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Immune Response

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How does the mecanism

of foreign configuration can cause bothnon specific and specific immune

response?

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Complement

• Complement is a group of protease in a serum

which complement serum’s activity in bacteria

or cell lysis

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CRP (C-reactive Protein)

• An acute phase protein; group of protein

which is increasing in blood when acute

infection happens

• CRP as opsonin to actived classic pathway of

complement

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Cytokine

• Cytokine is group of peptide which is

produced by immunocompetent cell and plays

a role in reducing or increasing immune

system

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Cellular Immune System

• Phagocytes

• NK Cell

•

Lymphocytes

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Phagocytes

• Cells which attract (using chemotaxis),

attached to, swallow, and digest foreign

materials

• Include macrophage

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NK Cell

• NK cell is granular lymphocyte which canrecognize infected surface glycoprotein cell andkill that cell.

•It’s  circulating in the blood and lymph to lysecancer cells and virus-infected cells.

• The number of NK cells around 5-5% oflymphocyte in blood and 45% of lymphocyte in

tissues.• These cells have function in nonspecific immunity

against viruses and tumor cells.

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Lymphocytes

• Lymphocytes are cellular components of the

immune system that is specific to the antigen

through receptor structures on the surface of

immunocompetent cells.

• Lymphocytes are divided into two, namely T

and B lymphocytes

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Limfosit T

• it differentiates from thymus gland

• besides as immunocompetent cells, T

lymphocytes also play a role as a regulator in

the bone marrow, whether the body will

respond in humoral or cellular.

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Limfosit B

• It differentiates in Bursa Fabricius for aves and

in gut associated lymphoid tissue (GALT) for

other vertebrates.

• B lymphocytes play a role in humoral immune

system therefore they will be able to

differentiate into plasma cells which can

generate specific antibodies.

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Antibody/Immunoglobulin

• group of glycoprotein which is produced by

plasma cells in response to certain foreign

configuration

• It can bind to the antigen, complement, or

receptors on the surface of

immunocompetent cells

• Antibody can increase the effectivity of

antigen elimination

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How non specific immuneresponse become specific

immune response?

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•Nonspecific immunity acts as first line ofdefense against infectious agent, which

pathogen will be destroyed before it

proliferates and causing infection.• If this defense doesn’t  work well, specific

immune system will be activated.

•

Healing through a specific immune responsewill leave specific immunological memory so

that subsequent infection with the same

infectious agent will not cause disease

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Respon Imun

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Trims