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De Nederlandse Hersenbank voor Psychiatrie:
Oog voor details
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ASS: tekortkoming of talent
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Wat is er dan anders?
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Postmortem: de missing link?
MRI DNA
Dier NHB-Psy
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Donor Onderzoeker
De Nederlandse Hersenbank
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N = 4039(26 juli 2016)
CO = controleFTLD/Tau = frontotemporale dementieMS = multiple sclerosePD = ziekte van ParkinsonPSP = progressieve supranucleaire paralysePsych = psychiatrische aandoeningAD = ziekte van AlzheimerRest = overige ziektebeeldenDem = overige dementieën
Registraties
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1 uitsnijdprotocol
1. Snelle'obduc- e'volgens'protocol
2. Samenva7 ng'medische'gegevens
3. Gespecialiseerde'neuropathologische'diagnose
2. Obductie, diagnostiek en opslag
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Binnen ziekten meer homogenere subgroepen onderzoekenTussen ziekten overlappende symptomen onderzoeken
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Via iPSCs(stamcellen)
Microglia Astrocyten Neuronen
NHB-Psy: cellen waar we mee werken
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Het immuunsysteem in ASS
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Microglia fenotypes
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NHB-Psy maakt meer mogelijk
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Stress gerelateerde genexpressie:verschil depressie - suïcide
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Suïcidaliteit:Meer suïcidale gedachten bij personen met stoornis van Asperger
Lancet Psychiatry, 2014
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Doel NHB-Psy: boost onderzoek door meer breinen
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Nieuwe inzichten Beter begrip van de ziekte
Verbeteren bestaande therapieënOntwikkelen van nieuwe therapieën
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