-
7/23/2019 EVALUACIN DEL EFECTO DE UN PROBITICO NATIVO ELABORADOEN BASE A Lactobacillus acidophilus y Bacillus su
1/105
CWGSCJF ^HJKTGEKGF DCJ CMPGKTH
DC^FPTFACETH DC GKCEGKFW DC JF YKDF
GFPPCPF DC KEOCEKCPKF CE GKCEGKFW FOPH^CGSFPKFW
WFETH DHAKEOH DC JHW TWGBKJFW
TCAF
CYFJSFGKE DCJ CICGTH DC SE ^PH@KTKGH EFTKYH CJF@HPFDH
CE @FWC FJfgth`fgkjjus fgkdhpbkjus y@fgkjjus su`tkjks CE ^HJJHW @PHKJCP
PHWW!7>2 CE WFETH DHAKEOH DC JHW TWGBKJFW%
FSTHPCW
MSFE GFPJHW FOSFYKJ CEPKVSC]
WFETKFOH FDPKFE CEPKVSC] OSFEOF
KEIHPAC TGEKGH DCJ ^PH[CGTH DC KEYCWTKOFGKE
0>66
-
7/23/2019 EVALUACIN DEL EFECTO DE UN PROBITICO NATIVO ELABORADOEN BASE A Lactobacillus acidophilus y Bacillus su
2/105
KK
CWGSCJF HJKTGEKGF DCJ CMPGKTH
DC^FPTFACETH DC GKCEGKFW DC JF YKDF
GFPPCPF DC KEOCEKCPKF CE GKCEGKFW FOPH^CGSFPKFW
WFETH DHAKEOH DC JHW TWGBKJFW
CYFJSFGKE DCJ CICGTH DC SE ^PH@KTKGH EFTKYH CJF@HPFDH
CE @FWC FJfgth`fgkjjus fgkdhpbkjus y@fgkjjus su`tkjks CE ^HJJHW @PHKJCP
PHWW!7>2 CE WFETH DHAKEOH DC JHW TWGBKJFW%
FSTHPCW
MSFE GFPJHW FOSFYKJ CEPKVSC]
WFETKFOH FDPKFE CEPKVSC] OSFEOF
KEIHPAC TGEKGH DCJ ^PH[CGTH DC KEYCWTKOFGKE ^PCWCETFDH
GHAH PCVSKWKTH ^FPGKFJ ^FPF H^TFP FJ TKTSJH DC KEOCEKCPH
FOPH^CGSFPKH
WFETH DHAKEOH ! CGSFDHP
0>66
-
7/23/2019 EVALUACIN DEL EFECTO DE UN PROBITICO NATIVO ELABORADOEN BASE A Lactobacillus acidophilus y Bacillus su
3/105
KKK
CYFJSFGKE DCJ CICGTH DC SE ^PH@KTKGH EFTKYH CJF@HPFDH
CE @FWC FJfgth`fgkjjus fgkdhpbkjus y@fgkjjus su`tkjks CE ^HJJHW @PHKJCP
PHWW!7>2 CE WFETH DHAKEOH DC JHW TWGBKJFW%
MSFE GFPJHW FOSFYKJ CEPKVSC]
WFETKFOH FDPKFE CEPKVSC] OSFEOF
PCYKWFDH [ F^PH@FDH
KEO% YKGCETC FE]SJCW
DKPCGTHP DC GFPPCPF
GFPPCPF DC KEOCEKCPKF CE GKCEGKFW FOPH^CGSFPKFW
%%% %%%
@JOH% ECWTHP WFJTHW KEO% AWg% OSWTFYH ESC]
DKPCGTHP GHDKPCGTHP
%KEO% YKEKGKH SDF[
@KHACTPKWTF
GCPTKIKGH VSC CWTC TPF@FMH ISC ^PCWCETFDH CE HPKOKEFJ
"CE ACDKH AFOETKGH+ C KA^PCWH CE DHW CMCA^JFPCW%
SEKDFD DC FDAKWKE [ PCOKWTPH
-
7/23/2019 EVALUACIN DEL EFECTO DE UN PROBITICO NATIVO ELABORADOEN BASE A Lactobacillus acidophilus y Bacillus su
4/105
KY
CYFJSFGKE DCJ CICGTH DC SE ^PH@KTKGH EFTKYH CJF@HPFDH
CE @FWC FJfgth`fgkjjus fgkdhpbkjus y@fgkjjus su`tkjks CE ^HJJHW @PHKJCP
PHWW!7>2 CE WFETH DHAKEOH DC JHW TWGBKJFW%
MSFE GFPJHW FOSFYKJ CEPKVSC]
WFETKFOH FDPKFE CEPKVSC] OSFEOF
F^PH@FDH ^HP JHW WCHPCW AKCA@PHW DCJ TPK@SEFJ DC
GFJKIKGFGKE DCJ KEIHPAC TGEKGH
GFJKIKGFGKE ICGBF
@JOH% ECWTHP WFJTHW
DKPCGTHP
KEO% AWg% OSWTFYH ESC]
GHDKPCGTHP
GCPTKIKGH VSC CWTFW GFJKIKGFGKHECW ISCPHE
^PCWCETFDFW CE CWTF WCGPCTFPKF
SEKDFD DC FDAKWKE [ PCOKWTPH
-
7/23/2019 EVALUACIN DEL EFECTO DE UN PROBITICO NATIVO ELABORADOEN BASE A Lactobacillus acidophilus y Bacillus su
5/105
Y
D C D K G F T H P K F
Fj gujakefr uef kaphrtfetc ctfpf dc ak vkdf* dcdkgh ak csiucrzh y dcdkgfgke*
rcijcmfdh ce cstf tcsks f=
Dkhs phr dfrac jf vkdf c kjuakefrac df f df ce fqucjjhs ahaceths dkigkjcs
skcedh ak ouf%
F aks qucrkdhs pfdrcs Gcjsh y Gfrace* phr `rkedfrac thdh su fphyh%
F aks bcrafefs Ksf`cj y Feojkgf* qukcecs iucrhe pkjfr kaphrtfetc durfetc
thdh cstc tkcaph* dhedc ghapfrtkahs augbfs vkvcegkfs y fjcorfs%
F aks fakohs phr hircgcrac ahaceths dc cetrctcekakceth jhs gufjcs iucrhe dc
augbh forfdh%
Mufe Gfrjhs
-
7/23/2019 EVALUACIN DEL EFECTO DE UN PROBITICO NATIVO ELABORADOEN BASE A Lactobacillus acidophilus y Bacillus su
6/105
YK
Fj ikefjkzfr uef kaphrtfetc ifsc dc ak vkdf cstudkfetkj forfdczgh prkacrfacetc
f Dkhs phr dfrac jf vkdf c kjuakefrac thdh cstc tkcaph y ihrtfjcgcrac ghe
dcdkgfgke y augbh csiucrzh%
F aks fprcgkfdhs pfdrcs Gfrjhs y @jfegf* phr dfrac thdh su fphyh y
prhtcggke ce ak vkdf uekvcrsktfrkf%
F aks bcrafehs* Gcsfr* Mcfe Gfrjhs y Ekghj* qukcecs ihrafrhe uef pkczf
kaphrtfetc pfrf gujakefr cstf ctfpf dc ak vkdf dhedc ghapfrtkahs augbfs
fegdhtfs y fjcorfs%
F aks fakohs phr ghapfrtkr ahaceths dc dkstrfggke quc skrvkcrhe dc augbh
forfdh durfetc thdh cstc tkcaph%
Fdrkfe Wfetkfoh
-
7/23/2019 EVALUACIN DEL EFECTO DE UN PROBITICO NATIVO ELABORADOEN BASE A Lactobacillus acidophilus y Bacillus su
7/105
YKK
FOPFDCGKAKCETH
F jf CW^C* su Gfrrcrf dc Keocekcrf ce Gkcegkfs Forhpcgufrkfs* phr pfrtkgkpfr
dc eucstrf ihrafgke ahrfj c ketcjcgtufj%
Fj Dkrcgthr @joh% Esthr Wfjths* Ghdkrcgthr Keo% AWg% Oustfvh Ecz y
@khactrkstf Keo% Ykekgkh Sdfy* phr sus fgcrtfdfs rcghacedfgkhecs pfrf cj dcsfrrhjjh
dc cstf kevcstkofgke%
F thdhs jhs dhgcetcs dc jf Gfrrcrf dc Keocekcrf ce Gkcegkfs Forhpcgufrkfs
Wfeth Dhakeoh* phr cj tkcaph kevcrtkdh ce eucstrf ihrafgke y ghapfrtkr sus
ghehgkakceths%
F thdfs jfs pcrshefs quc dc uef u htrf afecrf ghjf`hrfrhe pfrf quc eucstrh
prhycgth scf vkf`jc%
-
7/23/2019 EVALUACIN DEL EFECTO DE UN PROBITICO NATIVO ELABORADOEN BASE A Lactobacillus acidophilus y Bacillus su
8/105
YKKK
FSTHPF
Jfs kdcfs cxpucstfs ce cj prcscetc
trf`fmh dc kevcstkofgke* fs ghah
jhs rcsujtfdhs* dksguske y
ghegjuskhecs she dc cxgjuskvf
rcsphesf`kjkdfd dc jhs futhrcs%
XXXXXXXXXXXXXXXXXXXXXXX
IKPAF
XXXXXXXXXXXXXXXXXXXXXXX
IKPAF
KEDKGC DC GHETCEKDH
GHETCEKDH ^o%
K% KETPHDSGGKE%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%% 6KK% PCYKWKE DC JKTCPFTSPF%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%% 4
0%6% WKWTCAF DKOCWTKYH DCJ HJJH @PHKJCP%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%% 4
0%6%6% @hgf%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%% 40%6%0% Jceouf%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%% 3
-
7/23/2019 EVALUACIN DEL EFECTO DE UN PROBITICO NATIVO ELABORADOEN BASE A Lactobacillus acidophilus y Bacillus su
9/105
KR
0%6%7% Csifoh%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%% 30%6%4% @ugbc%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%% 30%6%3% ^rhvcetrgujh%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%% 30%6%9% Ahjjcmf%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%% 3
0%6%?% Ketcstkeh Dcjofdh%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%% 90%6%?%6% Duhdceh%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%% 90%6%?%0% [cyueh%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%% 90%6%?%7% jche%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%% 9
0%6%2% Gkcohs%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%% 90%6%;% Gjhfgf%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%% 90%6%6>% rofehs dkocstkvhs ghapjcacetfrkhs%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%% ?
0%6%6>%6% ^egrcfs%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%% ?0%6%6>%0% Bofdh%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%% ?0%6%6>%7% Ycsgujf kjkfr%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%% ?
0%0% KETCOPKDFD KETCWTKEFJ%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%% ?
0%7% IFGTHPCW VSC KEIJS[CE CE JF WFJSD KETCWTKEFJ%%%%%%% ;0%4% IJHPF @FGTCPKFEF DCJ TPFGTH DKOCWTKYH%%%%%%%%%%%%%%%%%%%%%% 660%3% DCWFPPHJJH DC JF AKGPHIJHPF KETCWTKEFJ%%%%%%%%%%%%%%%%%%% 600%9% AKGPHIJHPF CE JHW DKWTKETHW TPFAHW KETCWTKEFJCW% 600%?% ISEGKHECW [ CVSKJK@PKH DC JF IJHPF KETCWTKEFJ%%%%%%%% 640%2% DCWCVSKJK@PKH AKGPH@KFEH KETCWTKEFJ%%%%%%%%%%%%%%%%%%%%%%%%%%%% 640%;% CRGJSWKE GHA^CTKTKYF%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%% 630%6>% KETCPFGGKHE DCJ WKWTCAF KEASEHJOKGH [ CJ
TPFGTH OFWTPH
KETCWTKEFJ%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%
69
0%6>%6% rhpkcdfdcs dcj augus dcj ketcstkeh y dc jf `frrcrf aughsf%%% 6?0%66% JHW ^PH@KTKGHW%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%% 6?0%60% KA^HPTFEGKF DC JHW PH@KTKGHW%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%% 62
0%60%6% Grktcrkhs pfrf ue prh`ktkgh%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%% 6;0%60%0% Acgfeksahs dc fggke dc jhs prh`ktkghs%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%% 6;0%60%7% @cecikgkhs dc jhs prh ktkghs ce prhduggke fekafj%%%%%%%%%%%%%%%% 0>
0%67% @FGTCPKFW GKDH JGTKGFW%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%% 000%67%6% @fgtcrkfs prhdugthrfs dc gkdh jgtkgh%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%% 00
0%64% GFPFGTCPKWTKGFW DC JFW @FGTCPKFW GKDH JGTKGFW% 000%64%6% Gfrfgtcrstkgfs dcJfgth`fgkjjus fgkdhpbkjus%%%%%%%%%%%%%%%%%%%%%%%%%%% 00
0%64%0% Gjfskikgfgke tfxheakgf dcJfgth`fgkjjus%%%%%%%%%%%%%%%%%%%%%%%%%%%%%% 040%64%7% Gfrfgtcrstkgfs dc@fgkjjus su`tkjks%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%% 040%64%7 Gjfskikgfgke Tfxheakgf dcj Oecrh@fgkjjus%%%%%%%%%%%%%%%%%%%%%%%% 030%64%4% Gfrfgtcrstkgfs dc@kikdh`fgtcrkua%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%% 03
0%63% @FGTCPKHGKEFW%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%% 030%63%6% rhduggke dc `fgtcrkhgkefs%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%% 090%63%0% Acgfeksahs dc fggke dc jfs `fgtcrkhgkefs%%%%%%%%%%%%%%%%%%%%%%%%%%%%% 0?
0%69% KETCPFGGKHE DC JHW ^PH@KHTKGHW GHE JF AFTCPKF
HPOEKGF [ CJKAKEFGKE DC AFJHW HJHPCW%%%%%%%%%%%%%%%%%%% 0?KKK% AFTCPKFJCW [ ATHDHW%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%% 0;
7%6% GFPFGTCPKWTKGFW DCJ GFA^H CR^CPKACETFJ%%%%%%%%%%%%%%%%%% 0;7%6%6% S`kgfgke phjtkgf%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%% 0;7%6%0% S`kgfgke ochorikgf%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%% 0;
-
7/23/2019 EVALUACIN DEL EFECTO DE UN PROBITICO NATIVO ELABORADOEN BASE A Lactobacillus acidophilus y Bacillus su
10/105
R
7%6%7% S`kgfgke cghjokgf%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%% 0;7%0%
AFTCPKFJCW%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%
7>
7%0%6% Kesuahs%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%% 7>7%0%0% Cqukphs%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%% 7>7%0%7% Kestruaceths%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%% 767%0%4% Bcrrfakcetfs%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%% 767%0%3% Aftcrkfjcs y cqukphs dc jf`hrfthrkh%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%% 76
7%7% ACTHDHJHOKF%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%% 707%7%6% Ifsc dc jf`hrfthrkh%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%% 70
7%7%6%6% Pcghjcggke dc aucstrfs%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%% 707%7%6%0% Wkca`rf ce jhs acdkhs dc gujtkvh%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%% 707%7%6%7% ^urkikgfgke dc ghjhekfs%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%% 707%7%6%4% Kdcetkikgfgke dc gcpfs eftkvfs%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%% 77
7%7%6%3% Gfrfgtcrkzfgke dc ghegcetrfgke dc fgtcrkfs%%%%%%%%%%%%%% 777%7%6%9% Ihraujfgke dcj prh ktkgh%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%% 777%7%0% Dksch cxpcrkacetfj%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%% 77
7%7%0%6% Ifgthrcs f prh`fr%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%% 777%7%0%0% Trftfakceths f ghapfrfr%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%% 747%7%0%7% Tkph dc dksch%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%% 747%7%0%4% H`scrvfgkhecs%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%% 747%7%0%3% Gfrfgtcrstkgfs dc jf SC%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%% 74
7%7%7% Fejksks cstfdstkgh%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%% 737%7%7%6% Csqucaf dcj fejksks dc vfrkfezf%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%% 737%7%7%0% Fejksks iuegkhefj%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%% 73
7%7%4% Dfths thafdhs y athdhs dc cvfjufgke%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%% 737%7%4%6% csh%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%% 737%7%4%0% Ahrtfjkdfd%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%% 797%7%4%7% Ghevcrske fjkacetkgkf%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%% 797%7%4%4% Fejksks fgtcrkhjokgh%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%% 79
7%7%3% Athdhs cspcgikghs dc afecmh dcj cxpcrkaceth%%%%%%%%%%%%%%%%%%%%%%% 797%7%3%6% Jkapkczf y dcskeicggke dcj ofjpe%%%%%%%%%%%%%%%%%%%%%%%%%%%%%% 797%7%3%0% rcpfrfgke fetcs dc jf rcgcpgke dc jhs phjjkths%%%%%%%%%% 7?7%7%3%7% Pcgcpgke dc jhs phjjkths%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%% 7?7%7%3%4% ^rhorfaf dc vfguefgke%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%% 7?7%7%3%3% Afecmh%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%% 72
7%7%3%9% ^rhthghjh dcj prh`ktkgh%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%% 72KY% PCWSJTFDHW [ DKWGSGKHE%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%% 7;
4%6% IFWC DC JF@HPFTHPKH%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%% 7;4%6%6% Kdcetkikgfgke dc jhs fksjfakceths `fgtcrkfehs%%%%%%%%%%%%%%%%%%%%%%%%%%% 7;4%6%0% Kdcetkikgfgke ahjcgujfr dc jfs gcpfs eftkvfs%%%%%%%%%%%%%%%%%%%%%%%%%%%% 7;4%6%7% Ghetrhj dc ghjhekfs vkf`jcs dc jfs gcpfs pfrf jf ihraujfgke
dcj prh`ktkgh%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%% 4>4%6%4% Pcguceth dc fcrh`khs%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%% 4>
4%0% IFWC DC GFA^H%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%% 4>4%0%6% Ofefegkf dc pcsh%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%% 4>
4%0%0% Ghevcrske fjkacetkgkf%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%% 444%0%7% Ahrtfjkdfd%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%% 42
-
7/23/2019 EVALUACIN DEL EFECTO DE UN PROBITICO NATIVO ELABORADOEN BASE A Lactobacillus acidophilus y Bacillus su
11/105
RK
4%0%4% Fejksks fgtcrkhjokgh%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%% 374%0%3% Fejksks cgheakgh%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%% 34
Y% GHEGJSWKHECW%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%% 3?YK% PCGHACEDFGKHECW%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%% 3;
YKK% PCWSACE%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%% 9>YKKK% WSAFP[%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%% 96KR% @K@JKHOPFIF%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%% 90R% FECRHW%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%% 9;
EDKGC DC GSFDPHW
GSFDPH E ^o%
Gufdrh 6% Tf`jf dc jf dkvcrskdfd `fgtcrkfef dcj trfgth ofstrhketcstkefj dc phjjhs*
ce iueskhe dc jf vfrkfgkhe dcj pB y cj tkcaph acdkh dc rctcegke ce
akeuths "TAP+ dc jf dkocstf ce jf ifsc shjkdf%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%% 67
Gufdrh 0% Tf`jf dc fgtcrkfs fgkdh jgtkgfs usfdfs ghah prh`ktkghs%%%%%%%%%%%%%%%%%%% 06Gufdrh 7% Tf`jf dc jf gjfskikgfgke tfxheakgf dcj ocecrh@fgkjjus%%%%%%%%%%%%%%%%%%%%% 03
-
7/23/2019 EVALUACIN DEL EFECTO DE UN PROBITICO NATIVO ELABORADOEN BASE A Lactobacillus acidophilus y Bacillus su
12/105
RKK
Gufdrh 4% Tf`jf dc cqukphs utkjkzfdhs ce jf`hrfthrkh%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%% 76Gufdrh 3% Tf`jf dc aftcrkfjcs y rcfgtkvhs utkjkzfdhs ce jf`hrfthrkh%%%%%%%%%%%%%%%%%%%%% 76Gufdrh 9% Csqucaf dcj fejksks dc vfrkfezf pfrf jhs ifgthrcs ce cstudkh%%%%%%%%%%%%% 73Gufdrh ?% ^ruc`fs ahrihjokgfs dc jhs oecrhs Jfgth`fgkjjus y
@fgkjjus%%%%%%%%%%%%%
7;
Gufdrh 2 ^ruc`fs `khquakgfs dc jhs oecrhsJfgth`fgkjjus y@fgkjjus%%%%%%%%%%%%%% 7;Gufdrh ;%FDCYF pfrf acdkr cj cicgth dc dkicrcetcs dhsks y prh`ktkghs sh`rc cj
pcsh ce phjjhs @rhkjcr ce Wfeth Dhakeoh%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%% 46
Gufdrh 6>%FDCYF pfrf acdkr cj cicgth dc dkicrcetcs dhsks* prh`ktkghs y
phgfs sh rc cj pcsh ce phjjhs @rhkjcr ce Wfeth Dhakeoh%%%%%%%%%%%%%%% 46
Gufdrh 66% ruc`f dc Tulcy fj 3# pfrf jhs prhacdkhs dc pcsh%%%%%%%%%%%%%%%%%%%%%%%%%%%% 40Gufdrh 60%FDCYF pfrf acdkr cj cicgth dc dkicrcetcs dhsks y prh`ktkghs sh`rc
jf ghevcrske fjkacetkgkf ce phjjhs `rhkjcr ce Wfeth Dhakeoh* 0>6>%% 43Gufdrh 67%FDCYF pfrf acdkr cj cicgth dc dkicrcetcs dhsks* prh`ktkghs y
phgfs ce ghevcrske fjkacetkgkf ce phjjhs @rhkjcr ce Wfeth
Dhakeoh* 0>6>% 43Gufdrh 64%^ruc`f dc Tulcy fj 3# pfrf jhs prhacdkhs dc jf ghevcrske
fjkacetkgkf%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%% 43Gufdrh 63%FDCYF pfrf acdkr cj cicgth dc dkicrcetcs dhsks dc prh`ktkgh eftkvh
y ghacrgkfj* sh`rc jf ahrtfjkdfd ce phjjhs `rhkjcr ce Wfeth
Dhakeoh* 0>6>%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%% 4;Gufdrh 69%FDCYF pfrf acdkr cj cicgth dc dkicrcetcs dhsks* prh`ktkghs y
phgfs sh`rc jf ahrtfjkdfd ce phjjhs @rhkjcr ce Wfeth Dhakeoh*
0>6>%% 4;Gufdrh 6?% ruc`f dc Tulcy fj 3# pfrf jhs prhacdkhs dc Pfz dc ahrtfjkdfd%%%%% 4;Gufdrh 62%Ghsths vfrkf`jcs y `cecikgkhs pfrf jhs trftfakceths ghe jf fdkgke dc
prh`ktkghs f `fsc dc J% fgkdhpbkjus y @% su`tkjks%%%%%%%%%%%% 34Gufdrh 6;%Fejksks afrokefj dc trftfakceths eh dhakefdhs%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%% 33
KEDKGC DC IKOSPFW
IKOSPF E ^o%
Ikourf 6% pB ce dkicrcetcs pfrtcs dcj skstcaf dkocstkvh dcj fvc%%%%%%%%%%%%%%%%%%%%%%%%%% 4Ikourf 0% ^rkegkpfjcs oecrhs dc `fgtcrkfs ce cj gkcoh dc phjjhs* `fsfdhs ce
scgucegkfgke FDEr 69W%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%% 67Ikourf 7% Grhquks dc u`kgfgke dcj juofr cxpcrkacetfj%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%% 0;
-
7/23/2019 EVALUACIN DEL EFECTO DE UN PROBITICO NATIVO ELABORADOEN BASE A Lactobacillus acidophilus y Bacillus su
13/105
RKKK
Ikourf 4% Cicgth dc dkicrcetcs dhsks dc prh`ktkgh eftkvh y ghacrgkfj sh`rc cj
pcsh ce phjjhs rhkjcr f jhs 40 dfs* ce Wfeth Dhakeoh* 0>6>%%%%%%%%%%%% 47Ikourf 3% Fejksks dc ghrrcjfgke dcj prh`ktkgh eftkvh pfrf jf vfrkf`jc pcsh ce
phjjhs `rhkjcr f jhs 40 dfs* ce Wfeth Dhakeoh* 0>6>%% 47Ikourf 9% Fejksks dc ghrrcjfgke dcj prh`ktkgh ghacrgkfj pfrf jf vfrkf`jc
pcsh ce phjjhs rhkjcr f jhs 40 dfs* ce Wfeth Dhakeoh* 0>6> 44Ikourf ?% Cicgth dc dkicrcetcs dhsks dc prh`ktkgh eftkvh y ghacrgkfj sh`rc jf
ghevcrske fjkacetkgkf ce phjjhs `rhkjcr ce Wfeth Dhakeoh* 0>6>%%%% 4?Ikourf 2% Fejksks dc ghrrcjfgke dcj prh`ktkgh eftkvh pfrf jf vfrkf jc
ghevcrske fjkacetkgkf ce phjjhs `rhkjcr f jhs 40 dfs* ce Wfeth
Dhakeoh* 0>6>% 4?Ikourf ;% Fejksks dc ghrrcjfgke dcj prh`ktkgh ghacrgkfj pfrf jf vfrkf`jc
ghevcrske fjkacetkgkf ce phjjhs `rhkjcr f jhs 40 dfs* ce Wfeth
Dhakeoh* 0>6>% 42Ikourf 6>% Cicgth dc dkicrcetcs dhsks dc prh`ktkgh eftkvh y ghacrgkfj sh`rc jf
rfz dc ahrtfjkdfd ce phjjhs rhkjcr ce Wfeth Dhakeoh* 0>6>%%%%%%%%%%%% 3>Ikourf 66% Cicgth dc dkicrcetcs dhsks dc prh`ktkgh eftkvh y ghacrgkfj sh`rc jf
ahrtfjkdfd cxprcsfdf ce phrgcetfmc ce phjjhs `rhkjcr ce Wfeth
Dhakeoh* 0>6>%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%% 36Ikourf 60% Fejksks dc ghrrcjfgke dcj prh`ktkgh eftkvh pfrf jf vfrkf jc
ahrtfjkdfd ce phjjhs `rhkjcr f jhs 40 dfs* ce Wfeth Dhakeoh*
0>6>% 30Ikourf 67% Fejksks dc ghrrcjfgke dcj prh`ktkgh ghacrgkfj pfrf jf vfrkf`jc
ahrtfjkdfd ce phjjhs `rhkjcr f jhs 40 dfs* ce Wfeth Dhakeoh*
0>6>% 30Ikourf 64% Gurvf dc `cecikgkhs ecths%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%% 33
-
7/23/2019 EVALUACIN DEL EFECTO DE UN PROBITICO NATIVO ELABORADOEN BASE A Lactobacillus acidophilus y Bacillus su
14/105
RKY
-
7/23/2019 EVALUACIN DEL EFECTO DE UN PROBITICO NATIVO ELABORADOEN BASE A Lactobacillus acidophilus y Bacillus su
15/105
K% KETPHDSGGKE
Jf Kedustrkf Fvghjf Cgufthrkfef ce jhs jtkahs hgbh fhs bf kegrcacetfdh suprhduggke f dkicrcegkf dc htrhs tkphs dc gfrec* ce eucstrh pfs cj fuaceth ce cj
ghesuah dc gfrec dc phjjh bf skdh auy skoekikgftkvh* cs fs ghah cetrc cj 0>>4 y cj
0>>2 sc h`scrv ue kegrcaceth dcj 07# fj pfsfr dc 06*9 f 09*9 lo(bf`(fh cj
ghesuah pr!gpktf* dc`kedhsc f jf orfe hicrtf dc cstc prhdugth "Ykjjfakzfr* 0>>2+%
Cj Gcesh Fvghjf Efgkhefj 0>>2 rcfjkzfdh phr cj AFO* WCWF* GHEFYC y
FACYCF* df f ghehgcr quc jf prhduggke iuc dc 063 >;9 akjjhecs dc fvcs* skcedh
6;2 43> akjjhecs jf jecf dc `rhkjcrs* ; 67> akjjhecs dc phsturf* 3 32> akjjhecs
afgbhs quc ghrrcsphedce f jhs efgkakceths dc jf jecf phsturf* 6 2>> akjjhecs
rcprhdugthrfs pcsfdfs y 679 akjjhecs dc rcprhdugthrfs jkvkfefs "Ouzae 0>>2+%
^frf cj Cghehakstf Cstc`fe ]fa`rfeh Ocrcetc Pcokhefj dc ^PHEFGF Wfeth
Dhakeoh* acegkhef quc cj ghesuah dc phjjhs y sus dcrkvfdhs grcgc shstcekdfacetc
ce cj acrgfdh cgufthrkfeh y sc bf ghevcrtkdh ce jf iucetc dc prhtcef as `frftf%
^frf sftksifgcr cstc acrgfdh caprcsfs ghah ^rhefgf qukce ghe as dcj 43 # dc
pfrtkgkpfgke ce cj acrgfdh* jkdcrf jf prhduggke prhgcsfedh ue thtfj dc 4 93>*6;
The dc gfrec dc phjjh(fh kegjuycedh fvghjfs prhpkfs c ketcorfdfs ghegcetrfdfs ce
jf zhef dc Wfeth Dhakeoh%
Dc`kdh f jhs athdhs dc afecmh ketceskvhs fgtufjcs jhs fekafjcs dc orfemf*
iuedfacetfjacetc jfs fvcs* she auy susgcptk`jcs f dcs`fjfegcs fgtcrkfehs cetrkghs
quc jjcvfe f uef kesuikgkcetc ghevcrske dc jhs fjkaceths y f uef dksakeugke ce jfrcspucstf zhhtgekgf% ^frf ftceufr cstfs dkikgujtfdcs* jfs dkctfs she supjcacetfdfs
ghe fetk`ktkghs* jhs gufjcs bfe ahstrfdh scr cicgtkvhs ce jf dksakeugke dc jhs
trfsthrehs dkfrrckghs y ce jf prhahgke dcj grcgkakceth fekafj "Akjkfe* 0>>3+%
Jf `khtcgehjhof cst fphrtfedh f jhs eutrkgkhekstfs uef eucvf ocecrfgke dc
prhdugths quc she fjtcreftkvfs vkf`jcs f jhs fetk`ktkghs prhahthrcs dc grcgkakceth y
quc pucdce scr prhahgkhefdhs ghah efturfjcs y scourhs pfrf cj fekafj* cj
-
7/23/2019 EVALUACIN DEL EFECTO DE UN PROBITICO NATIVO ELABORADOEN BASE A Lactobacillus acidophilus y Bacillus su
16/105
0
ghesuakdhr y cj acdkh fa`kcetc ghah she jhs afefehjkohsfgfrkdhs* cj scjcekh
hroekgh* prh`ktkghs* keujkef y irugtuhjkohsfgfrkdh* ghedrhktke sujifth y
ojughsfakef* fetkhxkdfetcs y gkdhs hroekghs%
Jhs prh`ktkghs she dcikekdhs ghah ue supjcaceth fjkacetkgkh quc `cecikgkf jf
sfjud dcj bhspcdcrh% Ocecrfjacetc cs gheskdcrfdh quc csths jjcvfe fgf`h ue
acmhrfakceth ce cj `fjfegc akgrh`kfj% Wke ca`froh gfdf vcz cs as gjfrh cj
`cecikgkh quc csths tkcece ce jf sfjud vf keauekdfd% Cj trfgth ofstrhketcstkefj
guapjc vfrfs iuegkhecs tfjcs ghah jf f`shrgke y dkocstke dc eutrkcetcs% Sef dc
cstfs cs quc cj ketcstkeh cs bhspcdcrh dc uef ghapjcmf aczgjf dc akgrh`khs* csths
she pfrtc dc eucstrf akgrhijhrf jhs gufjcs mucofe ue pfpcj kaphrtfetc ce jf sfjud%@kikdh`fgtcrkua yJfgth`fgkjjus she uef iucrtc fshgkfgke quc afetkcece cj `fjfegc
akgrh`kfj dc jhs ketcstkehs "Wfjvfdhr y Gruz* 0>>;+%
Orfe pfrtc dcj skstcaf keauec cst dcdkgfdh f prhtcocr cj trfgth
ofstrhketcstkefj* phr csh cxkstce skstcafs fdkgkhefjcs quc prhtcoce cj skstcaf
dkocstkvh% Se cjcaceth gjfvc ce jf dcicesf dcj skstcaf dkocstkvh cs jf akgrhijhrf
cedocef% Jfs `fgtcrkfs `ceikgfs ghapktce ghe jhs pftocehs phr jhs sktkhs dcfdbcske y phr eutrkcetcs* cs phr cjjh quc sc ecgcsktf dc eucvhs ceihqucs pfrf jkaktfr
jf ghegcetrfgke dc pftocehs ce cj trfgth ofstrhketcstkefj "Wprkeo 0>>4+%
@frrcrf "0>>2+* shstkcec quc jf prhduggke fvghjf gfdf df dc`c scr as
ghapctktkvf y sus rcsujtfdhs dc`ce scr cxgcjcetcs* uef fjtcreftkvf pfrf acmhrfr jf
prhduggke she jhs jjfafdhs prhdugths prh`ktkghs quc ghetkcece akgrhhrofeksahs
vkvhs y fgtkvhs quc ghjhekzfe cj trfgth dkocstkvh%
Wcoe Ahrceh "6;;;+* gufedh efgce jhs phjjucjhs su ketcstkeh prgtkgfacetc
cst cstrkj* dcsfrrhjjedhsc su ijhrf ketcstkefj durfetc jfs prkacrfs scafefs dc vkdf*
dhedc prcdhakefe `fgtcrkfs dcj oecrh Jfgth`fgkjjus* Cetcrhghggus y@fgkjjus* cstf
ijhrf futgthef cs cspcgikgf y cst dctcrakefdf phr jfs ghedkgkhecs iskgfs y
quakgfs cxkstcetcs ce su fpfrfth dkocstkvh% ^hr cstf rfze cs kaphrtfetc cj ush dc
prh`ktkghs pfrf dcsfrrhjjfr ce cj fvc uef ghjhekzfgke akgrh`khjokgf cicgtkvf dcj
trfgth dkocstkvh%
-
7/23/2019 EVALUACIN DEL EFECTO DE UN PROBITICO NATIVO ELABORADOEN BASE A Lactobacillus acidophilus y Bacillus su
17/105
7
Cj dcsghehgkakceth dc jhs `cecikgkhs dc jfs `fgtcrkfs prh`ktkgfs ce jf
prhdugtkvkdfd bfgc quc cstfs eh scfe utkjkzfdfs phr pfrtc dc jhs fvkgujthrcs% Jf
ph`jfgke quc sc `cecikgkfr* scre thdhs jhs prhdugthrcs fvghjfs dc jf zhef y
tgekghs dcdkgfdhs f cstf rcf* kedkrcgtfacetc sc cspcrf jjcofr f htrhs fvkgujthrcs
dcdkgfdhs f jf prhduggke dc ofjjkefs dc phsturf pfrf quc bfofe ush dc jfs `fgtcrkfs
fgkdh jgtkgfs y h`scrvce jhs `cecikgkhs%
@fsfdh ghe csths fetcgcdcetcs sc rcfjkz jf kevcstkofgke thafedh ce gucetf
jhs skoukcetcs h`mctkvhs%
OCECPFJ
Dctcrakefr jhs cicgths dc jf kegjuske dc prh`ktkghs durfetc jf ctfpf dc
grkfezf ce phjjhs `rhkjcrs "Jecf PHWW!7>2+* pfrf cj acmhrfakceth dc jhs
pfractrhs sfektfrkhs* prhdugtkvhs y cgheakghs%
CW^CGIKGHW
Fksjfr c kdcetkikgfr jfs gcpfs eftkvfs dc Jfgth`fgkjjus fgkdhpbkjus y @fgkjjus
su`tkjks%
Ihraujfr cj prh`ktkgh f `fsc dcJfgth`fgkjjus fgkdhpbkjus y@fgkjjus su`tkjks%
Dctcrakefr jf rcjfgke dc jf kegjuske dc prh`ktkghs f trfvs dcj ghesuah dc
fouf ce jf ofefegkf dc pcsh pfrf phjjhs @rhkjcr Phss 7>2%
Cvfjufr jf fdkgke dc prh`ktkghs ce jf dkctf* ce rcjfgke ghe jf Ghevcrske
Fjkacetkgkf ce phjjhs @rhkjcr Phss 7>2%
Dctcrakefr jf tfsf dc Ahrtfjkdfd%
Dctcrakefr cj trftfakceth as cgheakgh pfrf kegjukr cj ush dc prh`ktkghs cejf dkctf utkjkzfedh jf acthdhjhof ^crrke ct fj%
Jf bkptcsks pjfetcfdf pfrf jf kevcstkofgke cs* jf kegjuske dc prh`ktkghs durfetc jf
ctfpf dc grkfezf acmhrfr jhs pfractrhs sfektfrkhs* prhdugtkvhs y cgheakghs dc jhs
prhdugthrcs ce phjjhs @rhkjcr Phss!7>2
-
7/23/2019 EVALUACIN DEL EFECTO DE UN PROBITICO NATIVO ELABORADOEN BASE A Lactobacillus acidophilus y Bacillus su
18/105
4
KK% PCYKWKE DC JKTCPFTSPF
0%6% WKWTCAF DKOCWTKYH DCJ HJJH
Wcoe Bckez "0>>>+* cj ketcstkeh cs ue rofeh ghapjcmh quc ihraf pfrtc dcj
trfgth ofstrhketcstkefj y cs cj pfsh h`jkofdh dc jhs eutrkaceths quc skrvce dc `fsc
pfrf cj actf`hjksah* cj grcgkakceth y cj afetcekakceth%
Mcesce "0>>6+ gktfdh phr Arhz "0>>4+* h`scrv quc jf icracetfgke ostrkgf ce
cj ketcstkeh dcjofdh df`f juofr f uef orfe gfetkdfd dc gkdh jgtkgh* akcetrfs quc jf
icracetfgke ce cj gkcoh y ce cj ghjhe prhdugf* prcdhakefetcacetc* gkdh fgtkgh*prhpkekgh y `utrkgh% Jf gfetkdfd thtfj dc gkdhs orfshs dc gfdcef ghrtf cxkstcetc ce
cj trfgth dkocstkvh sc bfjjf ghrrcjfgkhefdf ghe jf gfetkdfd dc sustrfth "ik`rf+ quc tkcec
dksphek`jc jf akgrhijhrf ketcstkefj% Jh gufj cs kaprcsgkedk`jc rcfjkzfr ue fmustc f
trfvs dcj fouf dc `c`kdf%
Ikourf 6% pB ce dkicrcetcs pfrtcs dcj skstcaf dkocstkvh dcj fvc%Iucetc=bttp=((www%ceohrakx%gha(AF!fvkgujturf(eutrkgkhe(frtgujhs(sfjud!ketcstkefj!gjfvc!prhdugtkvkdfd!t362(p>%bta
0%6%6% @hgf
Wcoe Afrgl "0>>0+* cj phjjh eh tkcec jf`khs* pfjfdfr `jfedh* acmkjjfs y
dkcetcs* pcrh tkcec afed`ujfs ghrecfs supcrkhr c keicrkhr quc gkrguedfe jf `hgf< jf
supcrkhr sc cegucetrf uekdf fj grech* akcetrfs quc jf keicrkhr cs ghjofetc%
-
7/23/2019 EVALUACIN DEL EFECTO DE UN PROBITICO NATIVO ELABORADOEN BASE A Lactobacillus acidophilus y Bacillus su
19/105
3
0%6%0% Jceouf
Cs dc ihraf dc gf`czf dc ijcgbf* su iuegke cs dc prcbceske* scjcggke y
dcojugke dcj fjkaceth% Ce cstc rofeh dcj fpfrfth dkocstkvh sc cegucetrf jf cezkaf
fakjfsf "Afrgl* 0>>0+%
0%6%7% Csifoh
Cesakeocr "0>>>+* shstkcec quc cs skapjcacetc ue ghedugth h tu`h quc skrvc
pfrf ghedugkr jhs fjkaceths y cj fouf dcsdc jf `hgf bfstf cj `ugbc* y dc fjj bfstf jf
ahjjcmf%0%6%4% @ugbc
Wcoe vkjf "0>>3+* cj `ugbc dcsfrrhjjf jf iuegke dc rofeh dc
fjafgcefakceth fdcas dc dfr pfsh fj fjkaceth bfgkf cj fpfrfth dkocstkvh% Ce cstc
rofeh* cj fjkaceth sc rcahmf ghe fouf y sfjkvf dc jf `hgf< dc ahdh quc cj `ugbc dc
jfs fvcs pcraktc ghesuakr orfedcs gfetkdfdcs dc fjkaceth% Cj ghetcekdh dcj `ugbc cs
skcaprc gkdh ghe ue pB 3%
0%6%3% ^rhvcetrgujh
Afrgl "0>>0+ fikraf quc ce cj prhvcetrgujh cs dhedc sc prhdugc cj muoh
ostrkgh% Jfs gjujfs ojfedujfrcs scgrctfe pcpskef* uef cezkaf quc fyudf f jf
dkocstke dc prhtcefs* y fgkdh gjhrbdrkgh%
0%6%9% Ahjjcmf
Jf ahjjcmf cs dc ihraf hvfj ghe dhs f`crturfs* uef ghauekgf ghe cj
prhvcetrgujh y jf htrf bfgkf cj duhdceh% Wu prkegkpfj iuegke cs ahjcr y fpjfstfr jhs
fjkaceths orucshs% Jf fgtkvkdfd ahthrf dc jf ahjjcmf cs dc gfrgtcr rtakgh* dc ahdh
quc fpfrcgc uef ghetrfggke dc jhs dhs asgujhs% ^rcscetf ue pB dc 4*>9 phr jh quc
tkcec uef rcfggke gkdf "Cesakeocr 0>>>+%
-
7/23/2019 EVALUACIN DEL EFECTO DE UN PROBITICO NATIVO ELABORADOEN BASE A Lactobacillus acidophilus y Bacillus su
20/105
9
0%6%?% Ketcstkeh Dcjofdh
Wcoe vkjf "0>>3+* ghacetf quc cj ketcstkeh dcjofdh ce jfs fvcs sc dkvkdc ce=
duhdceh* ycyueh c jche y sc dcsgrk`c f ghetkeufgke=
0%6%?%6% Duhdceh
Jf rcfggke dcj ghetcekdh dcj duhdceh cs gfsk skcaprc gkdf* prcscetfedh ue
pB dc 9*7 phr jh quc phsk`jcacetc cj muoh ostrkgh cmcrgc fqu jf afyhr pfrtc dc su
fggke%
0%6%?%0% [cyueh
Cj ycyueh ghestf dc uefs dkcz fsfs pcqucfs* dkspucstfs ghah uef oukrefjdf y
suspcedkdfs dc uef pfrtc dcj acscetcrkh% ^rcscetf ue pB dc ?*>4%
0%6%?%7% jche
Cj jche* guyf cstrugturf cs cstkrfdf y sc cegucetrf ce cj gcetrh dc jf gfvkdfd
f`dhakefj% Cj pB cs dc ?*3;%
0%6%2% Gkcohs
Afrgl "0>>0+ y Cesakeocr "0>>>+ shstkcece quc eh sc ghehgc jf iuegke
cxfgtf dc jhs sfghs gkcohs* pcrh cs cvkdcetc quc tkcec quc vcr ghe jf dkocstke% Cj pBdcj gkcoh dcrcgbh cs dc ?*>2 akcetrfs quc cj pB dcj gkcoh kzqukcrdh cs dc ?*60% Wc
grcc quc jf iuegke dc jhs gkcohs cs dc f`shrgke y quc cste rcjfgkhefdhs ghe jf
dkocstke dc gcjujhsf%
0%6%;% Gjhfgf
Wcoe Cesakeocr "0>>>+* jf gjhfgf cs ue rofeh ghae f jhs trfgths urkefrkh*
dkocstkvh y rcprhdugtkvh% ^hr jh tfeth jf hrkef y jfs bcgcs sc cjkakefe muetfs%
-
7/23/2019 EVALUACIN DEL EFECTO DE UN PROBITICO NATIVO ELABORADOEN BASE A Lactobacillus acidophilus y Bacillus su
21/105
?
0%6%6>% rofehs Dkocstkvhs Ghapjcacetfrkhs
0%6%6>%6% ^egrcfs
Cstf dcetrh dcj fsf duhdcefj dcj ketcstkeh dcjofdh y scgrctf cj muoh
pfegrctkgh guyfs gkegh phdcrhsfs cezkafs fyudfe f jf dkocstke dc fjakdhecs* orfsf
y prhtcefs "Cesakeocr* 0>>>+%
0%6%6>%0% Bofdh
Afrgl "0>>0+* shstkcec quc cst ihrafdh phr dhs orfedcs j`ujhs% Cetrc susiuegkhecs cstf jf dc scgrctfr jf `kjks* quc cs ue jqukdh jkocrfacetc pcofmhsh*
fafrkjjh!vcrdhsh* y quc ghetkcec gkdhs `kjkfrcs* quc fyudfe f jf dkocstke* dc jfs
orfsfs% Wu prkegkpfj iuegke gheskstc ce ecutrfjkzfr jf fgkdcz dcj duhdceh y dkocrkr
jfs orfsfs%
0%6%6>%7% Ycsgujf kjkfr
rofeh ausgujfr quc fjafgcef jf `kjks* prcscetc ce jf afyhrf dc jhs
vcrtc`rfdhs% Ce gufeth f su cstrugturf jf vcsgujf cst ihrafdf phr uef gu`kcrtf
pcrkthecfj cxtcref "tekgf scrhsf+* uef gfpf acdkf dc tcmkdh ik`rhsh y asgujh jksh
"tekgf ausgujfr+ y uef aca`rfef aughsf ketcref "tekgf aughsf+%Jf `kjks pfsf dcj
bofdh fj ketcstkeh phr dhs ghedugths `kjkfrcs% Cj ghedugth dcrcgbh fjafgcef jf
afyhr pfrtc dc `kjks% Cj ghedugth kzqukcrdh eh sc cesfegbf* phr jh quc uef pcqucf
gfetkdfd dc `kjks pfsf dkrcgtfacetc fj ketcstkeh "Afrgl* 0>>0+%
0%0% KETCOPKDFD KETCWTKEFJ
Jf Ketcorkdfd Ketcstkefj sc dcikec ghah cj iuegkhefakceth ptkah dcj trfgth
ketcstkefj* cj gufj afxkakzf cj dcscapch prhdugtkvh dc jfs fvcs% ^hrquc cj trfgth
ketcstkefj cs ueh dc jhs ifgthrcs prkegkpfjcs dcj dcscapch y rcetf`kjkdfd dc jfs fvcs*
jf Ketcorkdfd Ketcstkefj cs iuedfacetfj pfrf tcecr uef prhduggke rcetf jc% Jf
-
7/23/2019 EVALUACIN DEL EFECTO DE UN PROBITICO NATIVO ELABORADOEN BASE A Lactobacillus acidophilus y Bacillus su
22/105
2
Cetcrktks @fgtcrkfef "C@+ y jf Ghggkdkhsks she jfs prkegkpfjcs facefzfs dc jf
Ketcorkdfd Ketcstkefj "Bhcrr* 0>>;+%
^frf ^fjfgkhs "0>>;+* jf sfjud ketcstkefj dcj `rhkjcrh phjjh dc gfrec* ghehgkdf
tfa`ke ghah ketcorkdfd ketcstkefj cs jf iuegke ptkaf dcj trfgth dkocstkvh* fspcgth
prkahrdkfj ce jf grkfezf dc phjjhs dc gfrec quc jcs pcraktc fjgfezfr cj pcsh y jf
ghevcrske fjkacetkgkf cspcrfdf pfrf jf jecf ocetkgf ce gucstke% Jhs pcjkorhs
ghetrf jf sfjud ketcstkefj* prcscetcs ce thdfs jfs ketcorfgkhecs fvghjfs she jf ghggkdkf
y jf cetcrktks `fgtcrkfef%
Wcoe Akjkfe "0>>3+* jf akgrhijhrf ketcstkefj sc ghaphec ce su afyhrf phr`fgtcrkfs gkdh jgtkgfs< cstf akgrhijhrf cs cscegkfj pfrf dcsghaphecr jfs sustfegkfs
fjkacetkgkfs quc eh iucrhe dkocrkdfs prcvkfacetc* afetcekcedh jf ketcorkdfd dc jf
aughsf ketcstkefj% Fj dcsdh`jfr jhs fjkaceths prhdugce vktfakefs "sh`rc thdh dcj
ghapjcmh bkdrhshju`jc+ y gkdhs orfshs quc fj afetcecr jf cstf`kjkdfd ketcstkefj
jhorfe fuacetfr jf rcspucstf keauec< sc ghehgc quc gufedh csths acgfeksahs she
forcdkdhs phr fjoe focetc cxtcreh cs cj ahaceth kdech pfrf cj fggkhefr dc jfs
`fgtcrkfs prh`ktkgfs%
Dugbftcj "0>>3+* fikraf quc jfs vfs dkocstkvfs dc jfs fvcs fs ghah jfs dc jhs
afaicrhs* fj`crofe uef ijhrf akgrh`khjokgf iucrtc% Cstc cghskstcaf dkocstkvh cst
ce cqukjk`rkh y pcrafecgc ehrafjacetc ghestfetc durfetc thdf jf vkdf dc ue fekafj
fdujth% ^crh cstc cqukjk`rkh sc pucdc pcrtur`fr* gufedh cj fvc suirc forcskhecs= cstrs*
dcscqukjk rkhs eutrkgkhefjcs* vfguefgkhecs* suakekstrh afskvh dc fetk ktkghs y
sustfegkfs quc pcrtur`fe cj vfjhr dcj pB dcj ketcstkeh% Cethegcs* jhs ifgthrcs qucpcrtur`fe cj cqukjk`rkh dc jf ijhrf ketcstkefj* tkcece uef rcpcrguske ce jf sfjud dcj
fekafj%
Wcoe Wfesfjhec "0>>2+* cxkstce fj acehs 4>> cspcgkcs `fgtcrkfefs ce cj OTK*
dc jhs gufjcs sc ghehgce shjfacetc cj 63 # dc cjjfs% Cstf ijhrf* pfrtkgkpf fgtkvfacetc
dc thdhs jhs iceacehs dkocstkvhs* eutrkgkhefjcs y sfektfrkhs dc jfs fvcs% Dc`c cxkstkr
pcrafecetcacetc ue cqukjk`rkh cetrc cj tkph dc ijhrf quc sc ocecrf* jf ketcorkdfd dc jf
-
7/23/2019 EVALUACIN DEL EFECTO DE UN PROBITICO NATIVO ELABORADOEN BASE A Lactobacillus acidophilus y Bacillus su
23/105
;
aughsf ketcstkefj y jf dkctf dc jhs fekafjcs% Wk sc rhapc cstc cqukjk`rkh* pucdc jjcvfr
f uef jcske h ceicracdfd%
0%7% IFGTHPCW VSC KEIJS[CE CE JF WFJSD KETCWTKEFJ
Wcoe Orfefdhs "0>>2+* she=
@frrcrfs iskgfs= Jf ketcorkdfd ketcstkefj sc vc ghaprhactkdf gufedh jf pfrcd
dc jf aughsf cs dffdf* jfs gjujfs cpktcjkfjcs ficgtfdfs h dcstrukdfs* cj
suakekstrh vfsgujfr ketcrruapkdh h cj skstcaf keauec ghaprhactkdhs%
Ifgthrcs cstrcsfetcs= Cj cqukjk`rkh ketcstkefj tfa`ke sc pucdc vcr fjtcrfdh phrifgthrcs dc cstrs ghah afecmh kefdcgufdh h dcicgtuhsh y trfesphrtfgke*
sh`rcph`jfgke* gfa`khs rusghs dcj acdkh fa`kcetc* vfguefgkhecs* ctg%
Ifgthrcs dc jf dkctf= Dcikgkcegkfs eutrkgkhefjcs dc`kdh f= dcs`fjfegc dc jf
iraujf* afj afecmh dcj orfeh* fjtf gfrof `fgtcrkfef ce cj fjkaceth y
akghthxkefs* quc ficgtfe jf sfjud ketcstkefj%
Thxkefs dcj fjkaceth= Jfs thxkefs dcj fjkaceth y txkghs tfa ke ficgtfe jf
ketcorkdfd ketcstkefj% Akgrh ijhrf ketcstkefj= Cj cqukjk`rkh ce jf akgrhijhrf ketcstkefj pcraktc uef
ptkaf ketcorkdfd ketcstkefj% Jfs `fgtcrkfs tkjcs "Jfgth`fgkjjus fgkdhpbkjus* J%
`ujofrks* @kikdh`fgtcrkua `kikdua* @% keifetks* @fgkjjus sp+ mucofe ue pfpcj
kaphrtfetc ce cj ghetrhj dc jf ijhrf y cstkaujfe cj dcsfrrhjjh dc jf pfrcd
ketcstkefj%
Dcihrakdfd dcj pkgh= Sef dcihrakdfd dcj pkgh cvktf ue ghesuah fdcgufdh dc
fjkaceth y pucdc gfusfr dfh fj dcsfrrhjjh ketcstkefj% Cstfdh sfektfrkh= Ceicracdfdcs ghah jf ghggkdkhsks y gjcrf fvkfr ficgtfe
scvcrfacetc jf ketcorkdfd ketcstkefj% Jhs vkrus* bheohs `fgtcrkfs* pfrskths y
thxkefs pucdce scr jf gfusf%
Cedh y Eflfeh "0>>>+ gktfdh phr Akjkfe "0>>3+* cstudkfrhe jhs cicgths dcj
capjch dc ue prh`ktkgh ce phjjhs dc gc`f cj gufj kegjuf cspcgkcs dc Jfgth`fgkjjus*
@fgkjjus* Wtrcpthghggus y Wfggbfrhaygcs ce uef dhsks dc 7 o(lo dc ghegcetrfdh% Cj
prh`ktkgh dcgrcgk cj eacrh dc Cetcrh`fgtcrfgcfc "C%ghjk y Wfjahecjjf+ ce cj
-
7/23/2019 EVALUACIN DEL EFECTO DE UN PROBITICO NATIVO ELABORADOEN BASE A Lactobacillus acidophilus y Bacillus su
24/105
6>
gkcoh% Tfa`ke cstudkhs rcfjkzfdhs phr Afrutf "6;;;+ c keihrafdhs phr @hrthjhzh
"0>>0+ gktfdhs phr Akjkfe "0>>3+* fdakekstrfrhe ue prh`ktkgh f `fsc dc @fgkjjus
su`tkjks f phjjhs dc gc`f* aucstrfe ue fuaceth dc jf ausgujfturf y dksakeugke dc jf
orfsf f`dhakefj* prkegkpfjacetc ce afgbhs% Fdcas h`scrvfrhe quc cj suakekstrh
dc cstc prh`ktkgh dksakeuy cj phrgcetfmc dc `fgtcrkfs pftocefs*
iuedfacetfjacetc* Wfjahecjjf dcsdc ue 9> f ue 0> #%
Phssk* ct fj% "0>>9+< rcfjkzfrhe ue cstudkh usfedh ue prh`ktkgh h`tcekdh f
pfrtkr dcj cpktcjkh dc jf aughsf dcj gkcoh dc phjjhs jk`rcs dc pftocehs dc jf
Wfjahecjjf% Cj prh`ktkgh utkjkzfdh iuc dcstfgfdh ghah uef `khtf fggke dcj
ghetrhjfdhr h kebk`kdhr dc akgrhhrofeksahs pftocehs* jfs fvcs ahstrfrhe ue acmhrdcscapch ce ghapfrfgke ghe jhs trftfakceths dc ghetrhj% Ce ocecrfj*
kedcpcedkcetcacetc dc jhs trftfakceths capjcfdhs ce cstc cxpcrkaceth* sc prhdumh
acmhrcs tfsfs dc grcgkakceth dc jfs fvcs ce rcjfgke f jf jecf cstedfr quc sc utkjkzf%
Ghrts y vkjf "0>>>+* cvfjufrhe cj cicgth dcj prh`ktkgh "@fgkjjus thyhk 6>6>
csphrfs(o+ sh`rc cj ghaphrtfakceth prhdugtkvh ce phjjhs dc ceohrdc guyhs
rcsujtfdhs kedkgfe quc cj prh`ktkgh fdkgkhefdh f jf dkctf pfrf phjjhs dc ceohrdfpcraktce tcecr ue cicgth prhahthr dcj grcgkakceth y dksakeuy jf ahrtfjkdfd% Jhs
rcsujtfdhs ce 4; dfs pfrf ofefegkf dc pcsh iucrhe dkicrcetcs "^: >*>3+< sc ceghetr
cicgth f jf fdkgke dcj prh`ktkgh "0 4>; vs 0 744 o+% Jf ahrtfjkdfd ocecrfj y phr
sedrhac fsgtkgh "WF+ iuc afyhr "^: >*>3+ ce jhs fekafjcs quc ghakcrhe fd jk`ktua
ce ghapfrfgke ghe jhs quc tuvkcrhe rcstrkggke fjkacetfrkf ";*33#* 0*43#* 4*30# y
6%43#* rcspcgtkvfacetc+% Bu`h cicgth "^: >*>3+ f jf fdkgke dcj prh`ktkgh ce WF
">*;># vs 3*>?#+* ghe acehr ahrtfjkdfd%
Bhyhs "0>>2+ utkjkz jhs akgrhhrofeksahs cikgfgcs CA quc ghetcefe `fgtcrkfs
y jcvfdurfs "Jfgth`fgkjjus gfssck 6> uig(aj* Wfggbfrhaygcs gcrcvkskfc 6> uig(aj*
Phdbhpscudhahef pfjustrcs 6> uig(aj+ f ghegcetrfgkhecs afyhrcs f 6>> >>>
uig(aj dc shjugke% Wc cvfjufrhe jhs pfractrhs prhdugtkvhs ghah ofefegkf dc pcsh*
ghevcrske fjkacetkgkf* ahrtfjkdfd fguaujfdf y jf utkjkdfd dc jhs CA ce jf rcduggke
dc jf gfrof dc ghjkihracs thtfjcs prcscetcs ce jf gfaf dc jhs phjjhs% Wc ceghetr quc
jhs CA acmhrfrhe jhs pfractrhs prhdugtkvhs dc jfs fvcs ghah ofefegkf dc pcsh*
-
7/23/2019 EVALUACIN DEL EFECTO DE UN PROBITICO NATIVO ELABORADOEN BASE A Lactobacillus acidophilus y Bacillus su
25/105
66
edkgc dc ghevcrske y ahrtfjkdfd% Jhs CA jhorfrhe rcdugkr jf gfrof dc ghjkihracs
thtfjcs prcscetcs ce cj fa`kcetc dc jhs phjjhs dc ceohrdc% Ce Ofefegkf dc pcsh sc
h`scrv uef dkicrcegkf skoekikgftkvf "p: >*>3+ ce cj pcsh dc jhs afgbhs trftfdhs ghe
CA dc 60>*4 o "3*4#+ ghe uef dhsks dc 6 aj dc prh`ktkgh phr dhs jktrhs dc fouf%
Frfumh "0>>3+* prh` B[DPHCE]KAC prhdugth f `fsc dc prh`ktkghs y
cezkafs ce gufeth f jf f`shrgke dc fjkaceth* ofefegkf dc pcsh y jf dksakeugke dc
ahrtfjkdfd ce cj phjjh dc ceohrdc* h`scrv dkicrcegkf skoekikgftkvf ce jf ofefegkf dc
pcshs f jhs phjjhs trftfdhs ghe B[DPHCE]KAC f jhs 40 dfs dc 0>4?*3 y 6?>9*74
o% uef ghevcrske fjkacetkgkf fjtfacetc skoekikgftkvf pfrf jhs phjjhs ghe
Bydrhcezkac dc 6*20 y cj ghetrhj dc 0*>0%
0%4% IJHPF @FGTCPKFEF DCJ TPFGTH DKOCWTKYH
Ce cj hrofeksah cxkstc uef ijhrf akgrh`kfef dc tkph kedocef y htrf ghapucstf
phr akgrhhrofeksahs quc phtcegkfjacetc pucdce ghaphrtfrsc ghah pftocehs% Ce
trakehs ikskhjokghs sc rcfjkzf uef ska`khsks cetrc cj hrofeksah supcrkhr y jf ijhrf
akgrh`kfef kedocef* cj prkacrh sc ghaphrtf ghah bhspcdfdhr suakekstrfedh f jhsakgrhhrofeksahs cj fa`kcetc pfrf su grcgkakceth y csths jtkahs ghah ska`khetcs*
phece f dksphskgke dcj bhspcdfdhr su gfpfgkdfd dc setcsks "prhtcefs y vktfakefs+
y dc rupturf gcjujfr "gcjujhjksks+% Wke ca`froh gufjqukcr fjtcrfgke dcj cghskstcaf
akgrh`kfeh ghe prdkdfs dc akgrhhrofeksahs dc tkph kedocef* kapjkgf quc
akgrhhrofeksahs trfescetcs* phtcegkfjacetc pftocehs pucdfe thafr phscske dc
jhs ekgbhs quc dcmfrhe vfghs jfs `fgtcrkfs kedocefs "Phdroucz* 6;;4+%
Gbhquc "0>>2+* ceghetr quc jf ketcrfggke cetrc jhs akgrhhrofeksahs y cj TOK
sc rcijcmf ce dkstkeths ekvcjcs= pfrtkgkpfedh ce prhgcshs dkocstkvhs< cvktfedh cj
cstf`jcgkakceth dc akgrhhrofeksahs phtcegkfjacetc pftocehs< prhdugkcedh
actf`hjkths txkghs< kegrcacetfedh jf tfsf dc rcehvfgke cpktcjkfj< dcorfdfedh jf
gfpf dc augkef c kedugkcedh rcspucstf keauektfrkf ghe jf prhjkicrfgke dc gjujfs dc
dcicesf%
-
7/23/2019 EVALUACIN DEL EFECTO DE UN PROBITICO NATIVO ELABORADOEN BASE A Lactobacillus acidophilus y Bacillus su
26/105
60
0%3% DCWFPPHJJH DC JF AKGPHIJHPF KETCWTKEFJ
Tksskcr* gktfdh phr Phdroucz "6;;4+ ghacetf quc cj TOK dcj icth cs cstrkj* sc
cegucetrf ce jh quc sc dcehakef cstfdh fxekgh ikskhjokgh% Wke ca`froh* jf
ghjhekzfgke akgrh`kfef cs cxtrcafdfacetc prcghz y rpkdf* dc ahdh quc f jfs 04!
42 bhrfs dcj efgkakceth sc fjgfezfe ghegcetrfgkhecs dc 6>;!6>6j akgrhhrofeksahs(o
dc bcgcs* gkirfs gcrgfefs f jfs h`scrvfdfs ce cj fdujth* dctcgtedhsc Jfgth`fgkjjus*
ghghs orfa!phsktkvhs* Gjhstrkdkua pcrirkeoces y C% ghjk* fpfrcgkcedh as tfrdc
ghghs orfa!ecoftkvhs y@fgtcrhkdcs%
0%9% AKGPHIJHPF CE JHW DKWTKETHW TPFAHW KETCWTKEFJCW
^frcmf* "0>>3+ fikraf quc cj `ugbc ketcrkhracetc cst gu`kcrth dc uef gfpf dc
cpktcjkh csgfahsh cstrftkikgfdh% Jf ph`jfgke `fgtcrkfef dcj `ugbc cst ghapucstf
afyhrktfrkfacetc phr jfgth`fgkjhs* ghe ue pcquch eacrh dc ghjkihracs y
cstrcpthghghs% Eh sc cegucetrfe ehrafjacetc fefcrh`khs cstrkgths% Jfs `fgtcrkfs sc
bfyfe fshgkfdfs fj cpktcjkh ghe uef gfpf dc aftcrkfj cxtrfgcjujfr* afetcekedhsc f
uef dkstfegkf dc uehs ?ea* cstf`jcgkedhsc pucetcs dc ghetfgth cetrc jfs `fgtcrkfs%Fj pfrcgcr* csths jfgth`fgkjhs ghjhekzfe cj `ugbc f jfs phgfs bhrfs dcj efgkakceth y
pcrskstce f jh jfroh dc jf vkdf dc jfs fvcs "@frrfoe* 0>>>+% Tfa`ke sc pucdc
dkstkeoukr Cstrcpthghggus* Wfjahecjjf* Wbkocjjf* Jfgth`fgkjjus* Csgbcrkgbkf y
Gjhstrkdkua%
Wcoe Fpfmfjfbtk "0>>0+* Cj TOK dc jhs phjjhs fjhmf euacrhsfs cspcgkcs
`fgtcrkfefs% Jhs rcgkcetcs dcsfrrhjjhs ce cj fejksks dc jf ghauekdfd akgrh`kfef phrathdhs `fsfdhs ce FDE bfe dfdh eucvf juz sh`rc jf akgrh`khjhof dcj TOK dc
augbfs cspcgkcs fekafjcs% Jf ikourf 0 aucstrf jhs oecrhs dc `fgtcrkfs as
f`uedfetcs prcscetcs ojh`fjacetc ce cj TOK dc phjjhs%
-
7/23/2019 EVALUACIN DEL EFECTO DE UN PROBITICO NATIVO ELABORADOEN BASE A Lactobacillus acidophilus y Bacillus su
27/105
67
Ikourf 0% ^rkegkpfjcs oecrhs dc `fgtcrkfs ce cj gkcoh dc phjjhs "@fsfdh ce scgucegkfgkeFDEr 69W+
Iucetc= Fpfmfjfbtk "0>>0+
Wcoe Gcrvfetcs "0>6>+* ce cj ketcstkeh dcjofdh jfs cspcgkcs dhakefetcs sheC%
ghjk* Cstrcpthghghs* Cetcrhghggus* Wtbfpyjhghggus y Jfgth`fgkjjus* Tfa`ke
fefcrh`khs h`jkofdhs ghah Cu`fgtcrkua* ^rhpkhek`fgtcrkua* Gjhstrkdkua*
Ocaakocr y Iush`fgtcrkua% Gkcoh= Ghghs Orfa , fefcrh`khs* `fgtcrhkdfgcfc*
Cu`fgtcrkua sp%* @kikdh`fgtcrkua spp%* @uddkeo ghghs* Gjhstrkdkua sp% Ocaakocr
ihrakgkjks% Dc koufj afecrf Gbhquc* "0>>2+* df f ghehgcr uef dcsgrkpgke afs
ghapjctf quc sc kjustrf ce cj Gufdrh 6%
Gufdrh 6% Tf`jf dc dkvcrskdfd `fgtcrkfef dcj trfgth ofstrhketcstkefj dc phjjhs*ce iuegke dc jf vfrkfgke dcj pB y cj tkcaph acdkh dc rctcegke* ce akeuths"TAP+ dc jf dkocstf ce jf ifsc shjkdf%
Wcggkeketcstkefj
Ghetcekdh dkocstkvh@fgtcrkfs
pB TAP
@ugbc 4*3 76!46 Jfgth`fgkjjus,
* Cstrcpthghggus
,
C% ghjk
!
*Wtfpbyjhghggus,*
^rhvcetrgujh 4*4!4*2 7; Cstrcpthghggus,* ghjkihracs!
Ahjjcmf 0*9 77 Jfgth`fgkjjus ,
[cyueh 3*2 ?6!24 Gjhstrkdkua ,
jche 9*7 ;>!;?ghjkihracs!* Cu`fgtcrkua,* @fgtcrhkdcs!*
Wtfpbyjhghggus,* Cstrcpthghggus,
Jfgth`fgkjjus ,
Gkcohs 3*? 66;
Gjhstrkdkua , *@fgtcrhkdcs!*
Cu`fgtcrkua,
* Iush`fgtcrkua!
*@hikdh`fgtcrkf !
-
7/23/2019 EVALUACIN DEL EFECTO DE UN PROBITICO NATIVO ELABORADOEN BASE A Lactobacillus acidophilus y Bacillus su
28/105
64
0%?% ISEGKHECW [ CVSKJK@PKH DC JF IJHPF KETCWTKEFJ
Jhs futhrcs fgcptfe quc jf ijhrf ketcstkefj keijuyc dkrcgtf c kedkrcgtfacetc ce cj
cstfdh dc sfjud dcj bha`rc y jhs fekafjcs f trfvs dc jfs skoukcetcs iuegkhecs=
^rhduggke dc vktfakefs y gkdhs orfshs dc gfdcef ghrtf%
Dcorfdfgke dc sustfegkfs fjkacetkgkfs eh dkocrkdfs%
Ketcorkdfd dcj cpktcjkh ketcstkefj*
Cstaujh dc jf rcspucstf keauektfrkf%
^rhtcggke ircetc f akgrhhrofeksahs cetcrhpftocehs%
Jf cstf`kjkdfd dc jf ijhrf akgrh`kfef ketcstkefj cs kaprcsgkedk`jc pfrf quc cstfs
iuegkhecs pucdfe dcsfrrhjjfrsc* ske ca`froh cj trfgth dkocstkvh eh
cs ue skstcaf `khjokgh gcrrfdh% Dkfrkfacetc ghe cj fjkaceth sc cevfe y fijuyce f jf
juz ofstrhketcstkefj oracecs y sustfegkfs dkvcrsfs eh bf ktufjcs* quc rcsujtfe
ehrafjacetc kehiceskvhs dc`kdh f jhs ajtkpjcs acgfeksahs dc dcicesf quc jfs
`fgtcrkfs phece ce mucoh "Icugbtcr* 0>>3+%
0%2% DCWCVSKJK@PKH AKGPH@KFEH KETCWTKEFJ
Jfs ceicracdfdcs cetrkgfs ghah jf ghggkdkhsks* cj sedrhac dc afjf`shrgke*
ghjk`fgkjhsks y jf cetcrktks ecgrtkgf* she gfusf dc prdkdfs skoekikgftkvfs ce
prhduggke y gfjkdfd dcj phjjh `rhkjcr% Ce jf fgtufjkdfd* cstfs ceicracdfdcs cetrkgfs
sc ghetrhjfe ce jf prgtkgf acdkfetc cj ush dc focetcs fetk!akgrh`kfehs ce cj
fjkaceth y(h cj fouf dc `c`kdf% Jhs focetcs fetk!akgrh`kfehs kegjuyce jhsghggkdkhsttkghs* jhs prhahthrcs dc grcgkakceth fetkakgrh`kfehs "^GFA+ y
acdkgfaceths cspcgikghs% Wke ca`froh* jf grcgkcetc prchgupfgke dc jhs
ghesuakdhrcs sh`rc cj phsk`jc trfsjfdh dc jf rcskstcegkf fetk`ktkgf f jhs pftocehs
gfusfetcs dc ceicracdfdcs buafefs* bf prhvhgfdh jf prhbk`kgke dc jf afyhrf dc
jhs ^GFA y cj ush rcstrkeokdh dc acdkgfaceths ce jf Ghauekdfd Curhpcf% Wk eh sc
dcsfrrhjjf ekeoe prhdugth fjtcreftkvh* cstc ahvkakceth phdrf jjcvfr f ue fuaceth
ce jf kegkdcegkf dc ceicracdfdcs cetrkgfs ghe ue cicgth fdvcrsh ce cj `kcecstfrfekafj y jf prhduggke%
-
7/23/2019 EVALUACIN DEL EFECTO DE UN PROBITICO NATIVO ELABORADOEN BASE A Lactobacillus acidophilus y Bacillus su
29/105
63
Jfs pcrtur`fgkhecs dcj cghskstcaf `fgtcrkfeh dcj buspcd pucdce scr dcikekdfs
ghah dks`fgtcrkhsks% Jf dks`fgtcrkhsks sc rcikcrc f jhs gfa`khs ce cj eacrh h
ghaphskgke dc jfs `fgtcrkfs ketcstkefjcs eh pftocefs dcj ghacesfj quc jc pucdce
hrkokefr pcrtur`fgkhecs dkocstkvfs% Jf dks`fgtcrkhsks eh cs tfeth uef keicggke skeh ue
dcscqukjk`rkh akgrh`kfeh% Wke ca`froh* cs prh`f`jc quc ce augbhs gfshs gjekghs* jf
dks`fgtcrkhsks y jfs keicggkhecs cetrkgfs cste prcscetcs skaujtecfacetc* cxkstkcedh
uef rcjfgke gfusfj% Jf dks`fgtcrkhsks pucdc gfusfr keicggkhecs y jfs keicggkhecs
pucdce gfusfr dks`fgtcrkhsks% Wc bf dcsgrkth* phr cmcapjh* quc phjjhs keicgtfdhs ghe
ghggkdkhsks tcefe ue afyhr eacrh dc ghjhekfs dc Gjhstrkdkua y acehr eacrh dc
ghjhekfs dc@kikdus y dcJfgth`fgkjjus "Wakts* 0>>6+%
Icugbtcr "0>>3+* ceghetr quc ce dctcrakefdhs ahaceths dc jf vkdf dcj
fekafj ifgthrcs cxocehs dkvcrshs "gfa`khs dc fjkacetfgke* keicggkhecs y
pfrfsktksahs* trftfakceths ghe fetk`ktkghs* ctg%+ prhvhgfe jf rupturf dcj cqukjk`rkh
ketcstkefj y thdh cj skstcaf dkocstkvh sc vc ficgtfdh ce afyhr h acehr orfdh% Cj
prkacr sethaf dc cstf rupturf cs jf dkfrrcf* cxprcske dc jf dc`kjkdfd dc jfs dcicesfs
ketcstkefjcs quc phsk`kjktf f jhs oracecs pftocehs kapjfetfrsc* fdbcrkrsc y
prhjkicrfr ce jfs gjujfs cpktcjkfjcs dcj ketcstkeh%
0%;% CRGJSWKE GHA^CTKTKYF
Wcoe Gcrvfetcs "0>6>+* jhs acgfeksahs dc fggke prhpucsths pfrf cj
iceaceh dc Cxgjuske Ghapctktkvf she jhs skoukcetcs=
f+ Iskgh= ghapctcegkf phr jhs juofrcs dc ueke fj cpktcjkh% Jf fdbcrcegkf dc jf ijhrfehrafj phr acdkh dc jcgtkefs auy cspcgikgfs cs dc kaphrtfegkf cscegkfj* jfs
`fgtcrkfs fefcrh`kfs sc fdbkcrce ikracacetc f jfs supcrikgkcs aughsfs y phscce
ikjfaceths quc pfrcgce pcectrfr cj cpktcjkh dc supcrikgkc% Cstf gfpf bhahoecf dc
dkicrcetcs fefcrh`khs grcf uef `frrcrf iskgf dc fjtf gheskstcegkf* quc cvktf quc jfs
`fgtcrkfs cetcrh!pftocefs sc fdbkcrfe fj rcvcstkakceth cpktcjkfj%
`+ @khjokgh= cj grcgkakceth fefcrh`kh grcf ue b`ktft ghe `fmf tceske dc hxoceh y
ue akgrhfa`kcetc dc cxgjuske durfdcrh quc cs dcsifvhrf`jc pfrf cj grcgkakceth dc
cetcrh`fgtcrkfs akgrh fcrhijkgfs* ghah Wfjahecjjf sp%
-
7/23/2019 EVALUACIN DEL EFECTO DE UN PROBITICO NATIVO ELABORADOEN BASE A Lactobacillus acidophilus y Bacillus su
30/105
69
g+ Vuakgh= sc ghehgc `kce quc jf rcduggke dcj pB dc`kdh f jf prhduggke dc
gkdhs hroekghs "gkdhs orfshs vhjtkjcs ghah cj gkdh jgtkgh y gkdh prhpkekgh+
dc dctcrakefdhs oruphs `fgtcrkfehs phr cmcapjh jfgth`fgkjhs kebk`c cetcrhpftocehs
ghah Wfjahecjjf sp% yC% ghjk%
d+ @khquakgh= Augbhs akgrhhrofeksahs ketcstkefjcs ghahJfgth`fgkjjus spp% y C%
ghjk prhdugce sustfegkfs kebk`kdhrfs* dcehakefdfs* `fgtcrkhgkefs* quc she dc
efturfjczf fetkakgrh`kfef%
c+ Eutrkgkhefj= cstudkhs ghe gujtkvhs dc cxgjuske ke vktrh sc bfe dcahstrfdh quc
fefcrh`khs y Wfjahecjjf sp% ghapktce phr fakehgkdhs cscegkfjcs y fzgfrcs%
0%6>% KETCPFGGKE DCJ WKWTCAF KEASEHJOKGH [ CJ TPFGTHOFWTPHKETCWTKEFJ
Fprhxkafdfacetc cj ?3# dc jfs gjujfs keauektfrkfs dcj fvc "7# dcj pcsh
vkvh+ cste jhgfjkzfdfs ce cj ketcstkeh dcjofdh* fshgkfdfs fj tcmkdh jkeihkdc%
Ce jfs fvcs jf `hjsf dc If`rkgkh y cj tkah* she jhs rofehs jkeihkdcs prkafrkhs< y cj
`fzh* dkvcrtgujh dc Acglcj* ojedujf dc Bfrdcrkfe* pjfgfs dc ^cycr y faodfjfs she
jhs scguedfrkhs% F jf cgjhske* cj skstcaf keauektfrkh cs keafdurh y cvhjugkhef asjcetfacetc quc cj skstcaf dkocstkvh fetcrkhracetc dcsgrkth* phr jh quc durfetc jf
prkacrf scafef dc vkdf cj phjjkth dcpcedc ce orfe acdkdf dcj fa`kcetc ce quc sc
cegucetrf% Jf prcske ocetkgf sh`rc vcjhgkdfd dc grcgkakceth* tkcec ue kapfgth
ecoftkvh sh`rc cj skstcaf keauektfrkh "Hrtkz* 0>>9+%
Cj skstcaf keauec dkocstkvh sc gheskdcrf ghah ueh dc jhs as orfedcs fj scr cj
sktkh quc ghetkcec afyhr gfetkdfd dc gjujfs keauehjokgfs hrofekzfdfs cedkicrcetcs cstrugturfs "^jfgfs dc ^cycr* Theskjfs Gcgfjcs* Dkvcrtgujh dc Acglcj*
Theskjf Cshiokgf* Tcmkdh Jkeihkdc Fshgkfdh f Aughsfs* @hjsf dc If`rkgkh+% ^hr
cjjh* cj cstudkh dcj skstcaf keauec dkocstkvh ce jfs fvcs rcprcscetf uef hphrtuekdfd
pfrf fpjkgfr cstc ghehgkakceth ce orfemfs ghacrgkfjcs* bcgbh ghe cj gufj scr phsk`jc
hptkakzfr sus iuegkhecs y jhorfr uef acmhrf prhdugtkvf "Oacz* 0>6>+%
-
7/23/2019 EVALUACIN DEL EFECTO DE UN PROBITICO NATIVO ELABORADOEN BASE A Lactobacillus acidophilus y Bacillus su
31/105
6?
0%6>%6 ^rhpkcdfdcs dcj Augus dcj Ketcstkeh y dc jf @frrcrf Aughsf
Cj augus ghestktuyc uef `frrcrf auy scjcgtkvf* cscegkfj pfrf prhtcocr jf
aughsf dc jfs scgrcgkhecs dkocstkvfs* dc jhs pftocehs y dc jfs forcskhecs
ikskghquakgfs% Jhs akgrhhrofeksahs dcj buspcd y jfs keauehojh`ujkefs sc
cegucetrfe ketcorfdhs ce cj augus% Fdcas* jf rcehvfgke ghetkeuf dcj augus y dc
jf `frrcrf iskgf grcfdf phr jf gfpf dc aughskdfd* prcvkcec jf ikmfgke dc
akgrhhrofeksahs pftocehs f jf supcrikgkc cpktcjkfj% Fs* jhs gfa`khs dc jfs
prhpkcdfdcs ikskghquakgfs dcj augus* gfusfdfs phr ifgthrcs cxtcrehs fj juace
ketcstkefj h phr vf dc jf aughsf pcr sc pucdce ficgtfr f jf rcskstcegkf f jfs
keicggkhecs y fjtcrfr jf f`shrgke dc eutrkcetcs "Wakts* 0>>6+%
0%66% JHW PH@KTKGHW
Se prh`ktkgh sc dcikec ghah ue supjcaceth fjkacetkgkh akgrh`kfeh vkvh quc
ficgtf dc ihraf `ceikgf fj fekafj buspcd acdkfetc cj acmhrfakceth dc su
cqukjk`rkh akgrh`kfeh ketcstkefj% Jhs prh`ktkghs sc pucdce usfr pfrf ahdujfr jfs
`fgtcrkfs dcj ketcstkeh% Jfs prcpfrfgkhecs ghacrgkfjcs dc prh`ktkghs pucdce scr dcgcpf ekgf h ajtkpjc y tfa`ke ghah uef aczgjf dc vfrkfs cspcgkcs "aujtkcspcgkcs+
dc `fgtcrkfs% Jhs prhdugths aujtkcspcgkcs pucdce tcecr cj `cecikgkh dc scr cikgfgcs
ghetrf uef ofaf as fapjkf dc ghedkgkhecs dcj tu`h dkocstkvh "[cofek* 0>6>+%
Wcoe Jyhes "6;;?+ gktfdh phr Akjkfe "0>>3+* jhs prh`ktkghs she prhdugths
efturfjcs quc utkjkzfdhs ghah prhahthrcs dcj grcgkakceth ce jhs fekafjcs pcraktce
h`tcecr afyhrcs rcedkakceths* as cjcvfdf rcskstcegkf keauehjokgf y rcdugkdfgfetkdfd dc pftocehs ce cj trfgth ofstrhketcstkefj "TOK+% Cstfs `fgtcrkfs
rcprcscetfdfs phr Jfgth`fgkjjus fgkdhpbkjus* Jfgth`fgkjjus `ujofrks*
@kikdh`fgtcrkua `kikdua* @kikdh`fgtcrkua keifetks y htrhs akgrhhrofeksahs
`cecikgkhshs* she jf prkacrf jecf dc dcicesf dcj gucrph ghetrf jhs akgrhhrofeksahs
phtcegkfjacetc dfkehs quc sc kebfjfe h sc keokcrce%
-
7/23/2019 EVALUACIN DEL EFECTO DE UN PROBITICO NATIVO ELABORADOEN BASE A Lactobacillus acidophilus y Bacillus su
32/105
62
0%60% KA^HPTFEGKF DC JHW PH@KTKGHW
Cj pfpcj as kaphrtfetc dc jfs `fgtcrkfs prh`ktkgfs cs fgtufr ce rcskstcegkf ce
ghetrf dc jf ghjhekzfgke dc focetcs cxocehs* pftocehs phtcegkfjcs%
@kikdh`fgtcrkua y Jfgth`fgkjjus she `fgtcrkfs Orfa phsktkvfs prhdugthrfs dc gkdh
jgtkgh* ghestktuycetcs dc uef orfe pfrtc dc jf akgrhijhrf ketcstkefj ce fekafjcs% ^hr
ue akgrhhrofeksah pftoceh ce fggke fgtf ue prh`ktkgh* sk cstc eh cs txkgh h
gfusf ceicracdfd cj prh`ktkgh dc`c scr gfpfz dc rcskstkr jhs gkdhs y jf `kjks* fs
ghah cj prhgcsh dc dkocstke dcj csthafoh dcj fekafj* cj kedkvkduh quc cs gfpfz dc
cstf`jcgcrsc y ghjhekzfr jhs ketcstkehs< cs gufedh cj prh`ktkgh cstf`jcgc jf bf`kjkdfd
dc kebk`kr cj grcgkakceth dc jhs pftocehs%
Jhs prh`ktkghs she gfpfgcs dc prcvcekr jf prhjkicrfgke dc ceicracdfdcs
gfusfdfs phr pftocehs ghah jh she jf Csgbcrkgbkf ghjk y Wfjahecjjf% Csth pucdc
hgurrkr dc dhs ihrafs= ^rkacrh kegrcacetfedh jf rcskstcegkf f keicggkhecs y
ceicracdfdcs keicggkhsfs phr ue fetfoheksah dkrcgth h phr cstkaujfgke dc jf
keauekdfd "kegrcaceth dc jf fgtkvkdfd ifohgtkgf y cjcvfdf scgrcgke dc
Keauehojh`ujkef F "KoF+% Jhs prh`ktkghs cste prhpucsths pfrf cj ush ce fekafjcsy cstf`jcgcr jf sfjud dc jf akgrhijhrf dc jhs ketcstkehs y prcvcekr cj cstf`jcgkakceth
dc `fgtcrkfs pftocefs* pfrf rcstf`jcgcr jf akgrhijhrf `ceikgf fohtfdf phr
fetk`ktkghs y prcvcekr jf rckeicggke phr pftocehs y rcdugkr jhs cicgths dcj cstrs
"Wfjvfdhr y Gruz* 0>>;+%
Ahrceh "0>>7+ gktfdh phr Akjkfe "0>>3+* pjfetcf quc she augbfs jfs `fgtcrkfs
y jcvfdurfs quc sc pucdce usfr dc ihraf `cecikgkhsf pfrf afetcecr uef ijhrfdkocstkvf sfef y ce cqukjk`rkh% Jhs akgrhhrofeksahs as usfdhs she Jfgth`fgkjjus
sp%* Wrcpthghggus ifcggkua* @fgkjjus su`tkjks* @% gcrcus* @% jkgbcekihraks* @%
stcfrhtbcrahpbyjjus y Wfggbfrhaygcs gcrcvkskfc% Jhs Jfgth`fgkjjus grcgce
rpkdfacetc ce cj ketcstkeh she qukzs jhs as ghehgkdhs* sc trftf dc `fgtcrkfs quc
pucdce trfesihrafr jf jfgthsf ce gkdh jgtkgh% Cstc fuaceth dc gkdh jgtkgh
dksakeuyc cj pB ketcstkefj "Ikourf 6+ f uehs ekvcjcs tfe `fmhs fs ghah dksakeuyc jf
supcrvkvcegkf dc akgrhhrofeksahs ghah C% ghjk* Wfjahecjjfs cetrc htrhs%
-
7/23/2019 EVALUACIN DEL EFECTO DE UN PROBITICO NATIVO ELABORADOEN BASE A Lactobacillus acidophilus y Bacillus su
33/105
6;
Cj fgkdh jgtkgh quc prhdugce jfs `fgtcrkfs dcj oecrh Jfgth`fgkjjus y
@kikdh`fgtcrkua fyudfe f ghetrhjfr jfs `fgtcrkfs pftocefs ghah Wfjahecjjfs* C%
ghjk* cetcrktks* fj cstf`jcgcr ue pB `fmh "@htcrh 0>>2+%
Jhs prh`ktkghs prhdugce fgkdh jgtkgh y fgkdh fgtkgh jhs gufjcs grcfe uef
fjtcrfgke dcj pB quc iuegkhefe ghah ue fetksptkgh dcj skstcaf dkocstkvh y fj
aksah tkcaph akekakzf jf prhjkicrfgke dc akgrhhrofeksahs pftocehs* fj ghapctkr
phr eutrkcetcs y fjhmfakceth ce jfs pfrcdcs ketcstkefjcs "Jfstrfs 0>>;+%
0%60%6% Grktcrkhs pfrf ue ^rh ktkgh
Wcoe Efvf "0>>2+ ue prh`ktkgh dc`c rcuekr jfs skoukcetcs gfrfgtcrstkgfs=
Jf scourkdfd `khjokgf* eh dc`ce gfusfr keicggkhecs dc rofehs h dc skstcafs%
Jf gfpfgkdfd dc scr thjcrfdfs phr cj skstcaf keauektfrkh dcj hrofeksah buspcd*
phr jh tfeth* dc`ce scr prcicrk`jcacetc dc prhvcekcegkf ketcstkefj%
Jf gfpfgkdfd dc rcskstkr jf fggke dc jhs gkdhs ostrkghs y dc jfs sfjcs `kjkfrcs
pfrf jjcofr vkvfs ce orfedcs gfetkdfdcs fj ketcstkeh%
Jf gfpfgkdfd dc fdbcrkrsc f jf supcrikgkc dc jf aughsf ketcstkefj y dc ghjhekzfr cj
scoaceth ofstrhketcstkefj%
Jf skecrokf ghe jf akgrhijhrf cedocef ehrafj dcj ketcstkeh
Cj cicgth `frrcrf* cstc trakeh dcikec jf gfpfgkdfd dc prhdugkr sustfegkfs quc
tceofe uef fggke trikgf sh`rc cj cpktcjkh dc jf aughsf ketcstkefj%
Jf gfpfgkdfd dc phtcegkfr jfs dcicesfs keauektfrkfs dcj buspcd%
0%60%0% Acgfeksahs dc Fggke dc jhs ^rh ktkghs
Fjouehs gkdhs cxgrctfdhs phr jhs akgrhhrofeksahs dc jhs prh`ktkghs `fmfe cj
pB ketcstkefj phr dc`fmh dcj ekvcj quc thjcrfe jhs pftocehs%
Cicgth ghapctktkvh quc pucdc scr acdkfdh phr jf hgupfgke dc jhs juofrcs dc
ghjhekzfgke y acmhrf dc jhs acgfeksahs `frrcdhrcs eutrkgkhefjcs%
-
7/23/2019 EVALUACIN DEL EFECTO DE UN PROBITICO NATIVO ELABORADOEN BASE A Lactobacillus acidophilus y Bacillus su
34/105
0>
Gfpfgkdfd dc scgrcgke phr pfrtc dc jhs jfgth`fgkjhs y `fgtcrkfs `ikdfs dc
`fgtcrkhgkefs quc tkcece fapjkh cspcgtrh dc fgtkvkdfd ghah jfgthgkefs*
bcjvctkgkefs* jfgtfgkefs* gurvfgkefs* ekgkefs y kikdhgkefs "^kehs* 0>>?+%
Wcoe @hrke "0>>9+* jf ihraf dc fggke cs=
Dkshgkfgke dcj fgkdh jk`crfedh B, pfrf cj acdkh%
Ahdujfgke dc jf akgrhijhrf ketcstkefj%
Kegrcaceth dcj eacrh dc akgrhhrofeksahs ceikghs=
@kikdh`fgtcrkua* Jfgth`fgkjjus* Cetcrghggus* @fgkjjus%
Pcduggke dcj eacrh dc akgrhhrofeksahs kedcscf jcs=
Wfjahecjjf sp* C% ghjk* Gjhstrkdkua* Wtfpbyjhghggus
Jf akgrhijhrf ketcstkefj cst kevhjugrfdf ce uef fapjkf ofaf dc sugcshs
ikskhjokghs* eutrkgkhefjcs c keauehjokghs* quc pucdce ficgtfr dkrcgtf h
kedkrcgtfacetc jf sfjud y jf prhdugtkvkdfd dc jfs pfrvfdfs ghacrgkfjcs% Jf ph`jfgke
ehrafj dc akgrh`khs ce cj ketcstkeh prhtcoc fj fekafj buspcd dc jhs
akgrhhrofeksahs pftocehs% Tfa`ke sc keihrafrhe quc jfs `fgtcrkfs `ceikgfs "phrcmcapjh*Jfgth`fgkjjus fgkdhpbkjus+ iucrhe gfpfgcs dc suprkakr jhs cicgths
pftocehs dcj Gjhstrkdkua pcrirkeoces ce cj ketcstkeh dcjofdh dc phjjhs dc ceohrdf
acdkfetc jf kebk`kgke dc jf prhjkicrfgke dc jf prhduggke dc thxkefs dc cstc
akgrhhrofeksah% Ce htrh cstudkh* sc h`scrvfrhe quc cjJfgth`fgkjjus sp% fksjfdh dcj
ketcstkeh dcj phjjh prcscetf`f cicgths kebk`kthrkhs sh rc cj grcgkakceth dc jfs
`fgtcrkfs pftocefs* ghah jf Wfjahecjjf yC% ghjk "[cofek* 0>6>+%
0%60%7% @cecikgkhs dc jhs prh`ktkghs ce prhduggke fekafj
Jhs cicgths phtcegkfjcs dc jfs `fgtcrkfs prh`ktkgfs she rcsuakdhs phr
@ceoafrl "6;;9+ gktfdh phr Wfafekcoh y Whsf "0>>0+%
^rhduggke dc eutrkcetcs dc cspcgkfj kaphrtfegkf pfrf jf aughsf ketcstkefj*
tfjcs ghah gkdhs orfshs* pfrtkgujfracetc jhs dc gfdcef ghrtf y fakehgkdhs
ghah= frokekef* ojutfakef y gkstcef%
-
7/23/2019 EVALUACIN DEL EFECTO DE UN PROBITICO NATIVO ELABORADOEN BASE A Lactobacillus acidophilus y Bacillus su
35/105
06
^rhduggke dc akgrheutrkcetcs* cspcgkfjacetc vktfakefs "fjouefs vktfakefs dcj
ghapjcmh @+* fetkhxkdfetcs y fakefs "bkstfakef* 3!BT* pkpcrkdkef* tkrfakef*
gfdfvcrkef* pkrrhjkdkef* foaftkef* cspcrakdkef y putrcsgkef+* augbhs dc jhs
gufjcs she utkjkzfdfs phr thdh cj hrofeksah%
^rcvcegke dcj sh`rcgrcgkakceth dc akgrhhrofeksahs phtcegkfjacetc
pftocehs%
Cstkaujfgke dcj skstcaf dc dcicesf keauehketcstkefj* rcicrkdh ghah skstcaf
dc tcmkdh jkeihkdc fshgkfdh fj trfgth%
Cjkakefgke dc thxkefs y sustfegkfs keecgcsfrkfs dcj juace%
^frtkgkpfgke ce jf rcoujfgke dc iuegkhecs ketcstkefjcs* tfjcs ghah= utkjkzfgke
dc augus* f`shrgke dc eutrkcetcs* ahtkjkdfd ofstrhketcstkefj y ijumh dc sfeorc*
jh gufj hgurrc f trfvs dc jf prhduggke dc gkdhs orfshs dc gfdcefs ghrtfs*
bhrahefs* cezkafs* phjkfakefs y gkthqukekefs y xkdh ektrhsh%
Kaphrtfegkf dcj acgfeksah dc cxgjuske ghapctktkvf% Ce cj Gufdrh 0% fpfrcgc
ue jkstfdh dc jfs `fgtcrkfs gkdhs jgtkgfs usfdhs ghah prh`ktkghs%
Gufdrh 0% Tf`jf dc `fgtcrkfs gkdh jgtkgfs usfdfs ghah prh`ktkghs
Jfgth`fgkjjus Wtrcpthghggus @kikdh`fgtcrkua
J% fgkdhpbkjus W% grcahrks @% `kikdua
J% gfsckW% sfjkvfrkus su`sp%
tbcrahpbkjus@% fdhjcsgcetks
J% dcj`rucglkk su`sp%
`ujofrkgusW% ifcgkua @% fekafjks
J% `rcvks W% dkfgctyjfgtks @% keifetks
J% gcjjh`khsus W% ketcracdkus @% jheoua
Iucetc= Wfafekcoh y Whsf "0>>0+%
Wcoe Afrutf ct fj% "6;;9+ c keihrafdhs phr Akjkfe "0>>3+* csths aksahs
futhrcs ce htrf kevcstkofgke cstudkfrhe cj ush dc ue prh`ktkgh f `fsc dc @fgkjjus
gcrcus "Thyhgcrke+ ce phjjhs dc gc`f% Wuakekstrfrhe 3> y 6>> ao(lo ce jf dkctf y
ghaprh`frhe quc cj pcsh ikefj crf supcrkhr ce 6*3# y 0*6#* ce jhs fekafjcs trftfdhs
rcspcgth fj ghetrhj% Fs aksah* acmhr jf ghevcrske 6*0# y 0#% Jf ahrtfjkdfd iuc
dksakeukdf f 0*?# y 4*3# ghe rcspcgth fj oruph ghetrhj%
-
7/23/2019 EVALUACIN DEL EFECTO DE UN PROBITICO NATIVO ELABORADOEN BASE A Lactobacillus acidophilus y Bacillus su
36/105
00
Ghjke ct fj% "6;;4+ gktfdh phr Akjkfe "0>>3+* cstudkfrhe cj cicgth dcj capjch dc
dhs prh`ktkghs "csphrfs dc @fgkjjus sp% f rfze dc 6>> ppa ghe 6>6> uig(o y uef
aczgjf dc akgrhhrofeksahs jgtkghs* jcvfdurfs y cezkafs dkocstkvfs f rfze dc 6>>
ppa ce dkctfs dc phjjhs dc ceohrdc* fdcas dcj fetk`ktkgh jkghakgkef ue ghetrhj
phsktkvh% Ceghetrfrhe uef acmhrf ce jf ofefegkf dc pcsh% Jf fggke dc jhs dhs
prh`ktkghs eh dkikrk cetrc sk* pcrh sk ghe cj fetk`ktkgh y cj oruph ghetrhj%
0%67% @FGTCPKFW GKDH JGTKGFW
Efvf "0>>2+* acegkhef quc jf gfpfgkdfd dc jfs `fgtcrkfs jgtkgfs pfrf kebk`kr cj
grcgkakceth dc htrhs hrofeksahs ce gujtkvhs akxths bf skdh h`scrvfdf durfetc asdc ?> fhs* jh quc ghaeacetc sc bf jjfafdh fetfoheksah jgtkgh% Jf rcduggke dc
pB y jf utkjkzfgke dc jhs gfr`hbkdrfths dksphek`jcs pfrcgce ghestktukr cj prkegkpfj
acgfeksah dc fetfoheksah akgrh`kfeh% Eh h`stfetc* tfa`ke sc ghehgc quc jfs
`fgtcrkfs jgtkgfs prhdugce fdcas dc gkdhs hroekghs* pcrxkdh dc bkdrhoceh*
rfdkgfjcs jk`rcs* dkfgctkjh* fgctfjdcbdh* ksacrhs D dc jhs fakehgkdhs* fetk`ktkghs
y fgtcrkhgkefs
0%67%6% @fgtcrkfs rhdugthrfs dc gkdh Jgtkgh
Wcoe Mfrfakjjh "0>6>+* jhs prh`ktkghs as capjcfdhs she jfs `fgtcrkfs
gfpfgcs dc prhdugkr gkdh jgtkgh* ghah Jfgth`fgkjjus fgkdhpbkjus*J% gfsck* J%
`ujofrkgus* J% rcutcrkk* J% rbfaehsus* @kikdh`fgtcrkua `rcvc* @% jheoua* @% keifetks*
@% fekafjks* Wtrcpthghggus sfjkvfrkus su`cspcgkc tbcrahpbkjus y Wfggbfrhaygcs
`hujfrdkk%
0%64% GFPFGTCPKWTKGFW DC JFW @FGTCPKFW GKDH JGTKGFW
0%64%6% Gfrfgtcrstkgfs dcJfgth`fgkjjus fgkdhpbkjus
Cj oecrhJfgth`fgkjjus "jfgtks!jcgbc< `fgkjjus!pcquchs `fgkjhs+ sc gfrfgtcrkzf
phr prcscetfr gjujfs ce ihraf dc `fgkjhs jfrohs y cxtcedkdhs* fuequc ghe ircgucegkf
pucdce h`scrvfrsc `fgkjhs ghrths h ghgh!`fgkjhs ghryecihracs% Jfs ghjhekfs dc
-
7/23/2019 EVALUACIN DEL EFECTO DE UN PROBITICO NATIVO ELABORADOEN BASE A Lactobacillus acidophilus y Bacillus su
37/105
07
Jfgth`fgkjjus ce acdkhs sjkdhs she pcqucfs "0!3 aa+* ghevcxfs* sufvcs* ghe
arocecs cetcrhs* hpfgfs y ske pkoaceths% Wjh ce fjouehs gfshs prcscetfe
ghjhrfgke fafrkjjcetf h rhmkzf% Fjouefs cspcgkcs ihrafe ghjhekfs ruohsfs%
Ehrafjacetc eh rcdugce jhs ektrfths* pcrh cstf rcfggke pucdc hgurrkr ce fjouehs
gfshs* gufedh cj pB cst phr cegkaf dc 9*>% Jhs jfgth`fgkjhs eh jkgfe jf ocjftkef ek
dkokcrce jf gfscef* fuequc augbfs gcpfs prhdugce pcqucfs gfetkdfdcs dc
ektroceh shju`jc% Tfaphgh prhdugce kedhj ek sujidrkgh "B0W+% Whe gftfjfsf
ecoftkvhs* pcrh fjouefs gcpfs prhdugce jf cezkaf pscudhgftfjfsf quc dcsghaphec cj
pcrxkdh dc bkdroceh% Whe gkthgrhah ecoftkvhs* phr jf fuscegkf dc phrikrkefs%
Jhs jfgth`fgkjhs grcgce `kce ce acdkhs jkocrfacetc gkdhs* ghe pB kekgkfj dc9*4 ! 4*3% Jf afyhrf dc jfs gcpfs dc Jfgth`fgkjjus she prkegkpfjacetc
fcrhthjcrfetcs< su grcgkakceth ptkah sc fjgfezf `fmh ghedkgkhecs akgrhfcrhijkgfs h
fefcr`kgfs% Jf afyhr pfrtc dc jhs jfgth`fgkjhs she acsikjhs "7> ! 4>G+* ghe ue
jaktc supcrkhr dc 4>G% Fuequc su rfeoh dc tcapcrfturfs pfrf cj grcgkakceth hsgkjf
cetrc 0 y 37G% Jhs akca`rhs dc cstc oecrh trfesihrafe jf ojughsf y jfs bcxhsfs
fjdcbdkgfs skakjfrcs* jhs gfr`hbkdrfths quc prhdugce csths fzgfrcs skapjcs y jhs
fjghbhjcs phjkbkdrhxjkghs ce gkdh jgtkgh phr bhahicracetfgke h `kce* ce gkdhjgtkgh y htrhs prhdugths ikefjcs fdkgkhefjcs ghah gkdh fgtkgh* ctfehj* dkxkdh dc
gfr`heh* gkdh irakgh y gkdh suggekgh "Wfafekcoh y Whsf* 0>>0+%
Wcoe Jfstrfs "0>>;+*Jfgth`fgkjjus fgkdhpbkjus cs uef `fgtcrkf orfa phsktkvf
dhakefetc ce cj ketcstkeh dcjofdh* dhedc sc prhdugc jf afyhr pfrtc dc jf dkocstke*
akcetrfs quc@kikdh`fgtcrkua `kikdua rcskdc ce cj ketcstkeh orucsh dhedc sc prhgcsfe
jhs dcscgbhs pfrf scr cvfgufdhs% CjJ% fgkdhpbkjus f`shr`c jf jfgthsf y jf actf`hjkzfihrafedh gkdh jgtkgh% Durfetc jf dkocstke* tfa`ke fyudf ce jf prhduggke dc
ekfgkef* gkdh ijkgh y vktfakef @9 "pkrkdhxkef+%
Jf prhduggke dc gkdh jgtkgh bfgc quc su fa`kcetc scf gkdh* jh gufj kebk`c
cj grcgkakceth dc `fgtcrkfs pftocefs% Fjouefs cspcgkcs dcJfgth`fgkjjus she usfdfs
kedustrkfjacetc ce jf prhduggke dc yhourt "Ohezfjcs* 6;;?+%
-
7/23/2019 EVALUACIN DEL EFECTO DE UN PROBITICO NATIVO ELABORADOEN BASE A Lactobacillus acidophilus y Bacillus su
38/105
04
0%64%0% Gjfskikgfgke tfxheakgf dcJfgth`fgkjjus
Wcoe Wfafekcoh y Whsf "0>>0+* ce cj trfesgursh dc jhs fhs y ghe cj
dcsfrrhjjh dc jf @khjhof Ahjcgujfr sc bfe capjcfdh vfrkhs grktcrkhs tfxheakghs
pfrf pcricggkhefr jf phskgke tfxheakgf dcj oecrh Jfgth`fgkjjus ce pfrtkgujfr y dc
jfs `fgtcrkfs gkdh jgtkgfs ce ocecrfj% Cetrc csths grktcrkhs pudkcrfe gktfrsc jhs
skoukcetcs=
Dctcrakefgke dc hjkoheugjctkdhs dcj ghcikgkcetc dc scdkacetfgke "69W+ dcj
rPEF "PEF rk`hshafj+%
Cstudkhs scrhjokghs quc kevhjugrfe fetksucrhs ghetrf cezkafs ajkgfs* dcj tkphdc jf irugthsf!6*9!dkihsifth fjdhjfsf y dc jf ojkgcrfjdcbkdh!7!ihsifth
dcsbkdrhocefsf dc vfrkfs `fgtcrkfs gkdh jgtkgfs y dc fjouefs `fgtcrkfs
fcr`kgfs y fefcr`kgfs%
^hrgcetfmc ahjfr dc Oufekef,Gkthgkef dcj FDE%
Ekvcj dc bhahjhof FDE(FDE* phgh skoekikgftkvh cetrc jf afyhrf dc jfs
cspcgkcs%
Bk`rkdkzfgke FPE( FDE%
0%64%7% Gfrfgtcrstkgfs dc@fgkjjus su`tkjks
@fgkjjus su`tkjks cs uef `fgtcrkf Orfa phsktkvf* fcrh`kh ifgujtftkvh
ghaeacetc ceghetrfdf ce cj sucjh% Akca`rh dcj oecrh@fgkjjus*@% su`tkjks tkcec jf
bf`kjkdfd pfrf ihrafr uef rcskstcetc cedhsphrf prhtcgthrf* pcraktkcedh fj hrofeksah
thjcrfr ghedkgkhecs fa`kcetfjacetc cxtrcafs "Jfstrfs 0>>;+%
Wcoe Akjkfe "0>>3+* htrhs dc jhs cjcaceths quc gfrfgtcrkzf f jhs @fgkjjus sp%
cs jf prhduggke dc cezkafs bkdrhjtkgfs quc fyudfe f acmhrfr jf utkjkzfgke dc jhs
fjkaceths% Dcetrh dc cstfs sc cegucetrfe jfs prhtcfsfs* fakjfsfs y jfs ojkghskdfsfs
quc dcsghaphece jfs ghapjcmfs ahjgujfs dc jhs fjkaceths y jfs trfesihrafe ce
eutrkcetcs as skapjcs% Csths ghapucsths she f`shr`kdhs as rpkdfacetc phr cj
fekafj h pucdce scr capjcfdhs phr htrfs `fgtcrkfs `cecikgkhsfs pfrf cj
cstf`jcgkakceth dc uef akgrhijhrf ketcstkefj `fjfegcfdf% Cj capjch dc jfs `fgtcrkfs
-
7/23/2019 EVALUACIN DEL EFECTO DE UN PROBITICO NATIVO ELABORADOEN BASE A Lactobacillus acidophilus y Bacillus su
39/105
03
dcj oecrh @fgkjjus y sus cedhsphrfs tfa`ke vkcec dfdh phr su gfpfgkdfd dc
prhduggke dc cezkafs* cstfs fdcas dc acmhrfr jf dkocstke ce cj bhspcdcrh* she
gfpfgcs dc kebk`kr cj grcgkakceth akgrh`kfeh dc `fgtcrkfs dfkefs%
0%64%4% Gjfskikgfgke Tfxheakgf dc Oecrh@fgkjjus
Gufdrh 7% Tf`jf sh`rc jf gjfskikgfgke tfxheakgf dcj oecrh@fgkjjus
Pckeh Ikrakgutfc
Ikjua Cedhsphrh`fgtcrkf
Gjfsc @fgkjjk
Hrdce @fgkjjkfjcs
Ifakjkf @fgkjjkfgcfc
Ocecrh @fgkjjus
Cspcgkc su`tkjks
E% gkcetikgh @fgkjjus su`tkjks
Iucetc= Ofje "0>>?+%
0%64%3% Gfrfgtcrstkgfs dc@kikdh`fgtcrkua
Bfrtcakel ct fj% "6;;?+ gktfdh phr Mfrfakjjh "0>6>+* jfs `kikdh`fgtcrkfs she
`fgtcrkfs fefcr`kgfs Orfa phsktkvfs* quc bf`ktfe prkegkpfjacetc ce cj ketcstkeh
dcjofdh* bf`ktfetcs ehrafjcs dcj TOK tfeth dcj bha`rc* ghah dc jhs fekafjcs% Whe
`fgkjhs h ghghs eh atkjcs* fefcrh`khs cstrkgths* ghe ihrafs quc dcpcedce dc jf
cspcgkc f jf quc pcrtceczgfe% Pcprcscetfe ueh dc jhs afyhrcs oruphs dc `fgtcrkfs
ketcstkefjcs y sc utkjkzfe prkegkpfjacetc ghah ijhrf prh`ktkgf ce prhdugths jgtchs%
0%63% @FGTCPKHGKEFW
Jfs `fgtcrkhgkefs sc dcikece ghah prhtcefs y pptkdhs `khjokgfacetc fgtkvhs*
quc tkcece prhpkcdfdcs fgtcrkgkdfs ghetrf htrfs cspcgkcs cstrcgbfacetc rcjfgkhefdfs*
akca`rhs dc jf aksaf cspcgkc h cspcgkcs auy rcjfgkhefdfs ghe jf gcpf prhdugthrf%
Wke ca`froh* rcgkcetcacetc cstc ghegcpth sc bf ahdkikgfdh* yf quc sc bf ceghetrfdh
-
7/23/2019 EVALUACIN DEL EFECTO DE UN PROBITICO NATIVO ELABORADOEN BASE A Lactobacillus acidophilus y Bacillus su
40/105
09
tfa`ke fggkhecs `fgtcrkgkdfs ghetrf gcpfs dkstfegkfdfs ikjhocetkgfacetc dc jf gcpf
prhdugthrf "Dhjz* 0>>>+%
Jfs `fgtcrkhgkefs* she dcrkvfdhs dcj actf`hjksah prkegkpfjacetc dc fjouefs
`fgtcrkfs gkdh jgtkgfs "@FJ+* ghe iuegke fetkakgrh`kfef* dc efturfjczf pcptdkgf*
sketctkzfdfs rk`hshafjacetc y quc ficgtfe f `fgtcrkfs rcjfgkhefdfs ghe jfs quc jfs
prhdugce% Wc bf ghaprh`fdh quc pucdce fgtufr sh`rc `fgtcrkfs pftocefs*
cspcgkfjacetc ce Orfa phsktkvfs y ce fjouefs Orfa ecoftkvfs% Jfs `fgtcrkhgkefs bfe
skdh ceghetrfdfs ce gfsk thdfs jfs cspcgkcs `fgtcrkfefs fgkdh jgtkgfs cxfakefdfs
bfstf jf icgbf* y fe dcetrh dc uef cspcgkc phdrfe scr prhdugkdfs dkicrcetcs tkphs dc
`fgtcrkhgkefs "Mfrfakjjh* 0>6>+%
0%63%6% ^rhduggke dc @fgtcrkhgkefs
Fdkgkhefjacetc* augbhs dc jhs akgrhhrofeksahs prhdugthrcs dc `fgtcrkhgkefs
she* f su vcz* prh`ktkghs% Jf ehgke dc prh`khsks fjudc* ce ocecrfj* fj ghemueth dc
cicgths ikskhjokghs quc* vkegujfdhs f jhs `fjfegcs akgrh`kfehs dcj trfgth ketcstkefj*
rcsujtfe ifvhrf`jcs pfrf jf cetkdfd `khjokgf bhspcdfetc% Wc trftf dc ue ghegcpthrcjftkvfacetc dkiush* quc sc bf rcjfgkhefdh sh`rc thdh ghe jf acmhrf dc jf rcskstcegkf
f jfs ceicracdfdcs phr cstkaujfgke dc jfs dcicesfs efturfjcs* y quc pucdc kapjkgfr
acgfeksahs dc efturfjczf `fstfetc bctcrhoecf% Cetrc cjjhs sc gktfe ghe ircgucegkf
ske dctfjjcs ghegrcths jf ghapctcegkf ghe akgrhhrofeksahs pftocehs phr eutrkcetcs
jkaktfetcs h phr pueths dc fdbcrcegkf f jfs aughsfs* jf prhduggke dc sustfegkfs
kebk`kdhrfs dc cstfs cspcgkcs y jf fgtkvfgke dc jf rcspucstf keauektfrkf% Jfs
`fgtcrkhgkefs as ghehgkdfs she ske dudf jfs ekgkefs "jfetk`ktkghs dc Jfgthghggusjfgtks+* pcrh ce cstrcgbf rcjfgke ghe cjjfs sc cegucetrfe htrhs jfetk`ktkghs ghah
su`tkjkef* cstfikjhghggkef* "^fstrfef* 0>>4+%
Wfafekcoh y Whsf "0>>0+* fikrafe quc cetrc jf vfrkcdfd dc sustfegkfs
fetkakgrh`kfefs prhdugkdfs phr jfs `fgtcrkfs gkdh!jgtkgfs sc cegucetrfe jfs
`fgtcrkhgkefs* prhtcefs `fgtcrkgkdfs quc kebk`ce cspcgkcs cstrcgbfacetc rcjfgkhefdfs
ghe cj gujtkvh prhdugthr% Ghah cmcapjh dc cstfs sustfegkfs pucdce gktfrsc jfs quc sc
bfe kdcetkikgfdh y gfrfgtcrkzfdh=
-
7/23/2019 EVALUACIN DEL EFECTO DE UN PROBITICO NATIVO ELABORADOEN BASE A Lactobacillus acidophilus y Bacillus su
41/105
0?
Jfgtfgke @ y I
Bcjvctkgke Y!620;
Icracetkgke
Wflfgke F* A y ^
Jfgtkgkefs F y @
Jfgthgke W
Jfgthgke J^0?
^jfetfrkgke @E
@fvfrkgke AE
^jfetfgke @
0%63%0% Acgfeksahs dc Fggke dc jfs @fgtcrkhgkefs
Mfrfakjjh "0>6>+* acegkhef cj acgfeksah dc fggke prhpucsth pfrf jfs
`fgtcrkhgkefs cs uef ueke kekgkfj f jf aca`rfef `fgtcrkfef phr ftrfggke
cjcgtrhsttkgf cetrc jhs jpkdhs gfrofdhs ecoftkvfacetc y jfs `fgtcrkhgkefs ghe su
gfrof ectf phsktkvf jhgfjkzfdf iuedfacetfjacetc ce ueh dc jhs cxtrcahs% Jucoh sc
prhdugc jf kescrgke dc jf `fgtcrkhgkef ce jf `kgfpf jkpdkgf* ce cj gfsh dc jf ekgkef
cstf kescrgke sc rcfjkzf phr su cxtrcah E!tcrakefj% Fs sc ihrafe phrhs ce jf
aca`rfef* jf gufj qucdf pcracf`kjkzfdf* jf gjujf capkczf f pcrdcr khecs y
actf`hjkths iuedfacetfjcs pfrf su supcrvkvcegkf y cvcetufjacetc sc prhdugc jf
aucrtc dc jf `fgtcrkf%
0%69% KETCPFGGKE DC JHW ^PH@KTKGHW GHE JF AFTCPKF
HPOEKGF [ CJKAKEFGKE DC AFJHW HJHPCW
Cj CA "akgrhhrofeksahs cikgfgcs+ bf skdh fapjkfacetc utkjkzfdh ce cj scgthr
forhpcgufrkh tfeth ce sucjhs y gujtkvhs ghah ce prhduggke fekafj* trftfakceth dc
rcskduhs hroekghs y foufs rcskdufjcs* rcduggke drstkgf dc pjfofs "ahsgfs+*
cjkakefgke dc hjhrcs ahjcsths prhdugkdhs phr jf dcsghaphskgke dc cxgrctfs y
hrkef% Jhs fjths vhjacecs dc dcscgbhs fekafjcs "cxgrctfs y hrkef+ quc sc afecmfe
ce jfs kestfjfgkhecs fvghjfs* bf trfdh ghah ghescgucegkf ue kegrcaceth dc ofscsfahekfgfjcs y sujiurhshs dcetrh y iucrf dc jfs kestfjfgkhecs quc ficgtfe tfeth f jhs
-
7/23/2019 EVALUACIN DEL EFECTO DE UN PROBITICO NATIVO ELABORADOEN BASE A Lactobacillus acidophilus y Bacillus su
42/105
02
hpcrfrkhs ghah f jhs aksahs fekafjcs< grcfedh ue fa`kcetc fjtfacetc ghetfakefdh*
ocecrfdhr dc hjhrcs hiceskvhs y uef fjtf ph`jfgke dc ahsgfs quc ficgtfe fdcas f
jfs ghauekdfdcs vcgkefs% Jfs fspcrskhecs dc CA f jf gfaf c kestfjfgkhecs `usgfe
cstf`jcgcr jfs ph`jfgkhecs dc akgrhhrofeksahs `ceikghs ce jfs cxgrctfs* kapkdkcedh
jf prhjkicrfgke dc htrhs akgrhhrofeksahs quc pudrce jf aftcrkf hroekgf% Dc cstf
afecrf cj CA phr icracetfgke dcj aftcrkfj rcdugc jf ocecrfgke dc afjhs hjhrcs y
jf prcscegkf dc kescgths pjfof%
@fgtcrkfs Ihthskettkgfs h ihthtrikgfs "Pbhdhpscudhahefs spp+= Cs ue oruph
dc akgrhhrofeksahs futtrhihs c kedcpcedkcetcs y futhsuikgkcetcs* jhs gufjcs
sketctkzfe sustfegkfs tkjcs f pfrtkr dc jfs scgrcgkhecs dc jfs rfgcs* aftcrkf hroekgfy(h ofscs ehgkvhs "Cm% Fahefgh* sujiurh dc bkdroceh* actfeh+* usfedh jf juz shjfr
y cj gfjhr dcj sucjh ghah iucetcs dc cecrof% Jfs sustfegkfs sketctkzfdfs ghaprcedce
fakehgkdhs* gkdhs eugjcghs* sustfegkfs `khfgtkvfs y fzgfrcs% Csths actf`hjkths
she f`shr`kdhs dkrcgtfacetc phr cjjfs* y fgtfe tfa`ke ghah sustrfth pfrf
kegrcacetfr jf ph`jfgke dc htrhs akgrhhrofeksahs `ceikghs "Wfjofdh* 0>6>+%
-
7/23/2019 EVALUACIN DEL EFECTO DE UN PROBITICO NATIVO ELABORADOEN BASE A Lactobacillus acidophilus y Bacillus su
43/105
0;
KKK% AFTCPKFJCW [ ATHDHW
7%6% GFPFGTCPWTKGFW DCJ GFA^H CR^CPKACETFJ
7%6%6% S`kgfgke hjtkgf
Cj cesfyh dc kevcstkofgke sc rcfjkz ce jf Orfemf Fvghjf jf Thjktf* Ketcorfdh
dc jf Caprcsf ^rhefgf* ^frrhqukf Juz dc Farkgf* ^rhvkegkf Wfeth Dhakeoh dc jhs
Tsgbkjfs* la ? dc jf Yf Wfeth Dhakeoh!Vucvcdh afroce kzqukcrdh* gkegh
lkjactrhs vf f jf Pcihraf%
7%6%0% S`kgfgke Ochorikgf
Ghhrdcefdfs STA= >> 0> 234/ Wur ?; 67 360/ Hcstc
Ikourf 7% Grhquks dc u`kgfgke dcj rcf cxpcrkacetfj%
7%6%7% S`kgfgke Cghjokgf
Wcoe cj dkforfaf dc ]hefs dc Ykdf dc J% Bhjdrkdoc jf zhef dc cstudkh
ghrrcsphedc f @hsquc Bacdh Trhpkgfj "`b T+"Gffdfs* J% 6;27+
Fjtktud = 993 asea% Tcapcrfturf = 62 ! 02 hG
E
-
7/23/2019 EVALUACIN DEL EFECTO DE UN PROBITICO NATIVO ELABORADOEN BASE A Lactobacillus acidophilus y Bacillus su
44/105
7>
^rcgkpktfgke = 69>> aa(fh
7%0% AFTCPKFJCW
7%0%6% Kesuahs
3;23 ^hjjhs Phss 7>2
93 jktrhs dc prh`ktkgh eftkvh
6 lkjh dc prh`ktkgh ghacrgkfj
02>00 lkjhs dc fjkaceth `fjfegcfdh ^PHEFGF
Yfguefs "9>>> dhsks dc Ecwgfstjc ! Gjhec 7>* 9>>> dhsks dc @rhequktks
K@B 60> y 9>>> dhsks "Oua`hrh @urskec+
9 lkjhs dc Yktfakef "vktfjkzfdhr fvghjf+
66 jktrhs dc gjhrh
4 jktrhs dc ecutrfjkzfetc dc fouf
6 lkjh dc jcgbc ce phjvh
6 lkt dc rcfgtkvh pfrf pB y gjhrh
6 ofje dc GKD!0>
2 jktrhs dc yhdh
3 jktrhs dc vkrulkjj
9> lkjhs dc gfj vkvf
7%0%0% Cqukphs
40 ghacdcrhs tu`ujfrcs dc 60 lo
06 ghacdcrhs kegkfjcs @C@ 06 `c`cdcrhs afeufjcs dc ofje
06 c`cdcrhs futhatkghs
9 grkfdhrfs f ofs
0> tfequcs dc ofs kedustrkfj dc 63 lo
6 rhjjh dc ghrtkefs "0%2a x 3>a+
6 rhjjh dc ghrtkef "6a x 3>a+
6 tcraactrh 6 gafrf ihthorikgf
-
7/23/2019 EVALUACIN DEL EFECTO DE UN PROBITICO NATIVO ELABORADOEN BASE A Lactobacillus acidophilus y Bacillus su
45/105
76
@fjfezf cjcgtrekgf
7%0%7% Kestruaceths
7 Pcokstrhs dc gfaph
6 Jk`rctf dc gfaph
0 Csicrhs
7%0%4% Bcrrfakcetfs
6 afgbctc
6 ^fjf rcdhedf
02 cstfgfs
7 rhjjhs dc fjfa`rc '62
6 rhjjh dc afjjf pjstkgf dc 6%2 a x 3> a
7 `fjdcs pjstkghs dc gfpfgkdfd 0> jktrhs
7%0%3% Aftcrkfjcs y cqukphs dc jf`hrfthrkh
Gufdrh 4% Tf`jf dc cqukphs utkjkzfdhs ce jf`hrfthrkh
Cqukph Sekdfd GfetkdfdCstuif fgtcrkhjokgf S 6Kegu`fdhrf S 6Akgrhsghpkh ghapucsth S 6Gafrf ijumh jfakefr S 6@fjfezf fefjtkgf S 6Ghgkectf S 6
Pcirkocrfdhrf S 6
Gufdrh 3% Tf`jf dc aftcrkfjcs y rcfgtkvhs utkjkzfdhs ce jf`hrfthrkh
Cqukph Sekdfd GfetkdfdGfmfs pctrk S 2>Tcst cezkatkgh S 6^hrtf h`mcths S 6>Tu`hs dc cesfyh S 0>^kpctf S 0Yfshs dc prcgkpktfgke "3>> aj+ S 4
Cjceacycr "3> aj+ S 4Fouf dcstkjfdf J 4>
-
7/23/2019 EVALUACIN DEL EFECTO DE UN PROBITICO NATIVO ELABORADOEN BASE A Lactobacillus acidophilus y Bacillus su
46/105
70
Fofr APW Or 3>>Gfjdh APW Or 3>>Fjghbhj kedustrkfj J 6Fjghbhj fetksptkgh J 7
Wucrh ikskhjokgh J 6Afsgfrkjjfs S 4Oufetcs qukrrokghs S 7^jfgfs ^ctrkikja7 A S 6^kgctf S 6Acgbcrhs S 7
7%7% ACTHDHJHOF
7%7%6% IFWC DC JF@HPFTHPKH
7%7%6%6% Pcghjcggke dc aucstrf
Wc scjcggkhe fj fzfr ue phjjh dc ceohrdc Phss 7>2* pfrf h`tcecr jhs
akgrhhrofeksahs ghe jhs gufjcs sc cjf`hr cj prh`ktkgh eftkvh% Dc cstf fvc sc
scjcggkhe cj skstcaf dkocstkvh quc gheihra jf pfrtc acdkf dcj jche y gkcohs
"Fecxh 9+%
7%7%6%0% Wkca`rf ce jhs acdkhs dc gujtkvh
Wc tha ue rfspfdh dc jf aughsf dcj jche y dc jhs gkcohs rcspcgtkvfacetc*
pfrf scr ghjhgfdh ce 3 aj dc sucrh ikskhjokgh y sc prhgcdk f jf skca`rf ce gfmfs
pctrk ghetcekcedh acdkhs cspcgikghs pfrf cj dcsfrrhjjh dc @fgtcrkfs Fgkdhjgtkgfs*
Fofr y Gfjdh APW "Fecxh 6>+% Jucoh sc ghjhgfrhe ce jf kegu`fdhrf f 02hG phr 42
bhrfs pfrfJfgth`fgkjjus y ?0 bhrfs pfrf@fgkjjus%
7%7%6%7% ^urkikgfgke dc ghjhekfs
Wc prhgcdk f purkikgfr jfs gcpfs sca`rfdfs quc prcscetf`fe gfrfgtcrstkgfs dcj
oecrh Jfgth`fgkjjus "@hrdc uekihrac y jksh* Ghjhekfs orfedcs y dcesfs+ y @fgkjjus
"@hrdcs krrcoujfrcs* Ghjhr `jfegh f grcaf* Puohsfs* Ghjhekfs orfedcs+
-
7/23/2019 EVALUACIN DEL EFECTO DE UN PROBITICO NATIVO ELABORADOEN BASE A Lactobacillus acidophilus y Bacillus su
47/105
77
7%7%6%4% Kdcetkikgfgke dc gcpfs eftkvfs
^frf jf kdcetkikgfgke sc utkjkzfrhe gfrfgtcrstkgfs Ahrihjokgfs* ^ruc`fs
@khquakgfs y Ahjcgujfrcs%
7%7%6%3% Ghegcetrfgke dc `fgtcrkfs
^frf acdkr jf ghegcetrfgke dc jfs `fgtcrkfs sc utkjkz cj athdh pfrf
Grcgkakceth dc @fgtcrkfs gkdh jgtkgfs ce ^jfgfs ^ctrkikja 7A y pfrfjcjfacetc sc
cevkfrhe aucstrfs f ue jf`hrfthrkh cspcgkfjkzfdh pfrf dctcrakefr jf ghegcetrfgke%
7%7%6%9% Ihraujfgke dcj prh`ktkgh
Wc scjcggkhe uef gfmf pctrk purkikgfdf dc gfdf `fgtcrkf%
Wc tha uef aucstrf dc gfdf gfmf pctrk y sc kehguj ce cj acdkh dc gujtkvh
Gfjdh APW* pfrf h`tcecr uef shjugke afdrc dcj prh`ktkgh eftkvh "WA^E+ y
sc ghjhg ce jf kegu`fdhrf f 02>
G phr 42 bhrfs% ^frf jf fgtkvfgke dcj prh`ktkgh eftkvh sc tha uef aucstrf dc 6> aj dc jf
shjugke afdrc ghe uef pkpctf pfrf scr kehgujfdf ce uef shjugke dc fouf as
acjfzf%
Dc jf aksaf afecrf sc fgtkvh cj prh`ktkgh ghacrgkfj%
7%7%0% DKWCH CR^CPKACETFJ
7%7%0%6% Ifgthrcs f prh`fr
f+ Tkph y Dhsks dc prh`ktkghs
T>= > aj(j fouf
T6= ^rh`ktkgh eftkvh= 6*3< 7*>< 4*3 aj
T0= ^rh`ktkgh ghacrgkfj= 6*3< 7*>< 4*3 aj
`+ Jhtc
-
7/23/2019 EVALUACIN DEL EFECTO DE UN PROBITICO NATIVO ELABORADOEN BASE A Lactobacillus acidophilus y Bacillus su
48/105
74
7%7%0%0% Trftfakceths f ghapfrfr
^frf cvfjufr cj cicgth dc ue prh ktkgh eftkvh cjf`hrfdh ce `fsc f
Jfgth`fgkjjus fgkdhpbkjus y @fgkjjus su`tkjks ce phjjhs @rhkjcr Phss!7>2 ce Wfeth
Dhakeoh dc jhs Tsgbkjfs sc prh` jhs skoukcetcs trftfakceths%
TPFTFAKCETH GDKOH DCWGPK^GKET6 ^e6 6*3 aj prh`ktkgh eftkvh(j foufT0 ^e0 7*> aj prh`ktkgh eftkvh(j foufT7 ^e7 4*3 aj prh`ktkgh eftkvh(j foufT4 ^g6 6*3 aj prh`ktkgh ghacrgkfj(j foufT3 ^g0 7*> aj prh`ktkgh ghacrgkfj(j foufT9 ^g7 4*3 aj prh`ktkgh ghacrgkfj(j foufT? Wp Tcstkoh
7%7%0%7% Tkph dc dksch
Wc fpjkg ue Dksch dc @jhqucs Ghapjcths fj Fzfr "D@GF+% Fdkgkhefjacetc
sc rcfjkz ue fejksks dc vfrkfezf "FDCYF+ pfrf acdkr jhs gfa`khs f trfvs dcj
tkcaph%
7%7%0%4% H`scrvfgkhecs
Jf kevcstkofgke ghest dc trcs `jhqucs% Gfdf `jhquc iuc ue gkgjh prhdugtkvh%
7%7%0%3% Gfrfgtcrstkgfs dc jf SC
Eacrh dc SC = 06rcf Thtfj = 0;? a0
rcf tkj = 076 a0
Ihraf = Pcgtfeoujfr Jfroh = 66 aFegbh = 7 a
Eacrh thtfj dc fvcs = 3;23
Eacrh dc fvcs phr `jhquc = 6;;3
Eacrh dc fvcs phr trftfakceth = 023
-
7/23/2019 EVALUACIN DEL EFECTO DE UN PROBITICO NATIVO ELABORADOEN BASE A Lactobacillus acidophilus y Bacillus su
49/105
73
Eacrh dc fvcs phr rcpctkgke = ;3
7%7%7% Fejksks cstfdstkgh
7%7%7%6% Csqucaf dcj fejksks dc vfrkfezf
Wc utkjkz ue D@GF* ghe skctc trftfakceths* trcs `jhqucs ce dkicrcetcs phgfs%
Gufdrh 9% Csqucaf dcj fejksks dc vfrkfezf pfrf jhs ifgthrcs ce cstudkh
Iucetc dc Yfrkfgke Oj
Trftfakceth 9Tcstkoh vs rcsth 6
^ eftkvh vs ghacrgkfj 6
^ eftkvh jkecfj 6
^ eftkvh gufdrftkgf 6
^ ghacrgkfj jkecfj 6
^ ghacrgkfj gufdrftkgf 6
Jhtc 0
Trftfakceth-jhtc 60
Crrhr cxpcrkacetfj 64Crrhr dc aucstrch 40
Thtfj 90
7%7%7%0% Fejksks iuegkhefj
^ruc`f dc skoekikgfegkf Tulcy fj 3# pfrf ghapfrfr acdkfs dc trftfakceths
skoekikgftkvhs%
7%7%4% Dfths thafdhs y athdhs dc cvfjufgke
7%7%4%6% ^csh
Fj ikefj dc gfdf gkgjh prhdugtkvh sc pcsh cj thtfj dc phjjhs phr trftfakceth y
phr rcpctkgke y sc gfjguj cj pcsh prhacdkh ghe cj ush dc jf skoukcetc iraujf=
-
7/23/2019 EVALUACIN DEL EFECTO DE UN PROBITICO NATIVO ELABORADOEN BASE A Lactobacillus acidophilus y Bacillus su
50/105
79
7%7%4%0% Ghevcrske Fjkacetkgkf
Wc jjcv ue ghetrhj dkfrkh dcj ghesuah dc fjkaceth dc gfdf trftfakceth y fj
ikefj sc gfjguj acdkfetc jf skoukcetc iraujf=
7%7%4%7 Ahrtfjkdfd
Wc ghetf`kjkz jf ahrtfjkdfd dkfrkf y fj ikefj dc gfdf jhtc prhdugtkvh sc gfjguj
ce phrgcetfmc pfrf sus rcspcgtkvfs ghapfrfgkhecs%
7%7%4%4% Fejksks `fgtcrkhjokgh
Wc cevkfrhe aucstrfs f ue jf`hrfthrkh cspcgkfjkzfdh pfrf jf kdcetkikgfgke y
dctcrakefgke dc `fgtcrkfs pftocefs ce jfs fvcs%
7%7%3%ATHDHW CW^CGIKGHW DC AFECMH DCJ CR^CPKACETH
7%7%3%6% Jkapkczf y dcskeicggke dcj ofjpe
Wc prhgcdk f jfvfr cj ofjpe utkjkzfedh dctcrocetc kedustrkfj "tkphj+%
^frf cj ghetrhj dc kescgths y gfrhs prcscetcs ce jf gfaf sc iuako ghe
gkpcractrkef%
Jf dcskeicggke dcj ofjpe y dc cqukphs sc rcfjkz ghe ihrahj y GKD!0>
"ihrafjdcbkdh 0>#+%
-
7/23/2019 EVALUACIN DEL EFECTO DE UN PROBITICO NATIVO ELABORADOEN BASE A Lactobacillus acidophilus y Bacillus su
51/105
7?
7%7%3%0% ^rcpfrfgke dcj ofjpe fetcs dc jf rcgcpgke dc jhs phjjkths
Wc utkjkzfrhe ghrtkefs dc jhef pfrf bcractkzfr ghapjctfacetc cj ofjpe%
Wc ghjhgfrhe tfequcs dc fouf y afeoucrfs pfrf gfdf trftfakceth%
Tfa`ke sc rcfjkzfrhe ghrrfjcs pfrf rcgk`kr f jhs phjjkths ``* utkjkzfedh uef
dceskdfd dc 4> phjjhs(a0%
Ghjhgfgke dc jfs grkfdhrfs uekihracacetc fj gcetrh dcj ghrrfj "grkfdhrf
Ofshjcg 03>> Lgfj ghe uef gfpfgkdfd pfrf 6>>> phjjkths+
Wc dkstrk`uy uekihracacetc thdh cj cqukph pfrf cj cesfyh%
7%7%3%7% Pcgcpgke dc jhs phjjkths
Wc prhgcdk f ghjhgfr jf rfgke fjkacetkgkf pfrf gfdf trftfakceth* dc koufj
afecrf cj fouf dc `c`kdf%
^frf jhorfr afetcecr uef tcapcrfturf kdcfj jfs grkfdhrfs sc prcedkcrhe scks
bhrfs fetcs dc jf jjcofdf dc jhs phjjkths%
Jhs phjjkths sc ghjhgfrhe dc`fmh dc jf grkfdhrf%
7%7%3%4% ^rhorfaf dc Yfguefgke
? DKFW=
64 jktrhs dc fouf phr gfdf 6>>> phjjhs
7 orfahs dc jcgbc ce phjvh phr jktrh dc fouf
6 dhsks dc vfguef phr fvc