Download - Neoplasia VI
Neoplasia VINeoplasia VI DR OSAMA I NASSIF FRCPCDR OSAMA I NASSIF FRCPC
CONSULTANT & ASSOCIATE CONSULTANT & ASSOCIATE PROFESSORPROFESSOR
DEPARTMENT OF PATHOLOGY, KAUHDEPARTMENT OF PATHOLOGY, KAUH
Neoplasia VI
DR OSAMA I NASSIF MD,FRCPCDR OSAMA I NASSIF MD,FRCPC
CONSULTANT & ASSOCIATE CONSULTANT & ASSOCIATE PROFESSORPROFESSOR
DEPARTMENT OF PATHOLOGYDEPARTMENT OF PATHOLOGY
KAUHKAUH
Neoplasia VINeoplasia VI DR OSAMA I NASSIF FRCPCDR OSAMA I NASSIF FRCPC
CONSULTANT & ASSOCIATE CONSULTANT & ASSOCIATE PROFESSORPROFESSOR
DEPARTMENT OF PATHOLOGY, KAUHDEPARTMENT OF PATHOLOGY, KAUH
Etiology of cancer. Chemical carcinogens.
Radiation carcinogenesis.
Viral oncogenesis.
Neoplasia VINeoplasia VI DR OSAMA I NASSIF FRCPCDR OSAMA I NASSIF FRCPC
CONSULTANT & ASSOCIATE CONSULTANT & ASSOCIATE PROFESSORPROFESSOR
DEPARTMENT OF PATHOLOGY, KAUHDEPARTMENT OF PATHOLOGY, KAUH
Biology of tumor growth.
• Kinetics of tumor cell growth.
• Tumor angiogenesis.
• Tumor progression and heterogeneity.
• Tumor invasion and spread.
Neoplasia VINeoplasia VI DR OSAMA I NASSIF FRCPCDR OSAMA I NASSIF FRCPC
CONSULTANT & ASSOCIATE CONSULTANT & ASSOCIATE PROFESSORPROFESSOR
DEPARTMENT OF PATHOLOGY, KAUHDEPARTMENT OF PATHOLOGY, KAUH
Kinetics Of Tumor Cell Growth
Doubling time : equal or more than that of normal cells.
Growth fraction : cells in replicative pool , rarely >20%.
Production vz loss :
Neoplasia VINeoplasia VI DR OSAMA I NASSIF FRCPCDR OSAMA I NASSIF FRCPC
CONSULTANT & ASSOCIATE CONSULTANT & ASSOCIATE PROFESSORPROFESSOR
DEPARTMENT OF PATHOLOGY, KAUHDEPARTMENT OF PATHOLOGY, KAUH
Tumor Angiogenesis
Tumor-associated angiogenic factors : -bFGF , VEGF……etc. Macrophage derived growth factors: -TNF-α. Weak angiogenic inhibitors: -Angiostatin , thrombospondin ( p53
upregulated) .
Neoplasia VINeoplasia VI DR OSAMA I NASSIF FRCPCDR OSAMA I NASSIF FRCPC
CONSULTANT & ASSOCIATE CONSULTANT & ASSOCIATE PROFESSORPROFESSOR
DEPARTMENT OF PATHOLOGY, KAUHDEPARTMENT OF PATHOLOGY, KAUH
Kinetics Of Tumor Cell Growth
Clinical implications: 1- cancer therapey: Targeting cycling cells.
Effect of radiation & debulking.
2- latent period of tumors :
Months to years.
Neoplasia VINeoplasia VI DR OSAMA I NASSIF FRCPCDR OSAMA I NASSIF FRCPC
CONSULTANT & ASSOCIATE CONSULTANT & ASSOCIATE PROFESSORPROFESSOR
DEPARTMENT OF PATHOLOGY, KAUHDEPARTMENT OF PATHOLOGY, KAUH
Tumor Progression and Heterogeneity.
Neoplasia VINeoplasia VI DR OSAMA I NASSIF FRCPCDR OSAMA I NASSIF FRCPC
CONSULTANT & ASSOCIATE CONSULTANT & ASSOCIATE PROFESSORPROFESSOR
DEPARTMENT OF PATHOLOGY, KAUHDEPARTMENT OF PATHOLOGY, KAUH
Tumor Invasion and Spread.
Methods of spread : - Direct. -Through blood vessels. -Through lymph
vessels.
Neoplasia VINeoplasia VI DR OSAMA I NASSIF FRCPCDR OSAMA I NASSIF FRCPC
CONSULTANT & ASSOCIATE CONSULTANT & ASSOCIATE PROFESSORPROFESSOR
DEPARTMENT OF PATHOLOGY, KAUHDEPARTMENT OF PATHOLOGY, KAUH
Neoplasia VINeoplasia VI DR OSAMA I NASSIF FRCPCDR OSAMA I NASSIF FRCPC
CONSULTANT & ASSOCIATE CONSULTANT & ASSOCIATE PROFESSORPROFESSOR
DEPARTMENT OF PATHOLOGY, KAUHDEPARTMENT OF PATHOLOGY, KAUH
Neoplasia VINeoplasia VI DR OSAMA I NASSIF FRCPCDR OSAMA I NASSIF FRCPC
CONSULTANT & ASSOCIATE CONSULTANT & ASSOCIATE PROFESSORPROFESSOR
DEPARTMENT OF PATHOLOGY, KAUHDEPARTMENT OF PATHOLOGY, KAUH
Neoplasia VINeoplasia VI DR OSAMA I NASSIF FRCPCDR OSAMA I NASSIF FRCPC
CONSULTANT & ASSOCIATE CONSULTANT & ASSOCIATE PROFESSORPROFESSOR
DEPARTMENT OF PATHOLOGY, KAUHDEPARTMENT OF PATHOLOGY, KAUH
Neoplasia VINeoplasia VI DR OSAMA I NASSIF FRCPCDR OSAMA I NASSIF FRCPC
CONSULTANT & ASSOCIATE CONSULTANT & ASSOCIATE PROFESSORPROFESSOR
DEPARTMENT OF PATHOLOGY, KAUHDEPARTMENT OF PATHOLOGY, KAUH
Neoplasia VINeoplasia VI DR OSAMA I NASSIF FRCPCDR OSAMA I NASSIF FRCPC
CONSULTANT & ASSOCIATE CONSULTANT & ASSOCIATE PROFESSORPROFESSOR
DEPARTMENT OF PATHOLOGY, KAUHDEPARTMENT OF PATHOLOGY, KAUH
Neoplasia VINeoplasia VI DR OSAMA I NASSIF FRCPCDR OSAMA I NASSIF FRCPC
CONSULTANT & ASSOCIATE CONSULTANT & ASSOCIATE PROFESSORPROFESSOR
DEPARTMENT OF PATHOLOGY, KAUHDEPARTMENT OF PATHOLOGY, KAUH
Neoplasia VINeoplasia VI DR OSAMA I NASSIF FRCPCDR OSAMA I NASSIF FRCPC
CONSULTANT & ASSOCIATE CONSULTANT & ASSOCIATE PROFESSORPROFESSOR
DEPARTMENT OF PATHOLOGY, KAUHDEPARTMENT OF PATHOLOGY, KAUH
Neoplasia VINeoplasia VI DR OSAMA I NASSIF FRCPCDR OSAMA I NASSIF FRCPC
CONSULTANT & ASSOCIATE CONSULTANT & ASSOCIATE PROFESSORPROFESSOR
DEPARTMENT OF PATHOLOGY, KAUHDEPARTMENT OF PATHOLOGY, KAUH
Neoplasia VINeoplasia VI DR OSAMA I NASSIF FRCPCDR OSAMA I NASSIF FRCPC
CONSULTANT & ASSOCIATE CONSULTANT & ASSOCIATE PROFESSORPROFESSOR
DEPARTMENT OF PATHOLOGY, KAUHDEPARTMENT OF PATHOLOGY, KAUH
Neoplasia VINeoplasia VI DR OSAMA I NASSIF FRCPCDR OSAMA I NASSIF FRCPC
CONSULTANT & ASSOCIATE CONSULTANT & ASSOCIATE PROFESSORPROFESSOR
DEPARTMENT OF PATHOLOGY, KAUHDEPARTMENT OF PATHOLOGY, KAUH
Neoplasia VINeoplasia VI DR OSAMA I NASSIF FRCPCDR OSAMA I NASSIF FRCPC
CONSULTANT & ASSOCIATE CONSULTANT & ASSOCIATE PROFESSORPROFESSOR
DEPARTMENT OF PATHOLOGY, KAUHDEPARTMENT OF PATHOLOGY, KAUH
Neoplasia VINeoplasia VI DR OSAMA I NASSIF FRCPCDR OSAMA I NASSIF FRCPC
CONSULTANT & ASSOCIATE CONSULTANT & ASSOCIATE PROFESSORPROFESSOR
DEPARTMENT OF PATHOLOGY, KAUHDEPARTMENT OF PATHOLOGY, KAUH
Neoplasia VINeoplasia VI DR OSAMA I NASSIF FRCPCDR OSAMA I NASSIF FRCPC
CONSULTANT & ASSOCIATE CONSULTANT & ASSOCIATE PROFESSORPROFESSOR
DEPARTMENT OF PATHOLOGY, KAUHDEPARTMENT OF PATHOLOGY, KAUH
Neoplasia VINeoplasia VI DR OSAMA I NASSIF FRCPCDR OSAMA I NASSIF FRCPC
CONSULTANT & ASSOCIATE CONSULTANT & ASSOCIATE PROFESSORPROFESSOR
DEPARTMENT OF PATHOLOGY, KAUHDEPARTMENT OF PATHOLOGY, KAUH
Neoplasia VINeoplasia VI DR OSAMA I NASSIF FRCPCDR OSAMA I NASSIF FRCPC
CONSULTANT & ASSOCIATE CONSULTANT & ASSOCIATE PROFESSORPROFESSOR
DEPARTMENT OF PATHOLOGY, KAUHDEPARTMENT OF PATHOLOGY, KAUH
Neoplasia VINeoplasia VI DR OSAMA I NASSIF FRCPCDR OSAMA I NASSIF FRCPC
CONSULTANT & ASSOCIATE CONSULTANT & ASSOCIATE PROFESSORPROFESSOR
DEPARTMENT OF PATHOLOGY, KAUHDEPARTMENT OF PATHOLOGY, KAUHEtiology of Cancer.
Chemical carcinogens.
Radiation carcinogenesis.
Viral oncogenesis.
Neoplasia VINeoplasia VI DR OSAMA I NASSIF FRCPCDR OSAMA I NASSIF FRCPC
CONSULTANT & ASSOCIATE CONSULTANT & ASSOCIATE PROFESSORPROFESSOR
DEPARTMENT OF PATHOLOGY, KAUHDEPARTMENT OF PATHOLOGY, KAUH
Chemical Carcinogens.
Neoplasia VINeoplasia VI DR OSAMA I NASSIF FRCPCDR OSAMA I NASSIF FRCPC
CONSULTANT & ASSOCIATE CONSULTANT & ASSOCIATE PROFESSORPROFESSOR
DEPARTMENT OF PATHOLOGY, KAUHDEPARTMENT OF PATHOLOGY, KAUHChemical Carcinogens.
Neoplasia VINeoplasia VI DR OSAMA I NASSIF FRCPCDR OSAMA I NASSIF FRCPC
CONSULTANT & ASSOCIATE CONSULTANT & ASSOCIATE PROFESSORPROFESSOR
DEPARTMENT OF PATHOLOGY, KAUHDEPARTMENT OF PATHOLOGY, KAUHChemical CarcinogensChemical Carcinogens
Neoplasia VINeoplasia VI DR OSAMA I NASSIF FRCPCDR OSAMA I NASSIF FRCPC
CONSULTANT & ASSOCIATE CONSULTANT & ASSOCIATE PROFESSORPROFESSOR
DEPARTMENT OF PATHOLOGY, KAUHDEPARTMENT OF PATHOLOGY, KAUHChemical Carcinogens
Neoplasia VINeoplasia VI DR OSAMA I NASSIF FRCPCDR OSAMA I NASSIF FRCPC
CONSULTANT & ASSOCIATE CONSULTANT & ASSOCIATE PROFESSORPROFESSOR
DEPARTMENT OF PATHOLOGY, KAUHDEPARTMENT OF PATHOLOGY, KAUHChemical Carcinogens
Neoplasia VINeoplasia VI DR OSAMA I NASSIF FRCPCDR OSAMA I NASSIF FRCPC
CONSULTANT & ASSOCIATE CONSULTANT & ASSOCIATE PROFESSORPROFESSOR
DEPARTMENT OF PATHOLOGY, KAUHDEPARTMENT OF PATHOLOGY, KAUH
Chemical Carcinogens
Neoplasia VINeoplasia VI DR OSAMA I NASSIF FRCPCDR OSAMA I NASSIF FRCPC
CONSULTANT & ASSOCIATE CONSULTANT & ASSOCIATE PROFESSORPROFESSOR
DEPARTMENT OF PATHOLOGY, KAUHDEPARTMENT OF PATHOLOGY, KAUH
Chemical Carcinogens
Neoplasia VINeoplasia VI DR OSAMA I NASSIF FRCPCDR OSAMA I NASSIF FRCPC
CONSULTANT & ASSOCIATE CONSULTANT & ASSOCIATE PROFESSORPROFESSOR
DEPARTMENT OF PATHOLOGY, KAUHDEPARTMENT OF PATHOLOGY, KAUH
Neoplasia VINeoplasia VI DR OSAMA I NASSIF FRCPCDR OSAMA I NASSIF FRCPC
CONSULTANT & ASSOCIATE CONSULTANT & ASSOCIATE PROFESSORPROFESSOR
DEPARTMENT OF PATHOLOGY, KAUHDEPARTMENT OF PATHOLOGY, KAUH
Chemotherapy Induced Malignancies