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Universitat Autònoma de Barcelona
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i
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ii
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iii
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iv
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________________________________________________________________________Abreviaturas
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________________________________________________________________________Resumen
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SÍNTOMAS TRATAMIENTOS
Síntomas primarios
Síntomas secundarios
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Síntomas terciarios
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CRITERIOS DE CLASIFICACIÓN DE LA EVOLUCIÓN CLÍNICA DE LA EM
Recaídas y remisiones (RR) Brotes bien definidos, a menudo con recuperación completa o casi completa. Sin progresión de la enfermedad entre ataques.
Recaídas y progresión (RP) Avance de la enfermedad con recaídas, sin recuperación entre ellas.
Primariamente progresivo (PP) Empeoramiento continuo de los síntomas neurológicos y deficiencias. Generalmente sin remisión o exacerbaciones agudas.
Secundariamente progresivo (SP) Agravamiento continuo de los síntomas. Aparece después de una etapa de RR.
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Vector Material genético
Capacidad de empa-quetamiento
Tropismo Potencial inflamatorio
Forma del genoma viral en la célula
Principales limitaciones
Principales ventajas
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Subgrupos de HAd Serotipos Tropismo natural predominante Receptores conocidos
A 12, 18, 31 gastrointestinal CAR
B1 3, 7, 16, 21, 50 respiratorio CD46, CD80/86, Receptor X, HSPG
B2 11, 14, 34, 35 renal CD46, CD80/86, Receptor X, HSPG
C 1, 2, 5, 6 respiratorio CAR, HSPG, MHC-I, VCAM-I, Integrinas
D 8, 9, 10, 13, 15, 17, 19, 20, 22-30, 32, 33, 36-39, 42-49, 51
ocular CAR, acido sialico, CD46
E 4 respiratorio, ocular CAR
F 40, 41 gastrointestinal CAR
G 52 gastrointestinal -----
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