er stress pathway · 2018-11-12 · apoptosis atf6 (p50) atf6 (p90) ire1 perk ire1 xbp1 mrna...
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Apoptosis
ATF6(p50)
ATF6(p90)
PERKIRE1 IRE1
XBP1 mRNA splicing
ATF6(p50)
Mitochondria
Endoplasmicreticulum
Golgi apparatus
Cytochrome C
UPR genes (GRP78, PDI, GRP94, etc)
Secretion
ROSProteasomal degradation
ERSEs
Unfolded protein
Nucleus
ATF6 (p90)
Pro-caspase-12
Caspase12Caspase 3
Bcl-2 JNK
ATF4
PP1
GADD34XBP1s
EDEMDerlin
elF-2α
CHOP
ATF4 XBP1s
ASK1
PPP P P
Kinase
Phosphatase
Transcriptionfactor
Ligand
Kinase
Key
Translation
ER stress pathway
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