Oihana Terrones Urio

27 March 2015

7. Scientific highlights

31

“The PtdIns(3,4,5)P3 and PtdSer dependent mechanism of PDK1 regulation in cancer cells” (International thesis)

Gloria de las Heras Martínez

Supervisors: José María Requejo Isidro and Banafshe Larijani

17 November 2015

“Conformational transitions modulate glycosyltransferase function at the membrane surface” (International thesis)

Ane Rodrigo Unzueta

Supervisor: Marcelo E. Guerin

3 December 2015

“Morphogenesis, uncoating and VP4 function in dicistroviruses” (International thesis)

Rubén Sánchez Eugenia

Supervisor: Diego M.E. Guérin Aguilar

11 December 2015

“Structural characterization of helices A and B of Kv7.2 channel bound to calmodulin. The calcium effect” (International thesis)

Ganeko Bernardo Seisdedos

Supervisors: Álvaro Villarroel Muñoz and Óscar Millet Aguilar-Galindo

15 December 2015

32

“Autophagy-related proteins: in vitro studies of protein-lipid interactions modulating autophagosome elongation” (International thesis)

Javier Hervás Hidalgo

Supervisors: Alicia Alonso Izquierdo and Lidia Ruth Montes Burgos

18 March 2016

“Soils under long-term aided phystostabilization are a reservoir for transmissible antibiotic resistance plasmids” (International thesis)

Olatz Garaiyurrebaso Rodríguez

Supervisors: Itziar Alkorta Calvo and Elisabeth Grohmann

28 June 2016

“Mechanisms of MPER helix binding at membrane interfaces and implications for the broad neutralization of HIV by antibodies” (International thesis)

Edurne Rujas Díaz

Supervisors: José Luis Nieva Escandón and José Manuel Martínez Caaveiro

16 December 2016

7.2. Patents

INVENTORS: J.F. Rodríguez Aguirre and D.M. Guérin AguilarTITLE: “VLPs, Methods for their obtention and application thereof”APPLICANT: UPV/EHU and Fundación Biofísica BizkaiaPCT APPLICATION Number: 15702968.7-1402/3089755PRIORITY DATE: July 9, 2015PRIORITY COUNTRY: Europe

33

7.3. Publications

“Geometry of membrane fission”. V.A. Frolov, A. Escalada, S.A. Akimov and A.V. Shnyrova. Chem. Phys. Lipids. 185, 129-140 (2015)

“A combinatorial approach to the design of vaccines”. L. Martínez, M. Milani, M. Legarreta, P. Medvedev, I. Malaina and I.M. de la Fuente. J. Math. Biol. 70, 1327-1358 (2015)

“Functional characterization and classification of frequent low-density lipoprotein receptor variants”. A. Etxebarria, A. Benito-Vicente, L. Palacios, M. Stef, A. Cenarro, F. Civeira, H. Ostolaza and C. Martin. Hum. Mutat. 36, 129-141 (2015)

“Secondary structure reshuffling modulates glycosyltransferase function at the membrane”. D. Giganti, D. Albesa-Jové, S. Urresti, A. Rodrigo-Unzueta, M.A. Martínez, N. Comino, N. Barilone, M. Bellinzoni, A. Chenal, M.E. Guerin and P.M. Alzari. Nat. Chem. Biol. 11, 16-18 (2015)

“Interaction of Clostridium perfringens epsilon-toxin with biological and model membranes: A putative protein receptor in cells”. M.M. Manni, J. Sot and F.M. Goñi. Biochim. Biophys. Acta 1848, 797–804 (2015)

“Activity-associated effect of LDL receptor missense variants located in the cysteine-rich repeats”. A. Etxebarria, A. Benito-Vicente, M. Stef, H. Ostolaza, L. Palacios and C. Martin. Atherosclerosis 238, 304-312 (2015)

“Emergent chemical behavior in variable-volume protocells”. B. Shirt-Ediss, R.V. Solé and K. Ruiz-Mirazo. Life 5, 1-31 (2015)

“Solvation and hydration of the ceramide headgroup in a non-polar solution”. R.J. Gillams, J.V. Busto, S. Busch, F.M. Goñi, C.D. Lorenz and S.E. McLain. J. Phys. Chem. B 119, 128−139 (2015)

“Characterization of the insertase BamA in three different membrane mimetics by solution NMR spectroscopy”. L. Morgado, K. Zeth, B.M. Burmann, T. Maier and S. Hiller. J. Biomol. NMR. 61, 333-345 (2015)

34

“The dipeptidyl peptidase IV inhibitors vildagliptin and K-579 inhibit a phospholipase C: a case of promiscuous scaffolds in proteins” S. Chakraborty, A. Rendón-Ramírez, B. Ásgeirsson, M. Dutta, A.S. Ghosh, M. Oda, R. Venkatramani, B.J. Rao, A.M. Dandekar and F.M. Goñi. Version 3. F1000Res. 2013 Dec 27 [revised 2015 Jan 29];2:286. doi: 10.12688/f1000research.2-286.v3. eCollection 2013 (2015)

“Cognitive enhancement. Pharmacologic, environmental and genetic factors”. S. Knafo and C. Venero (eds.). Academic Press, London, pp. 392. ISBN 978-0-12-417042-1 (L) (2015)

“Fusion-competent state induced by a C-terminal HIV-1 fusion peptide in cholesterol-rich membranes”. B. Apellániz and J.L. Nieva. Biochim. Biophys. Acta 1848, 1014–1022 (2015)

“Low pH modulates the macroorganization and thermal stability of PSII supercomplexes in grana membranes”. S. Stoichev, S.B. Krumova, T. Andreeva, J.V. Busto, S. Todinova, K. Balashev, M. Busheva, F.M. Goñi, and S.G. Taneva. Biophys. J. 108, 844–853 (2015)

“Histones cause aggregation and fusion of lipid vesicles containing phosphatidylinositol-4-phosphate”. M.G. Lete, J. Sot, D. Gil, M. Valle, M. Medina, F.M. Goñi, and A. Alonso. Biophys. J. 108, 863-871 (2015). Selected paper of the month by the SBE February 2015 and recommended by Faculty of 1000 (https://f1000.com/prime/725357385)

“Fluorescent polyene ceramide analogues as membrane probes”. I. Nieves, I. Artetxe, J.L. Abad, A. Alonso, J.V. Busto, L. Fajarí, L.R. Montes, J. Sot, A. Delgado and F.M. Goñi. Langmuir 31, 2484-2492 (2015)

“Atomic force microscopy characterization of palmitoylceramide and cholesterol effects on phospholipid bilayers: a topographic and nanomechanical study”. A.B. García-Arribas, J.V. Busto, A. Alonso and F.M. Goñi. Langmuir 31, 3135-3145 (2015)

“Two-photon L aurdan studies of the ternary lipid mixture D O P C : S M : c h o l e st e ro l re v e a l a s i ng l e l i q u i d p h a s e a t sphingomyelin:cholesterol ratios lower than 1”. P. Carravilla, J.L. Nieva, F.M. Goñi, J. Requejo-Isidro and N. Huarte. Langmuir 31, 2808-2817 (2015)

PU

BLI

CA

TIO

NS

35

“Triatoma virus recombinant VP4 protein induces membrane permeability through dynamic pores”. R. Sánchez-Eugenia, J. Goikolea, D. Gil-Cartón, L. Sánchez-Magraner and D.M. Guérin. J. Virol. 89, 4645-4654 (2015)

“Seroprevalence of Triatoma virus (Dicistroviridae: Cripaviridae) antibodies in Chagas disease patients”. J.F. Querido, M.G. Echeverría, G.A. Marti, R.M. Costa, M.L. Susevich, J.E. Rabinovich, A. Copa, N.A. Montaño, L. Garcia, M. Cordova, F. Torrico, R. Sánchez-Eugenia, L. Sánchez-Magraner, X. Muñiz-Trabudua, I. López-Marijuan, G.S. Rozas-Dennis, P. Diosque, A.M. de Castro, C. Robello, J.S. Rodríguez, J. Altcheh, P.M. Salazar-Schettino, M.I. Bucio, B. Espinoza, D.M. Guérin and M.S. Silva. Parasit. Vectors 8:29. doi: 10.1186/s13071-015-0632-9 (2015)

“The importance of an integrated analysis of clinical, molecular, and functional data for the genetic diagnosis of familial hypercholesterolemia”. A. Benito-Vicente, A.C. Alves, A. Etxebarria, A.M. Medeiros, C. Martin and M. Bourbon. Genet. Med. 17, 980-988 (2015)

“Functional proteomic biomarkers in cancer”. B. Larijani, M. Perani, K. Alburai’si and P.J. Parker. Ann. N.Y. Acad. Sci. doi: 10.1111/nyas.12749 (2015)

“C8-glycosphingolipids preferentially insert into tumor cell membranes and promote chemotherapeutic drug uptake”. L.R. Cordeiro Pedrosa, W.A. van Cappellen, B. Steurer, D. Ciceri, T.L. Ten Hagen, A.M. Eggermont, M. Verheij, F.M. Goñi, G.A. Koning and F.X. Contreras. Biochim. Biophys. Acta 1850, 1656-1670 (2015)

“End-product diacylglycerol enhances the activity of PI-PLC through changes in membrane domain structure”. H. Ahyayauch, J. Sot, M.I. Collado, N. Huarte, J. Requejo-Isidro, A. Alonso and F.M. Goñi. Biophys. J. 108, 1672-1682 (2015)

“Ceramide increases free volume voids in DPPC membranes”. E. Axpe, A.B. García-Arribas, J.I. Mujika, D. Mérida, A. Alonso, X. Lopez, J.A. García, J.M. Ugalde, F.M. Goñi and F. Plazaola. RSC Adv. 5, 44282-44290 (2015)

36

“A native ternary complex trapped in crystal reveals the catalytic mechanism of a retaining glycosyltransferase”. D. Albesa-Jové, F. Mendoza, A. Rodrigo-Unzueta, F. Gomollón-Bel, J.O. Cifuente, S. Urresti, N. Comino, H. Gómez, J. Romero-García, J.M. Lluch, E. Sancho-Vaello, X. Biarnés, A. Planas, P. Merino, L. Masgrau and M.E. Guerin Angew Chem. Int. Ed. Engl. 54, 9898-9902 (2015)

“Minimalist model systems reveal similarities and differences between membrane interaction modes of MCL1 and BAK”. O. Landeta, A. Landajuela, A. Garcia-Saez and G. Basañez. J. Biol. Chem. 290, 17004-17019 (2015)

“Leukemia-associated mutations in nucleophosmin alter recognition by CRM1: Molecular basis of aberrant transport”. I. Arregi, J. Falces, A. Olazabal-Herrero, M. Alonso-Mariño, S.G. Taneva, J.A. Rodríguez, M.A. Urbaneja and S. Bañuelos. PLoS ONE 10(6): e0130610. doi:10.1371/journal.pone.0130610 (2015)

“A hemi-fission intermediate links two mechanistically distinct stages of membrane fission”. J.P. Mattila, A.V. Shnyrova, A.C. Sundborger, E.R. Hortelano, M. Fuhrmans, S. Neumann, M. Müller, J.E. Hinshaw, S.L. Schmid and V.A. Frolov. Nature 524, 109-113 (2015). Selected paper of the month by the SBE August 2015

“Epilepsy-causing mutations in Kv7.2 C-terminus affect binding and functional modulation by calmodulin”. P. Ambrosinoa, A. Alaimo, S. Bartollino, L. Manocchio, M. De Maria, I. Mosca, C. Gomis-Pérez, A. Alberdi, G. Scambia, G. Lesca, A. Villarroel, M. Taglialatela and M.V. Soldovieri. Biochim. Biophys. Acta 1852, 1856–1866 (2015)

“The systems perspective at the crossroads between chemistry and biology”. A. de la Escosura, C. Briones and K. Ruiz-Mirazo. J. Theor. Biol. 381, 11-22 (2015)

“Lipids that determine detergent resistance of MDCK cell membrane fractions”. M.M. Manni, A. Cano, C. Alonso and F.M. Goñi. Chem. Phys. Lipids 191, 68–74 (2015)

PU

BLI

CA

TIO

NS

37

“Lipidic nanovesicles stabilize suspensions of metal oxide nanoparticles”. N. Jiménez-Rojo, M.G. Lete, E. Rojas, D. Gil, M. Valle, A. Alonso, S.E. Moya and F.M. Goñi. Chem. Phys. Lipids 191, 84-90 (2015)

“Adenylate cyclase toxin promotes bacterial internalisation into non phagocytic cells”. C. Martín, A. Etxaniz, K.B. Uribe, A. Etxebarria, D. González-Bullón, J. Arlucea, F.M. Goñi, J. Aréchaga and H. Ostolaza. Scientific Reports 5:13774. DOI: 10.1038/srep13774 1 (2015)

“Unconventional calmodulin-anchoring site within the AB module of Kv7.2 channels”. C. Gomis-Pérez, A. Alaimo, J. Fernandez-Orth, A. Alberdi, P. Aivar-Mateo, G. Bernardo-Seisdedos, C. Malo, P. Areso, A. Felipe and A. Villarroel. J. Cell Sci. 128, 3155-3163 (2015). Selected paper of the month by the SBE August 2015

“A commensal strain of Staphylococcus epidermidis overexpresses membrane proteins associated with pathogenesis when grown in biofilms” S. Águila-Arcos, S. Ding, K. Aloria, J.M.Arizmendi, I.M. Fearnley, J.E. Walker, F.M. Goñi and I. Alkorta. J. Membr. Biol. 248, 431-442 (2015)

“Type I phosphatidylinositol 4-phosphate 5-kinase homo- and heterodimerization determines its membrane localization and activity”. R.A. Lacalle, J.C. de Karam, L. Martínez-Muñoz, I. Artetxe, R.M. Peregil, J. Sot, A.M. Rojas, F.M. Goñi, M. Mellado and S. Mañes. FASEB J. 29, 2371-2385 (2015)

“Solid lipid nanoparticles for delivery of Calendula officinalis extract”. L. Arana, C. Salado, S. Vega, O. Aizpurua-Olaizola, I. Arada, T. Suarez, A. Usobiaga, J.L. Arrondo, A. Alonso, F.M. Goñi and I. Alkorta. Colloids Surf. B Biointerfaces135, 18-26 (2015)

“New antimicrobial contact catalyst killing antibiotic resistant clinical and waterborne pathogens”. A. Guridi, A.K. Diederich, S. Aguila-Arcos, M. Garcia-Moreno, R. Blasi, M. Broszat, W. Schmieder, E. Clauss-Lendzian, T. Sakinc-Gueler, R. Andrade, I. Alkorta, C. Meyer, U. Landau and E. Grohmann. Mat. Sci. Eng. C Mater Biol. Appl. 50, 1-11 (2015)

38

“Triatoma virus structural polyprotein expression, processing and assembly into virus-like particles”. R. Sánchez-Eugenia, F. Méndez, J.F. Querido, M.S. Silva, D.M. Guérin and J.F. Rodríguez. J. Gen. Virol. 96, 64-73(2015)

“Uncoupling PIP2-calmodulin regulation of Kv7.2 channels by an assembly destabilizing epileptogenic mutation”. A. Alberdi, C. Gomis-Perez, G. Bernardo-Seisdedos, A. Alaimo, C. Malo, J. Aldaregia, C. Lopez-Robles, P. Areso, E. Butz, C. Wahl-Schott and A. Villarroel. J. Cell Sci. 128, 4014-4023 (2015)

“Characterization of the first PCSK9 gain of function homozygote”. A.C. Alves, A. Etxebarria, A.M. Medeiros, A. Benito-Vicente, A. Thedrez, M. Passard, M. Croyal, C. Martin, G. Lambert and M. Bourbon. J. Am. Coll. Cardiol. 66, 2152-2154 (2015)

“The redox state regulates the conformation of Rv2466c to activate the antitubercular prodrug TP053”. D. Albesa-Jové, N. Comino, M. Tersa, E. Mohorko, S. Urresti, E. Dainese, L.R. Chiarelli, M.R. Pasca, R. Manganelli, V. Makarov, G. Riccardi, D.I. Svergun, R. Glockshuber and M.E. Guerin. J. Biol. Chem. 290, 31077-31089 (2015). Selected paper of the month by the SBE December 2015

“Structural analysis of APOB variants, p.(Arg3527Gln), p.(Arg1164Thr) and p.(Gln4494del), causing Familial Hypercholesterolaemia provides novel insights into variant pathogenicity”. J.A. Fernández-Higuero, A. Etxebarria, A. Benito-Vicente, A.C. Alves, J.L. Arrondo, H. Ostolaza, M. Bourbon and C. Martin. Scientific Reports 5:18184. doi: 10.1038/srep18184 (2015)

“Sedimentation equilibrium analysis of ClpB self-association in diluted and crowded solutions”. C. Alfonso, U. del Castillo, I. Martín, A. Muga and G. Rivas. Methods Enzymol. 562, 135-60 (2015)

“Chaperone-assisted protein aggregate reactivation: Different solutions for the same problem”. A. Aguado, J.A. Fernández-Higuero, F. Moro and A. Muga. Arch. Biochem. Biophys. 580, 121-134 (2015)

PU

BLI

CA

TIO

NS

39

“Modulation of the chaperone DnaK allosterism by the nucleotide exchange factor GrpE”. R. Melero, F. Moro, M.A. Pérez-Calvo, J. Perales-Calvo, L. Quintana-Gallardo, O. Llorca, A. Muga and J.M. Valpuesta. J. Biol. Chem. 290, 10083-10092 (2015)

“ClpB dynamics is driven by its ATPase cycle and regulated by the DnaK system and substrate proteins”. A. Aguado, J.A. Fernández-Higuero, Y. Cabrera, F. Moro and A. Muga. Biochem. J. 466, 561-570 (2015)

“Structural and thermodynamic basis of epitope binding by neutralizing and nonneutralizing forms of the anti-HIV-1 antibody 4E10”. E. Rujas, N. Gulzar, K. Morante, K. Tsumoto, J.K. Scott, J.L. Nieva and J.M. Caaveiro. J. Virol. 89, 11975-11989 (2015)

“The use of liposomes to shape epitope structure and modulate immunogenic responses of peptide vaccines against HIV MPER”. B. Apellániz and J.L. Nieva. Adv. Protein. Chem. Struct. Biol. 99, 15-54 (2015)

“The atomic structure of the HIV-1 gp41 transmembrane domain and its connection to the immunogenic membrane-proximal external region”. B. Apellániz, E. Rujas, S. Serrano, K. Morante, K. Tsumoto, J.M. Caaveiro, M.A. Jiménez and J.L. Nieva. J. Biol. Chem. 290, 12999-13015 (2015). Paper selected as “Article of the Week” by the Editorial Board of J. Biol. Chem

“Fusion-competent state induced by a C-terminal HIV-1 fusion peptide in cholesterol-rich membranes”. B. Apellániz and J.L. Nieva. Biochim. Biophys. Acta. 1848, 1014-1022 (2015)

“Acidic pH and divalent cation sensing by PhoQ are dispensable for systemic salmonellae virulence”. K.G. Hicks, S.P. Delbecq, E. Sancho-Vaello, M.P. Blanc, K.K. Dove, L.R. Prost, M.E. Daley, K. Zeth, R.E. Klevit and S.I. Miller. Elife 4:e06792. doi: 10.7554/eLife.06792 (2015)

“Antimicrobial peptides: has their time arrived?”. E. Sancho-Vaello and K. Zeth. Future Microbiol. 10, 1103-1106 (2015)

“Early gene expression in Pseudomonas fluorescens exposed to a polymetallic solution”. M.T. Gómez-Sagasti, J.M. Becerril, L. Epelde, I. Alkorta and C. Garbisu. Cell Biol.Toxicol. 31, 39-81 (2015)

40

“Thermally-induced aggregation and fusion of protein-free lipid vesicles”. M. Ibarguren, P.H.H. Bomans, K. Ruiz-Mirazo, P.M. Frederik, A. Alonso and F.M. Goñi. Colloids Surf. B Biointerfaces 136, 545-552 (2015)

“Sec14-nodulin proteins and the patterning of phosphoinositide landmarks for developmental control of membrane morphogenesis”. R. Ghosh, M.K.F. De Campos, J. Huang, S.K. Huh, A. Orlowski, Y. Yang, A. Tripathi, A. Nile, H.C. Lee, M. Dynowski, H. Schäfer, T. Róg, M.G. Lete, H. Ahyayauch, A. Alonso, I. Vattulainen, T.I. Igumenova, G. Schaaf and V.A. Bankaitis. Mol. Biol. Cell 26, 1764-1781 (2015). Recommended by Faculty of 1000 (https://f1000.com/prime/725375463)

“Endomembrane PtdIns(3,4,5)P3 activates the PI3K-Akt pathway”. N. Jethwa, G.H. Chung, M.G. Lete, A. Alonso, R.D. Byrne, V. Calleja and B. Larijani. J. Cell Science 128, 3456-3465 (2015)

“Standard fluorescent proteins as dual-modality probes for correlative experiments in an integrated light and electron microscope”. E. Brama, C.J. Peddie, M.L. Jones, M.C. Domart, X. Snetkov, M. Way, B. Larijani and L.M. Collinson. J. Chem. Biol. 8, 179-188 (2015)

“Viroporins: Structures and functions beyond cell membrane permeabilization”. J.L. Nieva and L. Carrasco. Viruses 7, 5169-5171 (2015)

“Functional characterization of Val60, a key residue involved in the membrane-oligomerization of fragaceatoxin C, an actinoporin from Actinia fragacea”. K. Morante, J.M.M. Caaveiro, A.R. Viguera, K. Tsumoto and J.M. González-Mañas. FEBS Lett. 589, 1840-1846 (2015)

“Molecular mechanisms of drug-induced cognitive enhancement”. S. Knafo and J.A. Esteban. Cognitive Enhancement: Pharmacologic, Environmental and Genetic Factors. pp 43-59 (2015) (Book Chapter)

“Alzheimer’s disease and mechanism-based attempts to enhance cognition”. J.E. Draffin, S. Knafo and M.T. Heneka. Cognitive Enhancement: Pharmacologic, Environmental and Genetic Factors. pp. 193-231 (2015) (Book Chapter)

PU

BLI

CA

TIO

NS

41

“What is cognitive enhancement?”. V. Dubljevi, C. Venero and S. Knafo. Cognitive Enhancement: Pharmacologic, Environmental and Genetic Factors. pp 1-9 (2015) (Book Chapter)

“An unconventional calmodulin-anchoring site within the AB module of kv7.2 channels”. C. Gomis-Perez, A. Alaimo, J. Fernandez-Orth, A. Alberdi, P. Aivar Mateo, G. Bernardo-Seisdedos, C. Malo, P. Areso, A. Felipe and A. Villarroel. J. Cell Sci. 128, 3155-3163 (2015)

“Calorimetric features of IgM gammopathies. Implication for patient’s diagnosis and monitoring”. S. Krumova, S. Todinova, A. Danailova, V. Petkova, K. Dimitrova, L. Gartcheva and S.G. Taneva. Thermochim. Acta 615, 23-29 (2015)

“Challenging the state of the art in protein structure prediction: Highlights of experimental target structures for the 10th critical assessment of techniques for protein structure prediction experiment CASP10”. A. Kryshtafovych, J. Moult, P. Bales, J.F. Bazan, M. Biasini, A. Burgin, C. Chen, F.V. Cochran, T.K. Craig, R. Das, D. Fass, C. Garcia-Doval, O. Herzberg, D. Lorimer, H. Luecke, X.L. Ma, D.C. Nelson, M.J. van Raaij, F. Rohwer, A. Segall, V. Seguritan, K. Zeth and T. Schwede. Proteins 83, 1198-1198 (2015)

“A novel KCNQ3 mutation in familial epilepsy with focal seizures and intellectual disability”. F. Miceli, P. Striano, M.V. Soldovieri, A. Fontana, R. Nardello, A. Robbiano, G. Bellini, M. Elia, F. Zara, M. Taglialatela and S. Mangano. Epilepsia 56, E15-E20 (2015)

“Structure determination of the BAM complex accessory lipoproteins BamB-E”. K. Zeth. Methods Mol. Biol. 1329, 189-202 (2015)

“Mechanistic contributions of biological cofactors in islet amyloid polypeptide amyloidogenesis”. P.T. Nguyen, N. Andraka, C.A. De Carufel and S. Bourgault. J. Diabetes Res. 515307 doi: 10.1155/2015/515307 (2015)

“Sub-nanoscale free volume and local elastic modulus of chitosan-carbon nanotube biomimetic nanocomposite scaffold-materials”. E. Axpe, L. Bugnicourt, D. Merida, M. Goiriena-Goikoetxea, I. Unzueta, R. Sanchez-Eugenia, J.A. Garcia, F. Plazaola and S. Contera. J. Mater. Chem. B 3, 3169-3176 (2015)

442

“The use of targeted exome sequencing in genetic diagnosis of young patients with severe hypercholesterolemia”. L. Jiang, W.F.Wu, L.Y. Sun, P.P. Chen, W. Wang, A. Benito-Vicente, F. Zhang, X.D. Pan, W. Cui, S.W. Yang, Y.J. Zhou, C. Martin and L.Y. Wang. Scientific Reports 6, 36823 doi. 10.1038/srep36823 (2016)

“Ion channel activity of the CSFV p7 viroporin in surrogates of the ER lipid bilayer”. E. Largo, C. Verdiá-Báguena, V.M. Aguilella, J.L. Nieva and A. Alcaraz. Biochim. Biophys. Acta1858, 30-37 (2016)

“Structural changes induced by acidic pH in human apolipoprotein B-100”. J.A. Fernández-Higuero, A. Benito-Vicente, A. Etxebarria, J.C. Milicua, H. Ostolaza, J.L. Arrondo and C. Martín. Scientific Reports 6, 36324 doi: 10.1038/srep36324 (2016)

“PCSK9 and lipoprotein (a) levels are two predictors of coronary artery calcification in asymptomatic patients with familial hypercholesterolemia”. R. Alonso, P. Mata, O. Muñiz, F. Fuentes-Jimenez, J.L. Díaz, D. Zambón, M. Tomás, C. Martin, T. Moyon, M. Croyal, A. Thedrez and G. Lambert. Atherosclerosis 254, 249-253 (2016)

“Synthesis, lipid membrane incorporation, and ion permeability testing of carbon nanotube porins”. R.H. Tunuguntla, A. Escalada, V. Frolov and A. Noy. Nat. Protoc. 11, 2029-2047 (2016)

“Cholesterol interactions with ceramide and sphingomyelin”. A.B. García-Arribas, A. Alonso and F.M. Goñi. Chem. Phys. Lipids. 199, 26-34 (2016)

“Glycosylation-dependent IFN-R partitioning in lipid and actin nanodomains is critical for JAK activation”. C.M. Blouin, Y. Hamon, P. Gonnord, C. Boularan, J. Kagan, C. Viaris de Lesegno, R. Ruez, S. Mailfert, N. Bertaux , D. Loew, C. Wunder, L. Johannes, G. Vogt, F.X. Contreras, D. Marguet, J.L. Casanova, C. Galès, H.T. He and C. Lamaze. Cell 166, 920-934 (2016)

“Cholesterol-ceramide interactions in phospholipid and sphingolipid bilayers as observed by positron annihilation lifetime spectroscopy and molecular dynamics simulations”. A.B. García Arribas, R. Axpe, J.I. Mujika, D. Mérida, J.V. Busto, J. Sot, A. Alonso, X. Lopez, J.A. García, J.M. Ugalde, F. Plazaola and F.M. Goñi. Langmuir 32, 5434-5444 (2016)

PU

BLI

CA

TIO

NS

43

“A cellular reporter to evaluate CRM1 nuclear export activity: functional analysis of the cancer-related mutant E571K”. I. García-Santisteban, I. Arregi, M. Alonso-Mariño, M.A. Urbaneja, J.J. Garcia-Vallejo, S. Bañuelos and J.A. Rodríguez. Cell Mol. Life. Sci. 73, 4685-4699 (2016)

“Reflections on the origin of life. More than an ‘evolutionary’ problem”. K. Ruiz-Mirazo and A. Moreno. Mètode SSJ. 6, 151-159 (2016)

“Fatty acids double role in the prebiotic formation of a hydrophobic dipeptide”. S. Murillo-Sánchez, D. Beaufils, J. M. González Mañas, R. Pascal and K. Ruiz-Mirazo. Chem. Sci. 7, 3406-3413 (2016)

“A quantitative characterization of nucleoplasmin/histone complexes reveals chaperone versatility”. N. Fernandez-Rivero, A. Franco, A, Velazquez-Campoy, E. Alonso, A. Muga and A. Prado. Scientific Reports 6, 32114 doi.10.1038/srep 32114 (2016). Selected paper of the month by the SBE August 2016

“Crowding modulates the conformation, affinity, and activity of the components of the bacterial disaggregase machinery”. G. Celaya, J. A. Fernandez-Higuero, I. Martin, G. Rivas, F. Moro and A. Muga. J. Mol. Biol. 428, 2474-2487 (2016)

“Ubiquitin-specific protease 36 (USP36) controls neuronal precursor cell-expressed developmentally down-regulated 4-2 (Nedd4-2) actions over the neurotrophin receptor TrkA and potassium voltage-gated channels 7.2/3 (Kv7.2/3)”. B. Anta, C. Martín-Rodríguez, C. Gomis-Perez, L. Calvo, S. López-Benito, A.A. Calderón-García, C. Vicente-García, A. Villarroel and J.C. Arévalo. J. Biol. Chem. 291, 19132-19145 (2016)

“Human Atg8-cardiolipin interactions in mitophagy: Specific properties of LC3B, GABARAPL2 and GABARAP”. Z. Anton, A. Landajuela, J.H. Hervas, L.R. Montes, S. Hernandez-Tiedra, G. Velasco, F.M Goñi and A. Alonso. Autophagy 12, 2386-2403 (2016). Selected paper of the month by the SBE December 2016

444

“Ceramide-induced lamellar gel phases in fluid cell lipid extracts”. A.B. Garcia-Arribas, H. Ahyayauch, J. Sot, P.L. Lopez-Gonzalez, A. Alonso and F.M. Goñi. Langmuir 32, 9053-9063 (2016). Selected paper of the month by the SBE September 2016

“Lipid geometry and bilayer curvature modulate LC3/GABARAP-mediated model autophagosomal elongation”. A. Landajuela, J.H. Hervas, Z. Anton, L.R. Montes, D. Gil, M. Valle, J.F. Rodriguez, F.M. Goñi and A. Alonso. Biophys. J. 110, 411–422 (2016)

“A small molecule inhibitor of PDK1/PLC 1 interaction blocks breast and melanoma cancer cell invasion”. C. Raimondi, V. Calleja, R. Ferro, A. Fantin, A.M. Riley, B.V. Potter, C.H. Brenan, T. Maffucci, B. Larijani and M. Falasca. Scientific Reports 6, 26142 doi.10.1038/srep26142 (2016)

“The use of two-photon FRET-FLIM to study protein interactions during nuclear envelope fusion in vivo and in vitro”. R.D. Byrne, B. Larijani and D.L. Poccia. Methods Mol. Biol. 1411, 123-132 (2016)

“Correction: HER2 phosphorylation is maintained by a PKB negative feedback loop in response to anti-HER2 herceptin in breast cancer”. M. Gijsen, P. King, T. Perera, P.J. Parker, A.L. Harris, B. Larijani and A. Kong. PLoS Biol. 7, e1002414. doi: 10.1371/journal.pbio.1002414 (2016)

“The p.Leu167del mutation in APOE gene causes autosomal dominant hypercholesterolemia by down-regulation of LDL receptor expression in hepatocytes”. A. Cenarro, A. Etxebarria, I. De Castro-Oros, M. Stef, A.M. Bea, L. Palacios, R. Mateo-Gallego, A. Benito-Vicente, H. Ostolaza, T. Tejedor, C. Martin and F. Civeira. J. Clin. Endocrinol. Metab. 101, 2113-2121 (2016)

“X-ray structure of Triatoma virus empty capsid: insights into the mechanism of uncoating and RNA release in dicistroviruses”. R. Sanchez Eugenia, A. Durana, I. Lopez-Marijuan, G.A. Marti and D.M. Guérin. J. Gen. Virol. 97, 2769-2779 (2016)

PU

BLI

CA

TIO

NS

45

“Structural basis for broad neutralization of HIV-1 through the molecular recognition of 10E8 helical epitope at the membrane interface”. E. Rujas, J.M. Caaveiro, A. Partida-Hanon, N. Gulzar, K. Morante, B. Apellániz, M. García-Porras, M. Bruix, K. Tsumoto, J.K. Scott, M.A. Jiménez and J.L. Nieva.Scientific Reports 6, 38177 doi.10.1038/srep38177 (2016). Selected paper of the month by the SBE December 2016

“A crowdsourcing approach to developing and assessing prediction algorithms for AML prognosis”. D.P. Noren, B.L. Long, R. Norel, K. Rrhissorrarrakrai, K. Hess, C.W. Hu, A.J. Bisberg, A. Schulz, E. Engquist, L. Liu, X. Lin, G.M. Chen, H. Xie, G.A.M. Hunter, P.C. Boutros, O. Stepanov, DREAM 9 AML-OPC Consortium, T. Norman, S.H. Friend, G. Stolovitzky, S. Kornblau and A.A. Qutub. PloS Comput. Biol. 12:e1004890. doi: 10.1371/journal.pcbi.1004890 (2016)

“Functional organization of the HIV lipid envelope”. N. Huarte, P. Carravilla, A. Cruz, M. Lorizate, J.A. Nieto-Garai, H.G. Kräusslich, J. Perez-Gil, J.M. Requejo and J.L. Nieva. Scientific Reports 6, 34190. doi: 10.1038/srep34190 (2016). Selected paper of the month by the SBE September 2016

“Alteration of a second putative fusion peptide of structural glycoprotein E2 of classical swine fever virus alters virus replication and virulence in swine”. L.G. Holinka, E. Largo, D.P. Glaude, V. O’Donnell, G.R. Risatti, J.L. Nieva and M.V. Borca. J. Virol. 90, 10299-10308 (2016)

“Reply to «The broadly neutralizing, anti-HIV antibody 4E10: an open and shut case?»”. E. Rujas, N. Gulzar, K. Morante, K. Tsumoto, J.K. Scott, J.L. Nieva and J.M. Caaveiro. J. Virol. 90, 3276-3277 (2016)

“A diet enriched with plant sterols prevents the memory impairment induced by cholesterol loss in senescence-accelerated mice”. A. Perez-Cañamas, S. Sarroca, C. Melero-Jerez, D. Porquet, J. Sansa, S. Knafo, J.A. Esteban, C. Sanfeliu and M.D. Ledesma. Neurobiol. Aging. 48, 1-12 (2016)

46

“Administration of the TrkB receptor agonist 7,8-dihydroxyflavone prevents traumatic stress-induced spatial memory deficits and changes in synaptic plasticity”. A. Sanz-Garcia, S. Knafo, I. Pereda-Perez, J.A. Esteban, C. Venero and A. Armario. Hippocampus 26, 1179-1188 (2016)

“Specific cytoarchitectureal changes in hippocampal subareas in daDREAM mice”. B. Mellstron, A. Katasnauskaite, S. Knafo, P. Gonzalez, X.M. Dopazo, A. Ruiz-Nuño, J.G. Jefferys, M. Zhuo, T.V. Bliss, J.R. Naranjo and J. De Felipe. Mol. Brain. 29, doi: 10.1186/s13041-016-0204-8 (2016)

“PTEN recruitment controls synaptic and cognitive function in Alzheimer’s models”. S. Knafo, C. Sanchez-Puelles, E. Palomer, I. Delgado, J.E. Draffin, J. Mingo, T. Wahle, K. Kaleka, L. Mou, I. Pereda-Perez, E. Klosi, E.B. Faber, H.M. Chapman, L. Lozano-Montes, A. Ortega-Molina, L. Ordóñez-Gutiérrez, F. Wandosell, J. Viña, C.G. Dotti, R.A. Hall, R. Pulido, N.Z. Gerges, A.M Chan, M.R. Spaller, M. Serrano, C. Venero and J.A. Esteban. Nat. Neurosci. 19, 443-453 (2016)

“Membrane fission by dynamin: what we know and what we need to know”. B. Antonny, C. Burd, P. De Camilli, E. Chen, O. Daumke, K. Faelber, M. Ford, V.A. Frolov, A. Frost, J.E. Hinshaw, T. Kirchhausen, M.M. Kozlov, M. Lenz, H.H. Low, H. McMahon, C. Merrifield, T.D. Pollard, P.J. Robinson, A. Roux and S. Schmid. EMBO J. 35, 2270-2284 (2016)

“Structural basis of phosphatidyl-myo-inositol mannosides biosynthesis in mycobacteria”. E. Sancho-Vaello, D. Albesa-Jové, A. Rodrigo-Unzueta and M.E. Guerin Biochim. Biophys. Acta 5, pii: S1388-1981(16)30303-1. doi: 10.1016/j.bbalip.2016.11.002. (2016)

“Structural basis of glycogen biosynthesis regulation in bacteria”. J.O. Cifuente, N. Comino, J.Madariaga-Marcos, S. Lopez-Fernandez, M. Garcia-Alija, J. Aguirre, D. Albesa-Jové and M.E. Guerin. Structure 6, 1613-1622 (2016)

“The conformational plasticity of glycosyltransferases”. D. Albesa-Jove and M.E. Guerin. Curr. Opin. Struct. Biol. 40, 23-32 (2016)

PU

BLI

CA

TIO

NS

47

“Molecular basis of membrane association by the phosphatidylinositol mannosyltransferase PimA enzyme from mycobacteria”. A. Rodrigo-Unzueta, M.A. Martinez, N. Comino, P.M. Alzari, A Chenal and M.E. Guerin. J. Biol. Chem. 291, 13955-13963. (2016). Selected paper of the month by the SBE July 2016

“Structural basis for selective recognition of acyl chains by the membrane-associated acyltransferase PatA”. D. Albesa-Jové, Z. Svetlíková, M. Tersa, E. Sancho-Vaello, A. Carreras-González, P. Bonnet, P. Arrasate, A. Eguskiza, S.K. Angala, J.O. Cifuente, J. Korduláková, M. Jackson, K. Mikušová and M.E. Guerin. Nat. Commun. 11, 10906. doi: 10.1038/ncomms10906 (2016)

“TssA forms a gp6-like ring attached to the type VI secretion sheath”. S. Planamente, O. Salih, E. Manoli, D. Albesa-Jové, P.S. Freemont and A. Filloux. EMBO J. 35, 1613-1627 (2016)

“Early-onset epileptic encephalopathy caused by a reduced sensitivity of Kv7.2 potassium channels to phosphatidylinositol 4,5-bisphosphate”. M.V. Soldovieri, P. Ambrosino, I. Mosca, M. De Maria, E. Moreto, F. Miceli, A. Alaimo, N. Iraci, L. Manocchio, A. Medoro, M. Passafaro and M. Taglialatela. Scientific Reports 1, 6:38167. doi: 10.1038/srep38167 (2016)

“Lipids and oxidative stress associated with ethanol-induced neurological damage”. J.A. Hernandez, R.C. Lopez-Sanchez and A. Rendon-Ramirez. Oxid. Med. Cell. Longev. 2016, 1543809. doi: 10.1155/2016/1543809 (2016)

“Identification of a membrane-bound prepore species clarifies the lytic mechanism of actinoporins”. K. Morante, A. Bellomio, D. Gil-Cartón, L. Redondo-Morata, J. Sot, S. Scheuring, M. Valle, J.M. González-Mañas, K. Tsumoto, and J.M.M. Caaveiro. J. Biol. Chem. 291, 19210-19219 (2016)

“Biological regulation: controlling the system from within”. L. Bich, M. Mossio, K. Ruiz-Mirazo and A. Moreno. Biol. Philos. 31, 237–265 (2016)

48

“Approaches to polyunsaturated sphingolipids: new conformationally restrained analogs with minimal structural modifications”. I. Nieves, J.L. Abad, L.R. Montes, F.M. Goñi and A. Delgado. Tetrahedron 72, 237-265 (2016)

“Dihydroceramide accumulation mediates cytotoxic autophagy of cancer cells via autolysosome destabilization”. S. Hernández-Tiedra, G. Fabriàs, D. Dávila, I.J. Salanueva, J. Casas, L.R. Montes, Z. Antón, E. García-Taboada, M. Salazar-Roa, M. Lorente, J. Nylandsted, J. Armstrong, I. López-Valero, C.S. McKee, A. Serrano-Puebla, R. García-López, J. González-Martínez, J.L. Abad, K. Hanada, P. Boya, F.M. Goñi, M. Guzmán, P. Lovat, M. Jäättelä, A. Alonso and G. Velasco. Autophagy 12, 2213-2229 (2016)

“Thermotropic properties of ceramides in aqueous or lipidic environments”. A. Alonso and F.M. Goñi. In: “Biocalorimetry. Foundations and contemporary approaches” (M. Bastos, ed.). CRC Press, Boca Raton, FL, USA, pp. 137-151 (2016)

“Triatomines intrahaemocoelic inoculation protocol: a useful tool to check infectivity in insects”. G.S. Rozas-Denis, G.A. Marti, N.L. Cifuentes, F. Guhl and D.M.A. Guérin. J. Biol. Methods 3(2), e40. DOI: 10.4440/jbm.216.46 (2016)

“Reflections on soil contamination research from a biologist’s point of view”. M.T. Gomez-Sagasti, L. Epelde, I. Alkorta and C. Garbisu. Applied Soil Ecology 105, 207-210 (2016)

“Synthetic biology as a challenge to understand the autonomy of the living”. S. Murillo-Sanchez and K. Ruiz-Mirazo. Isegoría 55, 551-575 (2016)

PU

BLI

CA

TIO

NS

49

7.4. Conferences and courses

7.4.1. Organization of meetings

9th More Medicines for Tuberculosis. MM4TB-EU-FP7 Consortium Meeting

January 8-9, 2015. Bilbao, Spain

M. Guerin. Co-Organizer

Physical Virology: From Structure to Evolution and III Reunión de la Red Española de Biofísica de Virus

March 9-11, 2015. Bilbao, Spain

D.M.A. Guérin. Co-Organizer

XXXVIII Congreso de la Sociedad Española de Bioquímica y Biología Molecular

September 7-10, 2015. Valencia, Spain

I. Alkorta. Executive Committee and Co-Organizer

Symposium “Novel Perspectives in Molecular and Cellular Cognition” in 16th National Congress of the Spanish Society of Neuroscience

September 23-25, 2015. Granada, Spain

S. Knafo. Co-Organizer and Chair

Symposium “Biophysics of proteins at surfaces: assembly, activation, signaling” in Biophysical Society Thematic Meeting

October 13-15, 2015. Madrid, Spain

F.M. Goñi. Co-Organizer

50

Simposio Satélite de Triatoma virus (TrV) in XXIV Congresso Brasileiro de Parasitología e XXII Congresso Latinoamericano de Parasitologia (FLAP)

October 27-31, 2015. Salvador de Bahía, Brazil

D.M.A. Guérin. Co-Organizer

Symposium of Translational Imaging Euskampus – Bordeaux

November 26-27, 2015. Donostia-San Sebastián, Spain

B. Larijani. Co-Organizer

International Workshop: Doença de Chagas no Estado do Rio Grande do Norte

July 14-15, 2016. Natal, RN, Brasil

D.M.A. Guérin. Co-Organizer

XXXIX Congreso de la Sociedad Española de Bioquímica y Biología Molecular

September 5-8, 2016. Salamanca, Spain

I. Alkorta. Executive Committee and Co-Organizer

Spanish-Portuguese Meeting for Advanced Optical Microscopy (SPAOM2016). (http://www.spaom2016.eu/)

October 5-7, 2016. Bilbao, Spain

J. Requejo-Isidro. Co-Organizer

51

7.4.2. Invited talks

Biophysical Society. 59th Annual Meeting February 7-11, 2015. Baltimore, MD, USA

F.M. Goñi. “Ceramide and cholesterol effects on phospholipid bilayers under the AFM: characterization of complex lipid phases”

A. Alonso. “End-Product diacylglycerol enhances activity of phosphatidylinositol phospholipase C through changes in membrane lipid domain structure”

C. Gomis. “PIP2 and surface expression underlie Apo-Calmodulin dependent Kv7.2/KCNQ2 current potentiation

A. Alberdi. “Disruption of assembly/calmodulin-binding coupling and calmodulin-dependent potentiation of kv7.2 channels by a epileptogenic helix d mutation”

G. Bernardo. “Calmodulin binding to a novel site in the ab module of kv7.2 subunits regulates surface expression”

Disertación en la toma de posesión como Académico Correspondiente de la Real Academia Nacional de Farmacia February 26, 2015. Madrid, Spain

F.M. Goñi. “Las membranas como fronteras celulares: aduanas y contrabandistas”

Physical Virology: From Structure to Evolution March 9-11, 2015. Bilbao, Spain

D.M.A. Guérin. “Triatoma Virus (TrV) disassembly: Hypothetical roles of structural proteins in triggering capsid dismantling and in cell membrane disruption.”

ImagineNano 2015March 12-13, 2015. Barakaldo, Spain

L. Arana. “Solid lipid nanoparticles for delivery of calendula extracts”

Nanopore Meeting 2015March 23-27, 2015. Lenzerheide, Switzerland

D. Rodríguez-Larrea. “Protein unfolding, translocation and refolding through nanopore membrane pores”

54

Programa Oficial de Postgrado “Biología Celular y Molecular” de la Universidad de MálagaApril 10, 2015. Málaga, Spain

F.M. Goñi. “Avances recientes en la estructura y dinámica de las membranas celulares”

Factor universitario 2015. Universidad de Sevilla, CICUS. La investigación y la transferencia de conocimiento April 13-15, 2015. Sevilla, Spain

F.M. Goñi. “La necesidad de generar conocimiento”

Ikergazte 2015. Nazioarteko Ikerketa euskaraz May 13-15, 2015. Durango, Bizkaia, Spain

L. Arana. “Lipido solidozko nanopartikulak substantzia liposolugarrien garraio eta egonkortasuna hobetzeko”

Instituto de Higiene e Medicina Tropical May 15, 2015. Lisbon, Portugal

D.M.A. Guérin. “Triatoma virus as viral model and biotechnological tool to fight infectious diseases”

XV Congress of the Spanish Biophysical Society June 10-12, 2015. Granada, Spain

V. Frolov. “Nanomechanics of energy transduction in protein-driven membrane fission”

F. Moro. “Chaperoning protein aggregates: the disaggregase machinery”

Tel Aviv University Alzheimer’s International Conference June 2015. Tel Aviv University, Israel

S. Knafo. “PTEN controls synaptic and cognitive function in AD models”

Emergence in chemical systems 4.0. University of Alaska at Anchorage – Jerzy Maselko groupJune 22-27, 2015. Anchorage, Alaska, USA

K. Ruiz-Mirazo. “Emergent chemical behaviour in variable-volume protocell”

55

40th FEBS Congress “The Biochemical Basis of Life”July 4-9, 2015. Berlin, Germany

J.A. Nieto-Garai, E. Bilbao, F.X. Contreras, M. Lorizate. “Studying HIV-1 envelope lipid environment using photoactivatable lipids”

SIMUNE July 6, 2015. San Sebastian, Spain

D.M.A. Guérin. “Triatoma virus as viral model and new nanomaterial”

8th International symposium on two-dimensional correlation spectroscopy 2DCOS–8July 9-11, 2015. Vienna, Austria

J.L.R. Arrondo. “A study of protein aggregation by 2DCOS”

10th European Biophysical Congress EBSA July 18-22, 2015. Dresden, Germany

J.L. Nieva. “Membrane destabilization by the HIV-1 gp41 MPER-TMD region: Mechanism and blocking by antibodies”

The 29th annual Symposium of the Protein SocietyJuly 22-25, 2015. Barcelona, Spain

D. Rodríguez Larrea. “Single-molecule vectorial protein folding and unfolding through membrane pores”

G. Bernardo. “Structural characterization of calmodulin bound to the intracellular calmodulin binding domain of Kv7.2 channels by NMR”

Gordon Research Conference. Cellulosomes, Cellulases & Other Carbohydrate Modifying Enzymes August 2-7, 2015. Andover, NH, USA

D. Albesa-Jové. “Structural basis of chitin oligosaccharide deacetylation”

Fondation des Treilles. Membrane fission: Understanding the mechanism of action of dynamin August 24-29, 2015. Provence-Alpes-Côte d’Azur, France

V. Frolov. “Bimodal nature of protein-driven membrane fission”

56

XXXVIII Congreso de la Sociedad Española de Bioquímica y Biología Molecular September 7-10, 2015. Valencia, Spain

F.M. Goñi. “Un estudio racional de los rafts de membranas, basado en diagramas de temperatura/solubilización”

International Conference on the Bioscience of Lipids (ICBL) September 22-26, 2015. Puerto Iguazú, Misiones, Argentina

F.M. Goñi. “Ceramides and diacylglycerols as modulators of membrane physical properties”

2015 – Meeting of the Italian Society for Artificial Life September 23-24, 2015. University of Bari, Bari, Italia

K. Ruiz-Mirazo. “Major transitions in prebiotic evolution: protocell systems in vitro and in silico”

European Helicobacter and Microbiota Study Group – EHMSG. XXVIIIth International Workshop on Helicobacter & Microbiota in Inflammation & Cancer September 24-26, 2015. Nicosia, Cyprus

H. Luecke. “Structure, function, and inhibitors of the acid-gated Helicobacter pylori urea channel, an essential component for acid survival and chronic infection”

Workshop of biomaterials and their interaction with biological and model membranes October 19-22, 2015. Salou, Tarragona, Spain

V. Frolov. “Nanomechanics of membrane fission”

Biophysical Society Thematic Meeting: “Biophysics of Proteins at Surfaces: Assembly, Activation, Signalling” October 13-15, 2015. Madrid, Spain

A. Alonso. “The interaction of autophagy proteins with lipid surfaces”B. Larijani. “Protein kinase B (PKB) and phosphoinositide dependent

kinase 1 (PDK1) regulation at membranous compartments”

57

Organelle Crosstalk in Membrane Dynamics and Cell Signalling October 26-29, 2015. Edinburgh, UK

B. Larijani. “Effects of phosphoinositides and their derivatives on membrane morphology and function”.

XXIII Congreso Latinoamericano de Parasitología October 27-31, 2015. Salvador, Brasil

D.M.A. Guérin. “Chimeric VLP from Triatoma virus: a new technology to develop vaccines against Chagas”

Seminars at the University of La Laguna November 3, 2015. La Laguna, Tenerife, Spain

S. Knafo. “Novel roles for PTEN in the nervous system”

International Conference on Vaccines Research and DevelopmentNovember 2-4, 2015. Baltimore, USA

D.M.A. Guérin. “A new approach on VLP-based vaccine design: Chagas disease as test case”

Latin American Crosstalk in Biophysics and Physiology. SBF.uy-SAB November 26-29, 2015. Salto, Argentina

F.M. Goñi. “Novel 1-deoxy-(dihydro)ceramides occurring in mammalian cells”

Euskampus - Bordeaux Symposium November 26-27, 2015. Donostia-San Sebastian, Spain

B. Larijani. “Oncoprotein activation and dynamics in cancer: A quantitative imaging approach”

Seminars at CIMA November 16, 2015. Pamplona, Spain

S. Knafo. “PTEN’s Role in sociability”

Seminars at the Institut Pasteur, Montevideo December 22, 2015. Montevideo, Uruguay

D.M.A. Guérin. “Triatoma Virus (TrV): Part II: A new Virus-like Particle (VLP) platform for development of vaccines”

58

Seminars at the Universidad Nacional del Sur January 29, 2016. Bahía Blanca, Argentina

D.M.A. Guérin. “Triatoma Virus (TrV): Part I: Capsid disassembly and cell membrane permeation Part II: A new Virus-like Particle (VLP) platform for development of vaccines”

Seminars at the Hebrew University of JerusalemFebruary, 2016. Jerusalem, Israel

S. Knafo. “Why do Alzheimer’s patients lose their memory”

BCAM Workshop “Quantitative Biomedicine for Health and Disease” February 24-25, 2016. BCAM, Bilbao, Spain

B. Larijani. “Oncoprotein activation and dynamics in cancer. A quantitative imaging approach”

Biophysical Society 60th Annual Meeting February 27-March 2, 2016. Los Angeles, CA, USA

F.M. Goñi and A. Alonso. “Ceramide studies from the nano- to the microscale”

V. Frolov. “Nanomechanics of membrane fission mediated by Dynamin 1”

7th Annual Meeting of the EFOR Network March 7-8, 2016. Paris, France

B. Larijani. “Nuclear envelope biogenesis and female and male ..............pronuclei fusion mechanisms in echinoderms”

III Biennial Meeting of the Chemical Biology Group and XII Carbohydrate Symposium March 14-16, 2016. CIB-CSIC, Madrid, Spain

M. Guerin. “Membrane enzymes: the structural basis of phosphatidylinositol mannosides biosynthesis in Mycobacteria”

59

Kickoff meeting of the 216RT0506 CYTED action (www.cyted.org/es/A2salud)March 20-30, 2016. Sao Paulo University, Brazil

D.M.A. Guérin. “Red iberoamericana para el desarrollo en base a micromecenazgo de vacunas contra enfermedades infecciosas con tecnología en plataforma VLP”

Mujeres y Ciencia (V Jornadas de Investigación FCT) April 7, 2016. Leioa, Bizkaia, Spain

I. Alkorta. “Mesa redonda: mujer investigadora”

SysChem2016 (CM 1304 COST Action Meeting) May 8-12, 2016. Valtice, Czech Republic

K. Ruiz-Mirazo. “Integrating prebiotic peptide chemistry and fatty acid self-assembly dynamics: a crude but realistic ‘bottom-up’ approach to biogenesis”

PKSymposium (Celebrating the 75th Anniversary of Peter Schuster) Chemolution: from chemistry to evolution May 19-20, 2016. Vienna, Austria

K. Ruiz-Mirazo. “A new scenario to address the problem of origins of life: the ‘systems chemistry’ challenge”

Meeting of the Groupe Francais de Glycosciences - GFG 2016 May 23-27, 2016. Aussois, France

M. Guerin. “Membrane enzymes: the structural basis of phosphatidylinositol mannosides biosynthesis in Mycobacteria”

International Workshop Understanding Life: new perspectives from philosophy and biologyMay 26-27, 2016. University of Bern, Bern, Switzerland

K. Ruiz-Mirazo and Alvaro Moreno. “Autonomy and open-ended evolution: epistemological bases for a universal biology”

60

Beilstein Symposium 2016: ‘Chemistry, Life and Evolution’ May 31- June 2, 2016. The Beilstein Institute, Prien, Germany

K. Ruiz-Mirazo. “Major prebiotic transitions as stages of protocellular development”

5th International Iberian Biophysics Congress June 15-17, 2016. Oporto, Portugal

B. Larijani. “Effects of phosphoinositides and their derivatives on membrane morphology and functions”

D. Rodriguez-Larrea. “Single-molecule analysis of proteins with nanopore technology”

CRG Conferences. Scientific Seminars of the Group Leaders of the Centers of the Park May 18, 2016. Barcelona, Spain

F.M. Goñi. “You say you work on LIPIDS?”

10th FENS Forum of Neuroscience June 30-July 1, 2016. Copenhagen, Denmark

A. Ouro. “Tachykinin Receptor 3: a link between anxiety and maturity”S. Knafo. ”PTEN recruitment controls synaptic and cognitive function

in Alzheimer’s models”

EMCCS-FENS 7thbiannual meeting and 1stEBBS -EMCCS join meeting (A satellite event of the FENS Forum 2016) June 30-July 1, 2016. Copenhagen, Denmark

S. Knafo. “Bidirectional control of sociability with genetic tools”

Workshop Doença de Chagas no Estado do Rio Grande do Norte July 14-15, 2016. Natal, Brazil

D.M.A. Guérin. “Development of vaccines against Chagas: Need of new approaches to address old bottlenecks”

2016 Institute of Protein Biochemistry (IBP) Seminar Series July 19, 2016. Naples, Italy

F.M. Goñi. “The basic structure and dynamics of cell membranes: an update of the Singer-Nicolson model”

61

XXXIX SEBBM CongressSeptember 5-8, 2016. Salamanca, Spain

G. Celaya. “Label-free single-molecule analysis of protein-DNA complexes with nanopores”

O. Morana. “IFN-š receptor signalling is critically dependent on its location in lipid nanodomains” (Poster and selected talk)

S. Bañuelos. “Recognition of NES cargoes by CRM1 exportin is altered in certain leukemias”

S. Knafo. “PTEN recruitment controls synaptic and cognitive function in Alzheimer’s models”

X. Contreras. “Glycosylation-dependent partitioning of IFN-š receptor in lipid and actin nanodomains is critical for JAK/STAT signalling”

D. Rodriguez Larrea. “Single-molecule analysis of proteins with nanopore technology”

FEBS Advanced Course: Lipid-protein interactions and organelle function September 1-8, 2016. Spetses Island, Greece

Z. Antón, A. Landajuela, J.H. Hervás, L.R. Montes, S. Hernández-Tiedra, G. Velasco, F.M. Goñi and A. Alonso.“Mitochondrial membrane association of human Atg8 proteins during mitophagy”

EMBO Conference Tuberculosis 2016 September 19-23, 2016. Institut Pasteur, Paris, France

M. Guerin.”Structural basis of phosphatidylinositol mannosides biosynthesis in Mycobacteria”

Boden Research Conference “Animal, Vegetal, Mineral” September 19-23, 2016. Yallingup, Western Australia

V. Frolov, A. Velasco del Olmo, P.V. Bashkirov and A.V. Shnyrova. “Nanoscale self-assembly during membrane remodeling”

SPAOM. Spanish-Portuguese Meeting for Advanced Optical MicroscopyOctober 5-7, 2016. Bizkaia Aretoa, Bilbao, Spain

V. Frolov. “How biomimetic nanotemplates help resolving molecular details of cellular membrane fission”

62

First Joint WGs Meeting of TRANSAUTOPHAGY COST Action CA15138 October 6-7, 2016. Warsaw, Poland

Z. Antón, A. Landajuela, J.H. Hervás, L.R. Montes, S. Hernández-Tiedra, G. Velasco, F.M. Goñi and A. Alonso. “Human Atg8-cardiolipin interactions in mitophagy: Specific properties of LC3, GABARAPL2 and GABARAP”

Asociación de afectados por la enfermedad del Chagas, voluntarios y amigos (ASAPECHAVAE) October 15, 2016. Valencia, Spain

D.M.A. Guérin. “Proyecto internacional RedVLP para el desarrollo de una vacuna contra Chagas”

Workshop chaperones in the maintenance of cellular proteostasis October 17-19, 2016. Baeza, Jaén, Spain

F. Moro. “Remodeling of RepE conformation by DnaK and DnaJ”

Red de Excelencia SICI Consolider October 20-22, 2016. Torrecaballeros, Segovia, Spain

A. Villarroel. “The assembly domain couples calmodulin binding and PIP2 regulation of Kv7.2 channels”

IV CNIC Conference “Mechanical forces in physiology and disease” November 4-5, 2016. CNIC, Madrid, Spain

V. Frolov. “Mechanochemistry of membrane fission driven by dynamins”

XLII Congreso de Químicos Teóricos de Expresión Latina (QUITEL)November 20-25, 2016. Montevideo, Uruguay

D.M.A. Guérin. “Multiscale Modelization in a Small Virus: Mechanism of proton channeling and its role in triggering capsid disassembly”

NanoBio&Med2016 November 21-24, 2016. Barcelona, Spain

L. Arana. “Solid lipid nanoparticles for delivery of calendula officinalis extract”

63

IIILAFeBS, IX IberoAmerican Congress of Biophysics, XLV SAB Annual MeetingNovember 23-25, 2016. Tucumán, Argentina

Z. Antón, J.H. Hervás, A. Landajuela, L.R. Montes, S. Hernández-Tiedra, G. Velasco, F.M. Goñi and A. Alonso. “Role of lipids in autophagy events”

Seminarios de Inmunología Facultad de Farmacia y Bioquímica Universidad de Buenos Aires December 1, 2016. Buenos Aires, Argentina

D.M.A. Guérin. “Ibero American network for the development of VLP-based vaccine: A novel cooperative strategy to obtain a vaccine against Chagas disease”

Cuarto encuentro Vasco-Chileno de investigación biomédica December 1-2, 2016. Leioa, Bizkaia, Spain

I. Alkorta. “Inhibidores de la conjugación bacteriana como nueva vía para la terapéutica antibiótica”

C. Martín. “Mecanismos moleculares de hipercolesterolemia familiar”

25th ISFN Annual Meeting & the joint Israel-India Neuroscience symposium December 3-6, 2016. Eliat, Israel

S. Knafo. ”PTEN-PDZ interaction as a new target for the treatment of Alzheimer’s disease”

Centre de Recherches des Membranes et des Nano-objets (CNRS) December 8, 2016. Burdeos, Francia

F.M. Goñi. “Physical properties of ceramides in lipid bilayers”

Type IV secretion in Gram-negative and Gram-positive bacteria December 8-11, 2016. Beilngries, Germany

I. Alkorta. “Coupling proteins as key elements against the spread of antibiotic resistance”

64

The History of Autophagy (Tübingen Workshop) December 14-16, 2016. Interfaculty Institute of Cell Biology, Tübingen, Germany

J.H. Hervás, A. Landajuela, Z. Antón, L.R. Montes, D. Gil, M. Valle, F. Rodriguez, F.M. Goñi and A. Alonso. “Biophysical membrane properties modulate LC3/GABARAP-mediated autophagosome elongation”

Hospital Interzonal Dr. J. Penna December 19, 2016. Bahía Blanca, Argentina

D.M.A. Guérin. “Proyecto internacional RedVLP para el desarrollo de una vacuna contra Chagas”

2016 Cajal Xmas MeetingDecember 22, 2016. Cajal Institute, Madrid, Spain

S. Knafo. “New tools for improving cognitive functioning”

7.4.3. Free communications

Members of the Instituto Biofisika have presented communications at

conferences, 43 at international and 17 at national events, among which

we should highlight contributions to the 59th Annual Meeting of the

Biophysical Society, Baltimore, MD, USA (2015), and the 60th Annual

Meeting of the Biophysical Society, Los Angeles, CA, USA (2016)

and the XXXVIII Congress of the Spanish Society for Biochemistry

and Molecular Biology, SEBBM held in Valencia, Spain (2015) and

the XXXIX Congress of the Spanish Society for Biochemistry and

Molecular Biology, SEBBM held in Salamanca, Spain (2016).

65

7.4.4. BioForo

Professor A. Alonso has organised the Seventh (2015) and Eighth (2016) series of BioForo Lectures at the Faculty of Science and Technology (UPV/EHU) with participation of the following researchers:

25 February 2015. George Banting. Faculty of Medical and Veterinary Sciences. University of Bristol. “Membrane microdomains and membrane tubules: the roles of Tetherin and ARHGAP44”

26 March 2015. Paul Blank. NHICD/NIH, Bethesda, USA. “The brain on blast”

22 April 2015. Laura Lechuga. Research Centre on Nanoscience and Nanotechnology CIN2 (CSIC), Barcelona. “Nanophotonic lab-on-chip biosensors as interactive diagnostics tools for advanced healthcare”

12 May 2015. Manu Ben Johny. John Hopkins Biomedical Engineering, Baltimore, USA. “Counting with FRET: Detecting the stoichiometry of macromolecular complexes in live cells”

13 May 2015. Christian Eggeling. Weatherall Institute of Molecular Medicine. Oxford University, UK. “Studying molecular plasma membrane dynamics with super-resolution STED microscopy”

1 July 2015. Iban Ubarretxena-Belandia. PhD. Icahn School of Medicine at Mount Sinai New York. “Structural biology of neurodegerative disorders”

11 September 2015. Jens Coorssen. University of Western Sydney, Australia. “Calcium-triggered exocytosis: New experimental approaches”

7 October 2015. Griselda Irusta. Lab. de Fisiología y Biología Tumoral del Ovario – IBYME-CONICET, Buenos Aires, Argentina. “Biología tumoral del ovario: efectos de un inhibidor de la gama-secretasa y del PDGF(B)”

67

4 November 2015. Albert Pol. Institut d’Investigacions Biomèdiques August Pi i Sunyer (IDIBAPS), Universitat de Barcelona. “Burning the fat: When lipid-droplets meet”

11 November 2015. David Vaux. Sir William Dunn School of Pathology, Oxford. “Dynamics and resolution of the nucleoplasmic reticulum”

18 November 2015. Luis Liz Marzan. CIC Biomagune, Donostia-San Sebastián. “Usando luz para escuchar el lenguaje de las bacterias”

10 December 2015. Xosé Puente. Universidad de Oviedo. “Non-coding recurrent mutations in chronic lymphocytic leukemia”

16 December 2015. Workshop “Bioscience by Ikerbasque Researchers”

- Juan Anguita. CIC bioGUNE, Derio, Bizkaia. “Macrophage responses to the Lyme spirochete: destruction and inflammation”

- Lourdes Basabe-Desmonts. Lascaray Research Center, UPV/EHU, Vitoria-Gasteiz. “Lab on a chip, miniaturized analytical platforms”

- Maria Cruz Rodríguez-Oroz. BioDonostia Research Institute, Donostia. “Parkinson’s disease from a translational perspective”

- Daniel Marino. Department of Plant Biology and Ecology, UPV/EHU, Leioa. “New insights on ammonium stress response of Arabidopsis thaliana model plant”

- Charles Lawrie. BioDonostia Research Institute, Donostia. “Cancer and dark matter: An omics approach to biomarker and therapeutic target discovery”

9 March 2016. Félix Campelo. IFCO Institute of Photonic Sciences, Barcelona. “Golgi membrane compartmentalization: biophysical aspects and physiological implications”

14 March 2016. Sergio Pérez Acebrón. German Cancer Research Center in Heidelberg, Germany. “New insights into Wnt signal transduction”

68

23 March 2016. Eva Benito. German Center for Neurodegenerative Diseases (DZNE), Göttingen, Germany. “Aging from a genomics perspective: lessons from the genome and the epigenome”

15 April 2016. Aurora Martinez. University of Bergen, Norway. “Development of molecular chaperones in neurometabolic disorders”

11 Mayo 2016. Christopher Burd. Cell Biology, Yale School of Medicine, New Haven, USA. “New insights into lipid trafficking within cells”

23 May 2016. Jordi Berenguer. Cancer Center Amsterdam VU University Medical Center, The Netherlands. “Intercepting exosome transfer in glioblastoma by receptor targeting”

20 June 2016. Tannishtha Reya. University of California-San Diego School of Medicine, USA. “Stem cell signals in cancer heterogeneity and therapy resistance”

14 September 2016. María Aguirre. Directora de Investigación e Innovación Sanitarias, Gobierno Vasco., Vitoria-Gasteiz. “Inversión en I+D e innovación en salud: una apuesta para crecer”

19 October 2016 . Ana Carrera. CNB-CSIC, Madrid. “How to win Alexander: the p85beta PI3K regulatory subunit in cancer”

2 November 2016. Lorena Redondo. Bio-AFM Lab, INSERM / Aix-Marseille Université, France. “Protein-induced membrane deformations studied by high-speed atomic force microscopy”

9 November 2016. Michael Wakelam. Babraham Institute, Cambridge, UK. “Metabolic and signalling changes in cancer determined through lipidomics”

16 November 2016. Aitziber Lopez Cortajarena. CIC Biomagune, Donostia. “Designed proteins as platforms for functional nanostructures and biomaterials”

69

17 November 2016. Ivan Huc. IECB, Burdeos, France. “Aromatic mimics of biomolecular folding”

30 November 2016. Albert Quintana. Department of Cellular Biology, Physiology and Immunology. Institut de Neurociències. Faculty of Medicine, Universitat Autònoma de Barcelona (UAB), Barcelona. “It is all about energy: Neuropathology in mitochondrial disease”

15 December 2016. Jose Castro Tubio. University of Vigo. “Contagious cancer metastases: the ultimate parasite”

16 December 2016. Udo Bläsi. Vienna University, Austria. “The interplay between Hfq and Crc in RNA-mediated regulation of metabolism and virulence traits in Pseudomonas aeruginosa”

21 December 2016. Workshop “Current Studies on Biomembranes”

- Lucy Collinson. The Francis Crick Institute, London, U.K. “Imaging biomembranes with 3D correlative light and electron microscopy”

- María García Parajo. ICFO, Intitute of Photonic Sciences, Barcelona. “Membrane receptor nanoclustering as functional unit of immune cells: from nanoscopy to single molecule dynamics”

- Juan Carmelo Gómez Fernández. Department of Biochemistry and Molecular Biology A, University of Murcia. “Lipid regulation of protein kinases C activity”

- Pedro Carvalho. Sir William Dunn School of Pathology. University of Oxford, U.K. “Border patrol- regulation of membrane function and identity by ubiquitin dependent proteolysis”

- Felix Wieland. BZH, Biochemistry Center, Heidelberg University, Germany. “Molecular mechanisms of vesicular transport: What do we learn from Biochemistry and from Structural Biology?”

70

7.4.5. Science dissemination

In this chapter we include all the contributions (oral and written) of Instituto Biofisika members.

Conferences

Darwin Day (Bilbao, February 12, 2015) was organized by the UPV/EHU in collaboration with CIC bioGUNE, Instituto Biofisika (CSIC, UPV/EHU), Círculo escéptico and Center for inquiry). The speakers were Ambrosio García Leal (biologist and scientific writer) and María Martinón Torres (Centro Nacional de Investigación sobre la Evolución Humana).

F.M. Goñi “Hacer ciencia, ¿Cómo? ¿Para qué?” (Invited talk). XV week of Science. (October 2, 2015) Bilbao, Spain

H. Ostolaza “Adenilato ziklasa toxinak bakterioen barneratzea eragiten du zelula ez-fagozitikoetan” (Invited talk). Ikertzaile Durango 2015. (January 1, 2015) Durango, Spain

C. Martin “Hiperkolesterolemia familiarra: LDLR, APOB eta PCSK9-en mutazioen balioztapen funtzionala diagnostiko zehatz baterako” Ikertzaile Durango 2015. (January 1, 2015) Durango, Spain

F.M. Goñi “Ciencia y tecnología en la sociedad actual” (Invited talk). Summer Courses UPV/EHU. (June 15, 2015) Donostia, Spain.

X Contreras “Ciencia y nomadismo” (Invited talk). Science+Bilbao 2015. (May 7, 2015) Bilbao, Spain.

F.M. Goñi “La Sociedad Española de Bioquímica y Biología Molecular (SEBBM): historia y logros” (Invited talk). Science+Bilbao 2015. (May 7, 2015) Bilbao, Spain.

F.M. Goñi participated in the professional volunteer program Lanaldi 2015. Lanaldi, is a program of the Novia Salcedo Foundation that is aimed at young students of 16 years to know a day in the professional life of a professional.

72

I. Alkorta “Motores moleculares” (Invited talk). Conference cycle Jakin-mina Jakiunde. (February 27, 2015) Bilbao, Spain.

I. Alkorta “Motores moleculares y las infecciones bacterianas” (Invited talk) Conference cycle Scienec Week, Instituto Miguel de Unamuno. (December 15, 2015) Bilbao, Spain.

K. Ruiz-Mirazo Participation in a scientific debate on synthetic biology with Ricard Solé and moderated by Luis Quevedo (November 04, 2015) (http://naukas.com/2015/11/03/22a-tertulia-media2ciencia-biologia-sintetica/)

Darwin Day was organized by the UPV/EHU in collaboration with CIC bioGUNE, Instituto Biofisika (CSIC, UPV/EHU), Círculo escéptico and Center for inquiry (Bilbao, February 12, 2016). The speakers included Carmen Manzano (UPV/EHU) y Diego Garate (Museo Arqueológico de Bizkaia).

Articles

I. Alkorta “Medicina en nanogotas” SEBBM Divulgación, El profesor de ciencias, (August 2015). (http://www.sebbm.es/web/images/archivos/archivos_tinymce/agosto2015_itziaralkorta.pdf)

A. Alonso “Ceramidas: no sólo en las cremas de belleza” SEBBM Divulgación, Acércate a nuestros científicos, (March 2015). (http://www.sebbm.es/web/es/divulgacion/acercate-nuestros-cientificos/284-alicia-alonso-marzo-2015-ceramidas)

K. Ruiz-Mirazo Contribución al blog de divulgación y cultura científica ‘mapping ignorance’, (April 4, 2015). (http://mappingignorance.org/2015/04/27/opening-the-systemic-avenue-from-chemistry-to-biology/)

73

7.5. Governing bodies

I. Alkorta continued to serve as Vice-Dean of the Facultad de Ciencia y Tecnología, in charge of Science Communication (until July, 2015).

I. Alkorta has been appointed new Director of the Instituto Biofisika (UPV/EHU, CSIC) (since July 2015).

I. Alkorta continued as Consul for the Basque Country of the Spanish Society of Biochemistry and Molecular Biology (SEBBM).

I. Alkorta continued as Chair of the Committee of the SEBBM.

I. Alkorta has started as Editorial Board of SEBBM Journal (from January 2016).

I. Alkorta has started as Member of the Campus Board of Bizkaia. Representative of Directors of the University Research Institutes (from 21 October 2016).

I. Alkorta was the Representative of the Instituto Biofisika at the Plataforma Española de Nanomedicina.

A. Alonso was elected as Secretary General of COSCE (Confederación de Sociedades Científicas de España) (since April 2015).

F.M. Goñi continued as a Member of the Jury of the “Iñigo Álvarez de Toledo” Award for Basic and Clinical Research in Nephrology (since 2003).

F.M. Goñi continued as Chair of the International Relations Committee of the Biophysical Society (USA) for a three-year term (July 1, 2013–June 30, 2016).

F.M. Goñi was appointed as Chair of the Spanish Society for Biochemistry and Molecular Biology (SEBBM) (since September 2016).

76

D.M.A. Guérin was elected as a Member of the International Committee of Taxonomy of Viruses, Dicistroviridae/Iflaviridae Study Group 2014-2017 (http:///www.ictvonline.org)

S. Knafo was appointed as Chair of the A satellite event of the FENS Forum 2016.

S. Knafo was appointed as Chair of the Joint Conference, Verona, Italy.

S. Knafo was appointed as Chair of the Molecular and Cellular Cognition Symposium in the SENC meeting, Granada, Spain.

S. Knafo was invited as expert in the Research Prioritization Exercise in Dementia, The World Health Organization (WHO).

S. Knafo participated in the Scientific Council Marie Sklodowska-Curie Individual Fellowships (H2020-MSCA-IF-2016) - LIF Panel.

C. Martin started to serve as the Academic Secretary of the Department of Biochemistry and Molecular Biology (until 1 July, 2016).

C. Martin was elected as Head of the Department of Biochemistry and Molecular Biology (since 1 July, 2016).

C. Martin was elected as a Member of the International Committee of ClinGen Familial Hypercholerolemia (ClinGen FH Expert Panel- Worldwide FH GENETICS database, NIH effort).

J.L. Nieva continued to serve as Head of the Department of Biochemistry and Molecular Biology (until 1 July, 2016).

J.L. Nieva started to serve as the Academic Secretary of the Department of Biochemistry and Molecular Biology (since 1 July, 2016).

A. Villarroel has been appointed new Vice-Director of the Instituto Biofisika (UPV/EHU, CSIC) (since September 2015).

77

7.6. Scientific Journals and Committees

A. Alonso continued to serve as a member of the Editorial Committee of Biophysical Reviews.

F.M. Goñi continued to serve as a member of the Editorial Advisory Board of Chemistry and Physics of Lipids (Elsevier), the Journal of Chemical Biology, (Springer) and of the scientific magazine CIC-Network.

F.M. Goñi continued to serve as a member of the Editorial Committee of the Annual Review of Biophysics.

F.M. Goñi was an evaluator for the 2016 European Research Council Advanced Grants.

S. Knafo acted as Editor in the special issue Molecular and cellular mechanisms of cognitive function, Neuroscience.

C. Martin became member as Associate Editor of the Scientific Reports.

K. Ruiz-Mirazo became member of the Editorial Board of Origins of Life and Evolution of Biospheres.

K. Ruiz-Mirazo became Evaluator of the research projects into the NASA Exobiology Program (Nov-Dec 2015)

J.M.G. Vilar continued to serve as Associate Editor of BMC Systems Biology.

78

7.7. Other activities

CIC BioGUNE-Instituto Biofisika meeting

June 6, 2016

An interactive meeting with researchers of both centers to foster scientific collaborations was held at Instituto Biofisika.

Achucarro Basque Center for Neuroscience -Instituto Biofisika meeting

July 7, 2016

An interactive meeting to foster collaborations between both centers was held at Instituto Biofisika.

Seminar about intellectual property protection and spin-offs creation

September 13, 2016

The seminar was aimed at all kinds of personnel: students, grantees, technical and research staff to know about the actions and responsibilities of the VATC/OTRI that have to do with the protection of research results and the creation of spin-off.

Gloria Totoricagüena, Director of the Center for Basque Studies of the University of Nevada-Reno

October 10, 2016

Gloria Totoricagüena and the Rector of UPV/EHU, Iñaki Goirizelaia, visited us within the program of Bizkaia Provincial Council “Bizkaia Talent” to stablish relationships between organizations, companies, and universities of both countries.

79

Researchers

Hasna Ahyayauch, Institut Supérieur des Professions Infirmières et des Techniques de Santé Rabat, Rabat, Marruecos. July 2016-August 2016.

Pavel Bashkirov, Research Institute for Physico-Chemical Medicine, Moscow, Russia, October 2016.

Ana M. Bouchet, Nutrition, Croissance et Cancer. Université François Rabelais, Tours, France. July 2016-August 2016.

María Marta Branda, Instituto de Física del Sur [CCT-CONICET-Bahía Blanca], Bahía Blanca, Argentina. October 2016-November 2016.

Francisco Galisteo, Departamento de Física Aplicada, Universidad de Granada, Granada, Spain. September 2016-August 2017.

Students

Placement Student from University of Bath (Academic year 2015-2016): James Miles, Alice Haighton

Placement Student from University of Naples (2015): Stefano de Tito

Placement Student from University of Málaga (2015): Carlos Acosta Andrade

Placement Student from University of Zaragoza (2016): José Daniel Camino Camino

Placement Student from University of Bath (Academic year 2016-2017): Emma Tripp, Katerina Withers, Maddy Parker

Placement students from University of Bristol (2016-2017): Hema Randev, Polly Machin, Kieran Mclaverty

8. Biofisika Visitors Programme

81

(Until 1999, Biomembrane Group of the Department of Biochemistry, UPV/EHU)

José Ignacio García Gurtubay (1979)

Alicia Alonso Izquierdo (1981 )

Mª Carmen Barbero (1981)

Mª Ángeles Urbaneja Arrúe (1984)

José María Valpuesta Moralejo (1985)

Arturo Muga Villate (1988)

Juan Manuel González Mañas (1989)

María Aránzazu Partearroyo (1989)

José Luis Nieva Escandón (1991)

Ana Rosa Viguera Rincón (1992)

José Castresana Villamor (1992)

Helena Ostolaza Echabe (1992)

Sonia Bañuelos Rodríguez (1995)

Mª Asunción Requero Zabala (1995)

Gorka Basañez Asua (1996)

Fernando Moro (1996)

Ana Soloaga Villoch (1997)

Susana Rivas Cacho (1997)

Izaskun Echabe Pérez (1997)

Francisca Pereira Rios (1997)

9. PhD Thesis at IBF

82

Mª Begoña Ruiz-Argüello (1998)Mª Begoña Ruiz-Argüello (1998)

José Manuel Martínez Caaveiro (1999)

Mª Pilar Veiga Alameda (1999)

Ana V. Villar Ramos (2000)

Tatiana Suárez Cortés (2000)

Asier Sáez Cirión (2001)

Aitor Hierro Ayuela ( 2002)

Aitziber López Cortajarena (2002)

Aitziber Agirre Ruiz de Arkaute (2003)

Asier Galán Cousillas (2003)

Ion Gutiérrez Aguirre (2003)

Itsaso Hormaeche Berciano (2003)

Begoña Sot Sanz (2003)

Ibon Iloro Manzano (2004)

Xabier Coto Revuelta (2004)

Jesús Sot Sanz (2005)

Ruth Montes Burgos (2005)

Vanesa Fernández Sáiz (2006)

Isbaal Ramos Hernández (2006)

Maier Lorizate Nogales (2006)

Francesc-Xabier Contreras Gómez (2006)

Mª Begoña Ruiz-Argüello (1998)Mª Begoña Ruiz-Argüello (1998)

José Manuel Martínez Caaveiro (1999)

Mª Pilar Veiga Alameda (1999)

Ana V. Villar Ramos (2000)

Tatiana Suárez Cortés (2000)

Asier Sáez Cirión (2001)

Aitor Hierro Ayuela ( 2002)

Aitziber López Cortajarena (2002)

Aitziber Agirre Ruiz de Arkaute (2003)

Asier Galán Cousillas (2003)

Ion Gutiérrez Aguirre (2003)

Itsaso Hormaeche Berciano (2003)

Begoña Sot Sanz (2003)

Ibon Iloro Manzano (2004)

Xabier Coto Revuelta (2004)

Jesús Sot Sanz (2005)

Ruth Montes Burgos (2005)

Vanesa Fernández Sáiz (2006)

Isbaal Ramos Hernández (2006)

Maier Lorizate Nogales (2006)

Francesc-Xabier Contreras Gómez (2006)Francesc-Xabier Contreras Gómez (2006)

Silvia Sánchez Martínez (2007)

Lissete Sánchez Magraner (2007)

Marcos García Pacios (2007)

Oihana Terrones Urio (2007)

Aintzane Cabo Bilbao (2008)

José Ángel Fernández Higuero (2008)

Paloma Aivar Mateo (2008)

Sergio Pérez Acebrón (2008)

Nerea Huarte Arrayago (2008)

Aitor Etxebarria Gallego (2009)

David López Jiménez (2009)

Patricia Urbina Fernández (2009)

Jon Agirre Hernández (2009)

Geraxane Gómez Bilbao (2009)

Ariel E. Mechaly García (2009)

Maitane Ibarguren Aizpitarte (2009)

Igor de la Arada Etxebarria (2009)

Ana Julia Vecino Ortega (2009)

Jon Busto Vega (2009)

Igor Arregi Vado (2010)

Juan Camilo Gómez Posada (2010)

Jon Busto Vega (2009)

Igor Arregi Vado (2010)

Juan Camilo Gómez Posada (2010)

84

Silvia Sánchez Martínez (2007)

Lissete Sánchez Magraner (2007)

Marcos García Pacios (2007)

Oihana Terrones Urio (2007)

Aintzane Cabo Bilbao (2008)

José Ángel Fernández Higuero (2008)

Paloma Aivar Mateo (2008)

Sergio Pérez Acebrón (2008)

Nerea Huarte Arrayago (2008)

Aitor Etxebarria Gallego (2009)

David López Jiménez (2009)

Patricia Urbina Fernández (2009)

Jon Agirre Hernández (2009)

Geraxane Gómez Bilbao (2009)

Ariel E. Mechaly García (2009)

Maitane Ibarguren Aizpitarte (2009)

Igor de la Arada Etxebarria (2009)

Ana Julia Vecino Ortega (2009)

Jon Busto Vega (2009)

Igor Arregi Vado (2010)

Juan Camilo Gómez Posada (2010)

Urko del Castillo Rojo (2010)

Alessandro Alaimo Campi (2010)

Alain Ibañez de Opakua López de Abetxuko (2011)

Rubén Maeso Gallego (2011)

Judit Perales Calvo (2012)

Begoña Ugarte Uribe (2012)

Beatriz Apellaniz Unzalu (2012)

Koldobika Morante Sagasti (2012)

Juncal Fernández Orth (2012)

Jorge Falces Ramos (2012)

Iván Bermejo Luhía (2012)

Ianire Martín Sánchez (2013)

Kepa Belloso Uribe (2013)

Simon Paul Jeremie Poly (2013)

Ane Landajuela Larma (2013)

Olatz Landeta Díaz (2013)

Itziar Martínez Domínguez (2013)

Noemí Jiménez Rojo (2013)

Nagore Andraka Rueda (2014)

Garbiñe Celaya Garavilla (2014)

Sandra Águila Arcos (2014)

Garbiñe Celaya Garavilla (2014)

Sandra Águila Arcos (2014)

Noelia Fernández Rivero (2014)

Saioa Urresti San Vicente (2014)

Aitziber Araujo Pasarín (2014)

Marco Manni Marchei (2014)

Marta Gutiérrez Lete (2014)

Aritz García Arribas (2014)

Araitz Alberdi González (2015)

Alejandra Aguado Martínez (2015)

Eva Rodríguez Hortelano (2015)

Itsasne Bustillo Zabalbeitia (2015)

Gloria de las Heras Martínez (2015)

Ane Rodrigo Unzueta (2015)

Rubén Sánchez Eugenia (2015)

Ganeko Bernardo Seisdedos (2015)

Javier Hervás Hidalgo (2016)

Olatz Garaiyurrebaso Rodríguez (2016)

Edurne Rujas Díaz (2016)

Saioa Urresti San Vicente (2014)

Alejandra Aguado Martínez (2015)

Eva Rodríguez Hortelano (2015)

Itsasne Bustillo Zabalbeitia (2015)

Gloria de las Heras Martínez (2015)

Ganeko Bernardo Seisdedos (2015)

Olatz Garaiyurrebaso Rodríguez (2016)

86

82

10. IBF in numbers

Research groups

Men-female

Group leaders and staff scientists

Postdoctoral

PhD students

Technical support

Administration

Other students and visiting scientists

TOTAL

IBF Staff

2015 2016

89

Technical support

Administration

101

49%-51%

30

38

33

15

5

37

158

81

48%-52%

28

29

24

15

5

47

148

National Funding Entities

International Funding Entities

Excellence programs

Contracts with private companies

Other founding sources

TOTAL

Research Funding

2015 2016

Other founding sources

47

680,721 €

170,800 €

713.122 €

81,828 €

913,723 €

921,156 €

91,460 €

721.629 €

2,277 €

583,8

2.320,377 €

15

96

583,855 €

2.320,377 €2.560,194 €

Number publications

Q1 percentage

h-index

Number of citations

Publications

2015 2016

Number publications

%

67

69 %

52

9.276

%

48

70%

56

11.769

11. Funding

92

In 2015 and 2016, the Instituto Biofisika received funding from the

following institutions:

University of the Basque Country (UPV/EHU)

Spanish National Research Council (CSIC)

Spanish Ministry of Economy, Industry and Competitiveness

Basque Government (Department of Education and Department of

Economic Development and Infrastructure)

Regional Government of Biscay

Bizkaia Biophysics Foundation

The Instituto Biofisika wishes to thank to all of these sponsors for their

generous funding and ongoing support.

8989

SCIENTIFIC REPORT

INSTITUTO BIOFISIKA

2015-2016