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Microglia
Astrocitos
Monocitos
Células endoteliales
Leucocitos del LCR
Producción de citocinas y quimiocinas
inflamatorias.
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Aparecen TNF e IL1 al cabo de 1
a 2h
Aumento de proteínas y
leucocitos en LCR
Leucocitos producen citoquinas
(quimiotaxis)
Aparecen otras citoquinas
proinflamatorias
La bacteremia y las citoquinas inflamatorias
• Aminoacid
os
excitadores
• O y N
reactivo
Muerte de
células
cerebrales
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Aumentan permeabilidad
de la BHC
Aumento de IL1 y TNF en
LCR
Exudado subaranoicdeo
Edema vasogenico
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Obstrucción del flujo del
LCR
Disminucion de la capacidad reabsortiva de
las granulaciones aracnoideas
Hidrocefalia obstructiva
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Incremento flujo sanguíneo cerebral
Disminución del FSC con la perdida de la autorregulación cerebrovascular
Angostamiento de las arterias de la base del encéfalo (vasculitis)
Isquemia, infarto, trombosis arteria cerebral media,
trombosis senos venosos y tromboflebitis venas de la corteza cerebral
Edema intersticial, vasogeno y citotoxico
Aumento
presión
intracraneal
= COMA