dinesh dissertation presentation

8/16/2019 Dinesh Dissertation Presentation

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Presentation submitted

by

Dinesh Rathva

CUG/2014/1059

Under the guidance o

Pro! "an #ingh

Dean

#choo$ o chemica$ #ciences

Centra$ University o Gu%arat& Gandhinagar

'(('C) *( #UR(+C)+,)# *, P+R)-)-*,

C*'((-C-',) *( -*D-,' -, ).* P+#'

#*',) ##)'"



Contents of my Dissertation

Prob$em )heme

-ntroduction

*b%ective

"ateria$ and methods

Resu$t and Discussion

Conc$usion

(uture Pros3ect



Prob$em )heme

•

-odine deiciency causes goiter

• Radioactive iodine stabi$ied by stabi$ier& hich can strong$y aect the target

organ in the body

• -n meta$$urgy& the 3artition coeicient is an im3ortant actor in determining ho

dierent im3urities are distributed beteen mo$ten and so$idiied meta$

• + drug6s 3artition coeicient #trong$y aects7

the drug intended target

its eect once it reaches its target

time 3eriod o its activity



-ntroduction

• Partition coeicient 8 ratio o concentrations o a com3ound in a miture o to

immiscib$e 3hases at e:ui$ibrium $i;e a:ueous and organic

• Partition coeicient o substance can be deined as7 <3conc! * a:! Phase / Conc!

* organic 3hase

• Partition coeicients are useu$ in estimating the distribution coeicient o drugs

ithin the body

• -mmiscib$e so$vents 3hases have been used as a uni:ue mode$ or study o 3artition

coeicient

• )he mutua$ miscibi$ity is obtained by adding the suractants to a set o immiscib$e

so$vents that cause hydro3hi$ic and hydro3hobic interactions

• )he suractant decrease the chemica$ 3otentia$ o individua$ so$vent due to

interaction as 3er $i:uid8$i:uid interacia$ mode$ o so$vents

•



*b%ectives o my study

• Determination o 3artition coeicient o iodine conc! in a:ueous /organic 3hase

• Determination o concentration iodine absorbed in a:! suractants ith organic 3hase

• Determination o 3artition entro3y and Gibbs ree energy by using =o$tmann

distribution $a



Materials: -odine>-2? & CC$4& )een 20& )een 40 &)een @0& )een A0& #tarch >indicator?& #odium

thiosu$3hate >,a2#2*B!52*? and "i$$i3ore ater

Method:

• 0!04" iodine as 3re3ared in CC$4

• 0!005" non8ionic suractants ere se3arate$y 3re3ared in 50m ater7)een820& )een840& )een8@0

and )een8A0

• )he chromatogra3hic se3aration method as used or determine 3artition coeicient o -2 in ater and

a:! #uractants!

• (irst$y& =y ta;ing 20m o -2 so$ution in se3arating unne$ and then 40m ater added in se3arating

unne$ and sha;e and ;e3t or e:ui$ibrium! +ter that to 3hase overcome >a:ueous 3hase and organic

3hase?& se3arate them and titration o both 3hase ere carried out ith 0!01" sodium thiosu$3hate by

using starch as an indicator

• +nd simi$ar method ere used or a:! suractants to determine P!C!

Characterization methods

Dynamic $ight #cattering to determine dis3ersity o iodine in a:! Phases

U8isib$e #3ectrosco3y )o determine absorbance o -odine in res3ective +:! Phases

"ateria$s "ethod



Separation method for Kp determination

After Shaking

Aq. Phase

Org. Phase

Separation ofphases

Take Aq. Layer from each ask and titrate ith sodi!mthios!" hate



Distribution Pattern o -odine in +:! Phases

I2 in

water

I2 inCCl4

I2 inTween 20

I2 inTween 40

Conti####

Resu$ts Discussion



Conti####

I2 inTween 60

I2 inTween 80



+bsorbance o -2 in *rganic Phase

200 B00 400 500 @00 E00 A00

0

0!5

1

1!5

2

2!5

B

B!5

4

4!5

I2 in CCL4

.ave$ength >nm?

+bsorbance



Partition coeicient o -odine<3F >Conc! o -2 in a:! Phase / Conc! o -2 in *rg! Phase?

$irstorder

%.%%%% %.%%&% %.%%'% %.%%(% %.%%)% %.%%*% %.%%+% %.%%,% %.%%-% %.%%% %.%&%%

%.%%

%.%*

%.&%

%.&*

%.'%

%.'*

%.(%

%.(*

f/01 2 ((.0 3 %.%&

45 2 &

Concentration of Aq. Phases

Kp



(ree energy o iodine in +:! Phases

Aq. Phases Conc.of aq. Phase 67

8ater %.%%& (,,).)

T3'% %.%%' (%'-.,)

T3)% %.%%( ',&.%)

T3+% %.%%( '*'.')

T3-% %.%% &'+.&'

$irst order

%.%%% %.%%& %.%%' %.%%( %.%%) %.%%* %.%%+ %.%%, %.%%- %.%% %.%&%

%

*%%

&%%%

&*%%

'%%%

'*%%

(%%%

(*%%

)%%%

45 2 %.(

Concentration of Aq. Phase

Free energy !"#ol$



Conc$usion

• )een 20 to )een A0 -odine goes rom CC$4 to 2*

• Dis3ersion o iodine changed ith varying )eens series rom )820 to

)8A0!

• +bsorbance o -odine observed in U range >2008400nm? not in isib$e

range >400 A00 nm?!

• (ree energy o iodine in a:! Phase decrease ith increasing

concentration o iodine!



(uture Pros3ect

• +t - suractant gets de3osit

• -odine so$ubi$ity increasing in a:ueous 3hase

• #uractant contro$ on -odine distribution

• -n 3$ace CC$4& D"#*& D"'& 'ther and benene ou$d be

used



+c;no$edgements

%y &'per(isor Prof. %an &ingh) *ean &C&) C+,

*r. P.C. !ha) *r. *hanan-ay %onal) *r. &#ritile/ha era) *r. 1.a-' Cha'han

%r. harat . atho

Friens

Fa#ily #e#3ers



Thank 9o!

dinesh dissertation presentation

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