CURRICULUM VITAE DATOS PERSONALES NOMBRE: LUIS FRANCISCO HERNANDEZ RODRIGUEZ. FECHA DE NACIMIENTO: 5 DE FEBRERO DE 1942. LUGAR DE NACIMIENTO: CARACAS - VENEZUELA. ESTUDIOS REALIZADOS

Bachiller en Ciencias 1959. Liceo Andrés Bello - Caracas-Venezuela. Primero en la Promoción. Médico Cirujano. 1966. Universidad de los Andes (U.L.A.) - Mérida-Venezuela. Primero en la Promoción. AREAs DE INVESTIGACION DE MAYOR INTERES: NEUROFISIOLOGIA, NEUROQUIMICA Y ELECTROFORESIS CAPILAR. PREMIOS Y DISTINCIONES OBTENIDAS: - PREMIO NACIONAL A LA INNOVACION TECNOLOGICA 1993 OTORGADO POR EL CONICIT. - ORDEN ANDRES BELLO EN 2DA. CLASE, 1993. - PREMIO FRANCISCO DE VENANZI 1994. - MIEMBRO DE NUMERO DE LA ACADEMIA DE MERIDA.

- INVESTIGADOR DEL NIVEL IV SEGUN LA CLASIFICACION DEL PLAN DE PROMOCION DEL INVESTIGADOR (PPI).

- PREMIO “LORENZO MENDOZA FLEURY” OTORGADO POR LA FUNDACION POLAR. Mayo 1995. - ORDEN “DON TULIO FEBRES CORDERO” OTORGADA POR LA ASAMBLEA LEGISLATIVA DEL ESTADO MERIDA. MAYO 1995.

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- ORDEN “DON TULIO FEBRES CORDERO” OTORGADA POR LA ASAMBLEA LEGISLATIVA DE MERIDA AL MEJOR GRUPO DE INVESTIGACION DE LA UNIVERSIDAD DE LOS ANDES. OCTUBRE 1996. - PREMIO NACIONAL DE CIENCIAS MENCION INNOVACION TECNOLOGICA OTORGADO POR EL CONICIT, Diciembre de 1998. - MIEMBRO DE LA ACADEMIA DE CIENCIAS DE AMÉRICA LATINA. - PROFESOR TITULAR DE LA CATEDRA HONORARIA SANTIAGO RAMON Y CAJAL DE LA FACULTAD DE MEDICINA DE LA UNIVERSIDAD NACIONAL AUTONOMA DE MEXICO, 2003 - MEDALLA DE HONOR CONCEDIDA POR EL INSTITUTO VENEZOLANO DE INVESTIGACIONES CIENTIFICAS (IVIC), 2004.

CONTRIBUCIONES A CONGRESOS INTERNACIONALES

Presentación de más de 119 trabajos. Chairman en varios de ellos. REVISTAS Y CONGRESOS: Miembro del Board Internacional de editores de la revista JOURNAL OF CAPILLARY ELECTROPHORESIS. Miembro del Board Internacional de editores de la Conferencia IN VIVO METHODS TO MONITOR MOLECULES. SOCIEDADES A LAS QUE PERTENECE: Sociedad Venezolana de Ciencias Fisiológicas. Venezuela. ASOVAC. Venezuela. Neuroscience Society. Estados Unidos de América. British Brain Research Association. Inglaterra. European Brain and Behavior Society. International Brain Research Organization. World. Federation of Neuroscientists. Estados Unidos de América. New York Academy of Sciences. American Chemical Society. Sigma Xi Society. American Association for the Advancement of Science. CARGOS UNIVERSITARIOS DESEMPEÑADOS: Preparador, Departamento de Anatomía, U.L.A., 1961 a 1963. Preparador, Departamento de Bioquímica, U.L.A., 1964. Instructor en Fisiología, Departamento de Fisiología, U.L.A., 1967.

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Profesor Asistente de Fisiología, Departamento de Fisiología, U.L.A., 1970. Profesor Agregado de Fisiología, Departamento de Fisiología, U.L.A., 1974.

Visiting Fellow, Princeton University, NJ., U.S.A., 1975. Research Associate. Neuroscience Program. Princeton University, NJ. U.S.A., 1976 a 1979. Profesor Asociado de Fisiología, Departamento de Fisiología, U.L.A., 1983. Coordinador General del Consejo de Desarrollo Científico, Humanístico y Tecnológico (C.D.C.H.T.), U.L.A., 1980 a 1984. Visiting Senior Scientist. Neuroscience Program. Princeton University,NJ., U.S.A., 1986 a 1988. Profesor Titular de Fisiología, Departamento de Fisiología, U.L.A., desde el 15 de Noviembre de1988.

ACTIVIDADES SOCIALES: Presidente del Centro de Estudiantes de Medicina: 1964 Presidente de la Federación de Centros Universitarios: 1965 Vicepresidente del Colegio de Médicos: 1969 PATENTES: 1.) SONDA DE MICRODIALISIS:

Inventor: Luis Hernández Nº en Francia: FR/89 08 013 Fecha: 16 06 89 Publicación Nº:2 648 353 Nº en Europa: 90 401 680.5 Fecha: 15 06 90 Publicación Nº 0 403 394 Nº en US: 5 106 365 Fecha: 15 06 90. 2.) CAPILAR CON DISPOSITIVO OPTICO INCORPORADO PARA ELECTROFORESIS CAPILAR: Inventor: Luis Hernández

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Nº en Francia: FR/89 08 257 Fecha: 29 09 91 Publicación Nº:2 649 487 Nº en Europa: 90 401 6 79.7 Publicación Nº:0 404 646 Fecha: 15 06 90 Nº en US: 5228 969 Fecha: 20 07 93.

3.) PROCEDIMIENTO ANALITICO PARA ELECTROFORESIS CAPILAR CON DETECCION MEDIANTE FLUORESCENCIA INDUCIDA POR LASER:

Inventor: Luis Hernández Nº en Francia: 91 00 144 Fecha de aceptación: 08 01 91. ARTICULOS PUBLICADOS: 1. BRIESE, E. and HERNANDEZ. L. Self-stimulation Enhancement in

Diabetic Rats. Acta Physiologica Latinoamericana, XX: 24-29, 1970. 2. BRIESE, E. and HERNANDEZ, L. Hypothalamic Mechanism of Diabetic

Hyperphagia.Acta Physiologica Latinoamericana, XXI (Suppl. 1): 31, 1970. 3. BRIESE, E., RONDON MORALES, R. and HERNANDEZ, L. Glucostatic

Modulation of the Hypothalamus by Phenformin. Physiology and Behavior , 7 (6): 807-810, 1971.

4. HERNANDEZ, L. and BRIESE, E. Insulin Inhibition of Hypothalamic Self-stimulation. Acta Physiologica Latinoamericana, XXI: 57-63, 1971.

5. HERNANDEZ, L. and BRIESE, E. Analysis of Diabetic Hyperphagia and Polydipsia. Physiology and Behavior, 9 (5): 741-746, 1972.

6. HOEBEL, BG., HERNANDEZ, L. and THOMPSON, RD. Phenylpropanolamine Inhibits Feeding, but not Drinking, Induced by Hypothalamic Stimulation. J. Comp. Physiol. Psychol. 89 (9): 1046-1052, 1975.

7. RESNICK, SI., HERNANDEZ, L., CHEN, J. and HOEBEL, B.G. Effect of the Anorectic Drug, Phenylpropanolamine, on Blood Glucose in Rats. Pharmacology, 17: 157-162, 1978.

8. HERNANDEZ, LUIS. Optic discriminator for Single Cell Activity. Physiology and Behavior, 25(4): 607-610, 1980.

9. HERNANDEZ, L. and GOTTBERG, E. Systemic Insulin decreases Lateral Hypothalamic Unit Activity. Physiology and Behavior, 25(6): 981-984, 1980.

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10. HOEBEL, BG., HERNANDEZ, L., MONACO, A.P. and MILLER, W.C. Amphetamine-induced Overeating and Overweight in Rats.Life Sciences, 28(1): 77-82, 1981.

11. HERNANDEZ, L. and HOEBEL, B.G. Overeating after Midbrain 6-Hydroxydopamine: Prevention by Central Injection of Selective Catecholamine Reuptake Blockers. Brain Research, 245: 333-343, 1982.

12. HERNANDEZ, L., PAEZ, X. and HAMLIN, C. Neurotransmitters Extraction by Local Intracerebral Dialysis in Anesthetized Rats. Pharmacology Biochemistry and Behavior, 8(2): 159-162, 1983.

13. HERNANDEZ, L., PARADA, M. and HOEBEL, B.G. Amphetamine-Induced Hyperphagia and Obesity caused by Intraventricular or Lateral Hypothalamic Injections in Rats. J. Pharmacol. & Exper. Ther. 227: 524-530, 1983.

14. HOEBEL, BG., MONACO, A.P., HERNANDEZ, L., AULISI, E.F., STANLEY, B.G. and LENARD, L. Self-injection of Amphetamine directly into the Brain. Psychopharmacology, 81: 158-163, 1983.

15. AHLSKOG, JE., RANDALL, P.K., HERNANDEZ, L. and HOEBEL, B.G. Diminished Amphetamine Anorexia and Enhanced Fenfluramine Anorexia after Midbrain 6-Hydroxydopamine. Psychopharmacology, 82: 118-121, 1984.

16. HERNANDEZ, L., VALDERRAMA, A. and LISCANO, E. Efectos de la dieta sobre la reproducción de dos especies de triatominos: Rhodnius Prolixus y Triatoma Maculata. Revista Brasileira do Biologia. 1985.

17. BAPTISTA, T., PARADA, M. and HERNANDEZ, L. Pharmacological evidence that dopaminergic satiety systems function with D2 type receptors. Appetite, 7: 240, 1986.

18. HERNANDEZ, L., STANLEY, B.G. and HOEBEL, B.G. A small, removable microdialysis probe.

Life Sciences, 39: 2629-2637, 1986. 19. MURZI, E., HERNANDEZ, L. and BAPTISTA, T. Lateral hypothalamic

sites eliciting eating affect medullary taste neurons in rats. Physiology and Behavior, 36 (5): 829-834, 1986.

20. BAPTISTA, T., PARADA, M. and HERNANDEZ, L. Long term administration of some antipsychotic drugs increases body weight and feeding in rats: Are D2 Dopamine receptors involved? Pharmacology Biochemistry and Behavior, 27(3): 399-405, 1987.

21. HERNANDEZ, L., LEE, F. and HOEBEL, B.G. Simultaneous microdialysis and amphetamine infusion in the Nucleus Accumbens and Striatum of freely moving rats: Increase in extracellular dopamine and serotonin. Brain Res. Bull. 19(6): 623-628, 1987.

22. HERNANDEZ, L., AUERBACH, S. and HOEBEL, B.G. Phencyclidine (PCP) injected in the Nucleus Accumbens increases extracellular dopamine and serotonin as measured by microdialysis. Life Sciences , 42(18): 1713-1723, 1988.

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23. HERNANDEZ, L. and HOEBEL, B.G. Food reward and cocaine increase extracellular dopamine in the Nucleus Accumbens as measured by microdialysis. Life Sciences, 42 (18): 1705-1712, 1988.

24. HERNANDEZ, L. and HOEBEL, B.G. Feeding and hypothalamic stimulation increase dopamine turnover in the Accumbens. Physiol. & Behav. 44 (4/5): 599-606, 1988.

25. HERNANDEZ, L. and HOEBEL, B.G. Monoamine increase by cocaine and procaine in the nucleus accumbens: A microdialysis study. Soc. Neurosci. Abstr. 14: 658, 1988.

26. HOEBEL, B.G., HERNANDEZ, L., MC CLELLAND, R.C. and SCHWARTZ, D. Dexfenfluramine and Feeding reward. Clinical Neuropharmacology, 11 (Suppl. I): S72-S83, 1988.

27. PARADA, M.A., HERNANDEZ, L. and HOEBEL, B.G. Sulpiride injections in the lateral hypothalamus induce feeding and drinking in rats. Pharmacology Biochemistry and Behavior, 30(4): 917-923, 1988.

28. PARADA, M.A., HERNANDEZ, L. and SANTIAGO, C. An improved circular tilt-cage shows that intrahypothalamic injections of sulpiride increase locomotion. Brain Research Bulletin, 21(6): 873-880, 1988.

29. PARADA, M.A., HERNANDEZ, L., SCHWARTZ, D. and HOEBEL, B.G. Hypothalamic infusion of amphetamine increases serotonin, dopamine, and norepinephrine. Physiology and Behavior, 44(4/5): 607-610, 1988.

30. ADVIS, J.P., HERNANDEZ, L. and GUZMAN, N.A. Analysis of brain neuropeptides by capillary electrophoresis: determination of luteinizing hormone-releasing hormone from ovine hypothalamus. Peptide Research, 2(6): 389-394, 1989.

31. GUZMAN, NA., HERNANDEZ, L. and ADVIS, J.P. Effect of low temperature storage (on collected urine specimens) in the identification and quantitation of urinary metabolites by capillary electrophoresis. Journal of Liquid Chromatography, 12(13): 2563-2574, 1989.

32. GUZMAN, N.A., HERNANDEZ, L. and HOEBEL, B.G. Capillary electrophoresis: A new era in microseparations. Biopharm. 2: 22-37, 1989.

33. HERNANDEZ, L. and HOEBEL, B.G.Haloperidol given chronically decreases basal dopamine in the prefrontal cortex more than the striatum or nucleus accumbens as simultaneously measured by microdialysis. Brain Research Bulletin, 22 (4): 763-769, 1989.

34. HERNANDEZ, L. and HOEBEL, B.G. Food intake and lateral hypothalamic self- stimulation covary after medial hypothalamic lesions or ventral midbrain 6-hydroxydopamine injections that cause obesity. Behavioral Neurosciences, 103(2): 412-422, 1989.

35. HOEBEL, B.G. and HERNANDEZ, L. Microdialysis studies of Psicostimulants.

NIDA Monographs. 1989. 36. MC CLELLAND, R.C., SARFATY, T., HERNANDEZ, L. and HOEBEL,

B.G. The appetite suppressant, d-fenfluramine, decreases self-stimulation at a

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feeding site in the lateral hypothalamus. Pharmacology, Biochemistry and Behavior, 32(2): 411-414, 1989.

37. MIFSUD, J.C., HERNANDEZ, L. and HOEBEL, B.G. Nicotine infused into the nucleus accumbens increases synaptic dopamine as measured by in vivo microdialysis. Brain Research, 478: 365-367, 1989.

38. PARADA, MA., HERNANDEZ, L. and HOEBEL, B.G. Is dopamine in the lateral hypothalamus involved in the inhibitory regulation of exploratory behavior related to food and water seeking? Appetite, 12: 229-230, 1989.

39. PARADA, M. A., HERNANDEZ, L., PAEZ, X., BAPTISTA, T., PUIG DE PARADA, M. and QUIJADA, M.G.Mechanism of the body weight increase induced by systemic sulpiride. Pharmacology, Biochemistry and Behavior, 33(1): 45-50, 1989.

40. SCHWARTZ, D., HERNANDEZ, L. and HOEBEL, B.G. Fenfluramine administered systemically or locally increases extracellular serotonin in the lateral hypothalamus as measured by microdialysis. Brain Research, 482: 261-270, 1989.

41. SCHWARTZ, D., MCCLANE, S., HERNANDEZ, L. and HOEBEL, B.G. Feeding increases extracellular serotonin in the lateral hypothalamus of the rat as measured by microdialysis. Brain Research, 479: 349-354, 1989.

42. SILVA, E. and HERNANDEZ, L. Goldthioglucose causes brain norepinephrine and serotonin depletion correlated with increased body weight. Brain Research, 490: 192-195, 1989.

43. STANLEY, BG., SCHWARTZ, D.H., HERNANDEZ, L., HOEBEL, B.G. and LEIBOWITZ, S.F. Patterns of extracellular norepinephrine in the paraventricular hypothalamus: Relationship to circadian rhythm and deprivation-induced eating behavior. Life Sci. 45: 275-282, 1989.

44. STANLEY, BG., SCHWARTZ, D.H., HERNANDEZ, L., LEIBOWITZ S.F. and HOEBEL, B.G. Patterns of extracellular 5-hydroxyindoleacetic acid (5-HIAA) in the paraventricular hypothalamus (PVN): Relationship to circadian rhythm and deprivation-induced eating behavior. Pharmacology, Biochemistry and Behavior, 33(1): 257-260, 1989.

45. BAPTISTA, T., HERNANDEZ, L., BURGUERA, J.L., BURGUERA, M. and HOEBEL, B.G. Chronic lithium administration enhances serotonin release in the lateral hypothalamus but not in the hippocampus in rats. A microdialysis study. Journal of Neural Transmission, 82(1): 31-41, 1990.

46. BAPTISTA, T., HERNANDEZ, L. and HOEBEL, B.G. Systemic sulpiride increases dopamine metabolites in the lateral hypothalamus. Pharmacol. Biochem. & Behav. 37(2): 227-229, 1990.

47. BRIESE, E., RADA, P. and HERNANDEZ, L. Electrical hypothalamic stimulation in rats induces hyperthermia if and only if they learn to self-stimulate. Physiology & Behavior, 47(4): 635-639, 1990.

48. GUZMAN, NA., BERCK, C.M., HERNANDEZ, L. and ADVIS, J.P. Capillary Electrophoresis as a Diagnostic Tool-Determination of Biological

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Constituents Present in Urine of Normal and Pathological Individuals. Journal of Liquid Chromatography, 13(19): 3833-3848, 1990.

49. HERNANDEZ, L., BAPTISTA, T. and HOEBEL, B.G. Neurochemical effects of chronic haloperidol and lithium assessed by brain microdialysis in rats. Prog. Neuro-Psychopharmacol. & Biol. Psychiat. 14(Suppl): S17-S35, 1990.

50. HERNANDEZ, L. and HOEBEL, B.G. Feeding enhances dopamine turnover in the prefrontal cortex. Brain Res. Bull. 25(6): 975-979, 1990.

51. HERNANDEZ, L. et JOSHI, N. L'electrophorese capillaire et la détection en fluorescence induite par laser. Spectra 2000 No. 153, pp. 40-43, 1990.

52. HERNANDEZ, L., MARQUINA, R., ESCALONA, J. and GUZMAN, N. Detection and quantification of capillary electrophoresis zones by fluorescence microscopy. J. Chromatogr. 502: 247-255, 1990.

53. PARADA, M. A., HERNANDEZ, L., PUIG DE PARADA, M., PAEZ, X. and HOEBEL, B.G. Dopamine in the lateral hypothalamus may be involved in the inhibition of locomotion related to food and water seeking. Brain Research Bulletin, 25 (6): 961-968, 1990.

54. RADA, P. and HERNANDEZ, L. Opposite changes of dopamine turnover in prefrontal cortex and nucleus accumbens after amygdaloid kindling. Neurosci. Letters, 117: 144-148, 1990.

55. SCHWARTZ, D.H., HERNANDEZ, L. and HOEBEL, B.G. Serotonin release in lateral and medial hypothalamus during feeding and its anticipation. Brain Res. Bull. 25(6): 797-802, 1990.

56. SCHWARTZ, David H., HERNANDEZ, L. and HOEBEL, B.G. Tryptophan increases extracellular serotonin in the lateral hypothalamus of food-deprived rats. Brain Research Bulletin, 25 (6): 803-807, 1990.

57. BAPTISTA, T., MURZI, E., HERNANDEZ, L., BURGUERA, J.L. and BURGUERA, M. Mechanism of the sex-dependent effect of lithium on body weight in rats. Pharmacology Biochemistry and Behav. 38 (3): 533-537, 1991.

58. HERNANDEZ, L., ESCALONA, J., JOSHI, N. and GUZMAN, N. Laser- induced fluorescence and fluorescence microscopy for capillary electrophoresis zone detection. J. Chromatogr. 559: 183-196, 1991.

59. HERNANDEZ, L., GUZMAN, N.A. and HOEBEL, B.G. Bidirectional microdialysis in vivo shows differential dopaminergic potency of cocaine, procaine and lidocaine in the nucleus accumbens using capillary electrophoresis for calibration of drug outward diffusion. Psychopharmacology, 105: 264-268, 1991.

60. HERNANDEZ, L., PARADA, M., BAPTISTA, T., SCHWARTZ, D., WEST, H.L, MARK, G.P., and HOEBEL, B.G. Hypothalamic serotonin in treatments for feeding disorders and depression as studied by brain microdialysis. J. Clin. Psychiatry, 53: 1 (Suppl. 12), 32-40, 1991.

61. MURZI, E., BAPTISTA, T. and HERNANDEZ, L.Hypothalamic sites affecting masticatory neurons in rats. Brain Research Bulletin, 26 (3): 321-325, 1991.

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62. PARADA, M.A., PUIG DE PARADA, M., HERNANDEZ, L. and MURZI, E. Ventromedial hypothalamus vs. lateral hypothalamic D2 satiety receptors in the body weight increase induced by systemic sulpiride. Physiology and Behavior, 50 (6): 1161-1165, 1991.

63. BURGUERA, J.L., BURGUERA, M., HERNANDEZ, L., DE LA GUARDIA, M. and SALVADOR, A. Flow injection analysis with front-surface illumination laser induced fluorescence spectrometry for analytical applications. J. Flow Injection Anal., 9 (1): 39-46, 1992.

64. GONZALEZ, L., PARADA, M. and HERNANDEZ, L. Pyridoxine acts in the brain to reduce ethanol toxicity in rats. Alcohol, 9 (6): 519-522, 1992.

65. PARADA, M.A., HERNANDEZ, L., and DEGOMA, E. Serotonin may play a role in the anorexia induced by amphetamine injections into the lateral hypothalamus.Brain Research, 577: 218-225, 1992.

66. TELLEZ, S., FORGES, N., ROUSSIN, A. and HERNANDEZ, L. Coupling of microdialysis with capillary electrophoresis: a new approach to the study of drug transfer between two compartments of the body in freely moving rats. Journal of Chromatography, 581: 257-266, 1992.

67. TOULAS, C. and HERNANDEZ, L. Applications of a New Laser-induced fluorescence detector for Capillary Electrophoresis to measure Attomolar and Zeptomolar amounts of compounds. Liquid Chromatography and Gas Chromatography International, 5(3): 27-30, 1992.

68. TOULAS, C. and HERNANDEZ, L. A highly sensitive capillary electrophoresis laser induced fluorescence detection method to measure zeptomole amount of bradikinine. Analusis, 20: 49-51, 1992.

69. BAPTISTA, T., TENEUD, L. and HERNANDEZ, L. Enhancement of amphetamine anorexia after chronic administration of sulpiride in rats. Pharmacology, Biochemistry & Behavior, 45 (1): 45-49, 1993.

70. BAPTISTA, T., A. MATA, L. TENEUD, M. DE QUIJADA, HUI-WAN HAN, and L. HERNANDEZ. Effects of long-term administration of clozapine on body weight and food intake in rats. Pharmacology, Biochemistry & Behavior, 45 (1): 51-54, 1993.

J. Neural Transm., 94 (2): 75-89, 1993. 72. HERNANDEZ, L., ESCALONA, J., VERDEGUER, P. and GUZMAN,

N.A. In vivo monitoring of brain glutamate by microdialysis coupled to capillary electrophoresis and laser induced fluorescence detection. Journal of Liquid Chromatography, 16 (9 & 10): 2149-2160, 1993.

71. BAPTISTA, T., TENEUD, L., CONTRERAS, Q., BURGUERA, J.L., BURGUERA, M. and HERNANDEZ, L. Effects of acute and chronic lithium treatment on amphetamine-induced dopamine increase in the nucleus accumbens and prefrontal cortex in rats as studied by microdialysis.

73. HERNANDEZ, L., JOSHI, N., MURZI, E., VERDEGUER, P., MIFSUD, J.C. and GUZMAN, N. Collinear laser-induced fluorescence detector for capillary electrophoresis. Analysis of Glutamic acid in brain dialysates. Journal of Chromatography A, 652: 399-405, 1993.

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74. HERNANDEZ, L., TUCCI, S., GUZMAN, N. and PAEZ, X. In vivo monitoring of glutamate in the brain by microdialysis and capillary electrophoresis with laser-induced fluorescence detection. Journal of Chromatography A, 652: 393-398, 1993.

75. RADA, P., PARADA, M., and HERNANDEZ, L. Flexible intravenous microdialysis probe for blood sampling in freely moving rats. Journal of Applied Physiology, 74 (1): 466-469, 1993.

76. ROUSSIN, A., VERDEGUER, PH. et HERNANDEZ, L. Le couplage de la microdialyse et de l'électrophorèse capillaire pour l'analyse in vivo. Analusis Magazine, 21 (3): 42-45, 1993.

77. HERNANDEZ, L., L. GONZALEZ, E. MURZI, X. PAEZ, E. GOTTBERG, and T. BAPTISTA.Testosterone modulates mesolimbic dopaminergic activity in male rats. Neuroscience Letters, 171: 172-174, 1994.

78. SILVA, E., CATALAN, M., HERNANDEZ, L., TENEUD, L., AND BAPTISTA, T. Hyponatremia and neuroleptic-induced obesity in rats. Research Communications in Molecular Pathology and Pharmacology, 85 (2): 237-240, 1994.

79. TUCCI, S., FERNANDEZ, R., BAPTISTA, T., MURZI, E. and HERNANDEZ, L. Dopamine increase in the prefrontal cortex correlates with reversal of haloperidol-induced catalepsy in rats. Brain Research Bulletin, 35 (2): 125-133, 1994.

82. DALHOEVEN, G.A.M., N.V. JOSHI, N. RODRIGUEZ AND L. HERNANDEZ. Simultaneous measurements of capillary electrophoresis fluorescence peaks and their corrersponding spectra. Journal of Chromatography, 18 (18 & 19): 3729-3749, 1995.

83. DAVILA, D.F., G. BELLABARBA, L. HERNANDEZ, G. CALMON, A. TORRES, J.H. DONIS, J. S. BARBOZA, C. LEMORVAN, J.G. GONZALEZ. Plasma norepinephrine, myocardial damage and left ventricular systolic function in Chagas’ heart disease. International Journal of Cardiology, 52: 145-151, 1995.

84. HERNANDEZ, L. AND B.G. HOEBEL. Chronic clozapine selectively decreases prefrontal cortex dopamine as shown by simultaneous cortical, accumbens and striatal microdialysis in freely moving rats. Pharmacol. Biochem. Behav., 52(3): 581-589, 1995.

80. BAPTISTA, T., TENEUD, L., CONTRERAS, Q., ALASTRE, T., BURGUERA, J.L., BURGUERA, M. and HERNANDEZ, L. Chronic lithium administration enhances amphetamine-induced norepinephrine increase in the paraventricular nucleus of the hypothalamus in rats: an in vivo microdialysis study. Prog. Neuro-Psychopharmacol. & Biol. Psychiat., 19: 273-279, 1995.

81. BAPTISTA, T., L. TENEUD, Q. CONTRERAS, T. ALASTRE, J.L.BURGUERA, M. DE BURGUERA, E. DE BAPTISTA, S. WEISS, L.HERNANDEZ. Lithium and body weight gain. Pharmacopsychiat. 28: 35-44, 1995.

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85. JOSHI, N.V., V.O.DE JOSHI, N. RODRIGUEZ, AND L. HERNANDEZ. Fluorescence Microscopic Spectral Study of Fluorescein and some Amino Acids. SPIE, 2386: 303-309, 1995.

86. NOUADJE, G., F. COUDERC, P. PUIG, AND L. HERNANDEZ. Combination of micellar electrokinetic chromatography and laser-induced fluorescence detection for the determination of pressor amines and some principal amino acids in wine. J. Capillary electrophoresis, 002(3): 117-124, 1995.

87. PARADA, M.A., PUIG DE PARADA, M., HERNANDEZ, L. AND HOEBEL, B.G. Triple electrical channels on a triple fluid swivel and its use to monitor intracraneal temperature with a thermocouple. J. Neurosci. Meth. 60: 133-139, 1995.

88. PARADA, M.A., PUIG DE PARADA, M., RADA, P. AND HERNANDEZ, L. Sulpiride increases and dopamine decreases intracranial temperature in rats when injected in the lateral hypothalamus: an animal model for the neuroleptic malignant syndrome?. Brain Res. 674: 117-121 (1995).

89. PUIG DE PARADA, M., PARADA, M., AND HERNANDEZ, L. Dispogenic effect of Pituitary Adenylciclase Activating Polipeptide (PACAP 38) injected into the lateral hypothalamus. Brain Research, 696: 254-257, 1995.

90. BRIESE, E. AND L. HERNANDEZ. Ethanol anapyrexia in rats. Pharmacol. Biochem. Behav., 54(2) 399-402, 1996.

91. KHOURY, A.M., D.F. DAVILA, G. BELLABARBA, J.H. DONIS, A.TORRES, C. LEMORVAN, L. HERNANDEZ, W. BISHOP. Acute effects of digitalis and enalapril on the neurohormonal profile of chagasic patients with severe congestive heart failure. Int. J. Cardiology, 57: 21-29, 1996.

92. MAS, M., GONZALEZ-MORA, J.L., AND L. HERNANDEZ. In Vivo Monitoring of Brain Neurotransmitter Release for the Assessment of Neuroendocrine Interactions. Molecular and Cellular Biology, 16(3): 383-396, 1996.

93. MURZI, E., Q. CONTRERAS, L. TENEUD, B. VALECILLOS, M. A. PARADA, M. PUIG DE PARADA and L. HERNANDEZ. Diabetes decreases limbic extracellular dopamine in rats. Neuroscience Letters: 202: 141-144, 1996.

94. OTERO DE JOSHI, V., H. GIL, S. CONTRERAS, N.V. JOSHI, AND L. HERNANDEZ. Spectral Investigation of Somatotropin for different pH. SPIE, 2676: 284-289, 1996.

95. PAEZ, X., RADA, P., TUCCI, S., RODRÍGUEZ, N. and HERNANDEZ, L. Capillary electrophoresis and laser induced fluorescence to detect amphetamine

in the brain. JOURNAL OF CHROMATOGRAPHY A. 735 (1-2): 263-269, 1996.

96. X. PAEZ, L. HERNANDEZ. Serotonin and 5-hydroxyindoleacetic acid differential changes after d-norfenfluramine or fluoxetine assessed by simultaneous brain and blood microdialysis. LIFE SCIENCES, 58: 1209-1221, 1996.

97. TENEUD, L.M., BAPTISTA, T., MURZI, E., HOEBEL B.G. and HERNANDEZ, L.

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Systemic and local cocaine increase extracellular serotonin overflow in the nucleus accumbens in rats.

Pharmacol. Biochem. Behav. 53(3): 747-752, 1996. 98. BAPTISTA, T., ALASTRE, T., CONTRERAS, Q., TENEUD, L.,

MARTINEZ, J.L., DE BAPTISTA, E., BURGUERA, J.L., BURGUERA, M., & HERNANDEZ, L. Effects of lithium carbonate on reproductive hormones in healthy men: relationship with body weight regulation. A pilot study. Prog. Neuropsychopharmacol. Biol. Psychiat., 21: 937-950, 1997.

99. BAPTISTA, T., ARAUJO DE BAPTISTA, E., HERNÁNDEZ, L., ALTEMUS, A. & WEISS, S.R.B. Tamoxifen prevents sulpiride-induced weight gain in female rats. Pharmacology Biochemistry and Behavior., 57 (1-2): 215-222, 1997.

100. BAPTISTA, T., M.E. LOPEZ, L. TENEUD, Q. CONTRERAS, T. ALASTRE, M. de QUIJADA, E. ARAUJO DE BAPTISTA, M. ALTERNUS, S.R.B. WEISS, E. MUSSEO, X. PAEZ, and L HERNANDEZ. Amantadine in the treatment of neuroleptic-induced obesity in rats: behavioral, endocrine and neurochemical correlates. Pharmacopsychiat., 30: 43-54, 1997.

101. BAPTISTA, T., ALASTRE, T., CONTRERAS, Q., MARTINEZ, J.L., DE BAPTISTA, E. & HERNANDEZ, L. Effects of antipsychotic drug sulpiride on reproductive hormones in healthy men: relationship with body weight regulation. Prog. Neuropsychopharmacol. Biol. Psychiat., 30: 250-255, 1997.

102. BAPTISTA, T., CALANCHE, L., DE QUIJADA, M., MARTINEZ, J.L., DE BAPTISTA, E. & HERNANDEZ, L. Effects of antipsychotic drug sulpiride on reproductive hormones in healthy premenopausal women: relationship with body weight regulation. Prog. Neuropsychopharmacol. Biol. Psychiat., 30: 256-262, 1997.

103. BAPTISTA, T., MOLINA, M.G., MARTINEZ, J.L., DE QUIJADA, M., CALANCHE DE CUESTA, I., ACOSTA, A., PAEZ, X., MARTINEZ, J.M., & HERNANDEZ, L. Effects of the antipsychotic drug sulpiride on reproduction hormones in healthy premenopausal women: relationship with body weight regulation. Pharmacopsychiatry, 30: 1-7, 1997.

104. GUZMAN, N.A., S.S. PARK, D. SCHAUFELBERGER, L. HERNANDEZ, X. PAEZ, P. RADA, A.J. TOMLINSON, S. NAYLOR. New approaches in clinical chemistry: on-line analyte concentration and microreaction capillary electrophoresis for the determination of drugs, metabolic intermediates, and biopolymers in biological fluids. J. Chromatograpg. B: 697: 7-66, 1997.

105. MURZI, E., RADA, P., PUIG DE PARADA, M., PARADA, M., VALECILLOS, B., TILAC, C.A., and HERNANDEZ, L. Atropine decreases drinking but not feeding and induces less hypothalamic acetylcholine-release in diabetic rats. Brain Res., 752: 184-188, 1997.

106. PAEZ, X. and L. HERNANDEZ. Blood microdialysis in humans: a new method for monitoring plasma compounds. Life Sci., 61: 847-856, 1997.

107. PARADA, M.A., HERNANDEZ, L., PUIG DE PARADA, M., RADA, P. and E. MURZI. Selective action of acute systemic clozapine on acetylcholine release in the rat prefrontal cortex by reference to the nucleus accumbens and striatum.

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J. PHARMACOL. EXP. THER. 281: 582-588, 1997. 108. PUIG DE PARADA, M., X. PAEZ, M. A. PARADA, L. HERNANDEZ, G.

MOLINA, E. MURZI, Q. CONTRERAS. Changes in dopamine and acetylcholine release in the rat lateral hypothalamus during deprivation-induced drinking. Neurosci. Lett., 227: 153-156, 1997.

109. RADA, P., S. TUCCI, E. MURZI and L. HERNANDEZ. Extracellular glutamate increase in the lateral hypothalamus and decreases in the nucleus accumbens during feeding. Brain Res., 768: 338-340, 1997.

110. TUCCI, S., RADA, P., SEPULVEDA, M.J., and HERNANDEZ, L. Glutamate measured by six seconds resolution brain microdialysis: capillary electrophoresis and laser-induced fluorescence detection application. Journal Of Chromatography B, 694 (2): 343-349, 1997.

111. BAPTISTA, T., ARAUJO, H., RADA, P., & HERNANDEZ, L. Congenital neuroblastoma in a boy born to a woman with bipolar disorder treated with carbamazepine during pregnancy. Prog. Neuropsychopharmac., 22: 445-454, 1998.

112. BAPTISTA, T., CONTRERAS, Q., L. TENEUD, M.A. ALBORNOZ, ACOSTA, A., PAEZ, X., QUIJADA, M., LACRUZ, A., & L. HERNANDEZ. Mechanism of the neuroleptic-induced obesity in female rats. Prog. Neuropsychopharmacol. Biol. Psychiat., 22: 187-198, 1998.

113. BAPTISTA, T., LACRUZ, A. and HERNANDEZ, L. Glucose tolerance and serum insulin levels in an animal model of obesity induced by the antipsychotic drug, sulpiride. Pharmacol. Toxicol. 83: 57-61, 1998.

114. PARADA, M.A., M.P. DE PARADA, L. HERNANDEZ, E. MURZI, and B.G. HOEBEL. A multipurpose four-channel fluid swivel. Brain Res. Bull., 45: 117-123, 1998.

115. PARADA, M.A., M.P. DE PARADA, L. HERNANDEZ, E. MURZI, F. GARCIA. A practical method for simultaneous multiple intracerebral implantations for microdialysis in rats. Brain Research Protocols, 2: 141-148, 1998.

116. SEPULVEDA, M.J., L. HERNANDEZ, P. RADA, S. TUCCI and E. CONTRERAS. Effect of precipitated withdrawal on extracellular glutamate and aspartate in the nucleus accumbens and chronically morphine-treated rats. An in vivo microdialysis study. Pharmacol. Biochem. Behav., 60(3): 225-262, 1998.

117. PARADA, M., PUIG DE PARADA, M., HERNANDEZ, L. GARCIA, F., MURZI, E., CONTRERAS, Q. Effects of the chronic treatment with clozapine on the clozapine-induced acetylcholine release in the rat prefrontal cortex, nucleus accumbens and striatum. Prog. Neuropsychopharmac. & Biol. Psychiat., 22: 1379-1397, 1998.

118. TUCCI, S., PINTO, C., GOYO, J., RADA, P. and HERNANDEZ, L. Measurement of glutamine and glutamate by capillary electrophoresis and laser induced fluorescence detection in cerebrospinal fluid of meningitis sick children. Clin. Biochem., 31:143-150, 1998.

119. PÁEZ, X. AND HERNANDEZ, L. Plasma serotonin monitoring by blood microdialysis coupled to high-performance liquid chromatography with

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electrochemical detection in humans. Journal Of Chromatography B, 720: 33-38, 1998

120. TUCCI, S., RADA, P. and HERNANDEZ, L. Role of glutamate in the amygdala and Lateral Hypothalamus in conditioned taste aversion. Brain Res., 813: 44-49, 1998.

121. RADA P, TUCCI S, PEREZ J, TENEUD L, CHUECOS S, HERNANDEZ L. In vivo monitoring of gabapentin in rats: a microdialysis study coupled to capillary electrophoresis and laser-induced fluorescence detection. Electrophoresis. 19:2976-2980, 1998

122. BAPTISTA, T., REYES, D., and HERNANDEZ, L. Antipsychotic drugs and reproductive hormones: relationship to body weight regulation. Pharmacol. Biochem. Behav. 62: 409-417, 1999.

123. RADA, P. TUCCI, S., TENEUD, L., PAEZ, X., PEREZ, J., ALBA, G., GARCIA, Y., SACCHETTONI, S., DEL CORRAL, J. AND HERNANDEZ, L. Monitoring G amino butiric acid in human brain and plasma microdialysates using micellar electrokinetic chromatography and laser induced fluorescence detection. Journal Of Chromatography B, 735: 1-10, 1999.

124. PAREDES, D., RADA, P., BONILLA, E., GONZALEZ, L. E., PARADA, M. AND HERNANDEZ, L. Melatonin acts in the nucleus accumbens to increase acetylcholine release and modify the motor activity pattern of rats. Brain Res., 850: 14-20, 1999.

125. CASTEJON, A. M., PAEZ, X., HERNANDEZ, L. AND CUBEDDU, L. X. Use of intravenous microdialysis to monitor changes in serotonin release and metabolism induced by cisplatin in cancer patients. J. Pharmacol. & Exper. Ther. 291: 960-966, 1999.

126. BAPTISTA, T., ALVAREZ, L., LACRUZ, A., DE MENDOZA, S. AND HERNANDEZ. L. Glucose tolerance and serum insulin levels in an animal model of obesity induced by subacute or chronic administration of anti-psychotic drugs. Prog. Neuropsychopharmac. & Biol. Psychiat., 23: 277-287, 1999.

127. PAEZ, X., RADA, P. AND HERNANDEZ, L. Neutral amino acids monitoring in phenylketonuric plasma microdialysates using micellar electrokinetic chromatography and laser induced fluorescence detection. Journal Of Chromatography B, 739: 247-254, 2000.

128. SILVA, E. HERNANDEZ, L. CONTRERAS, Q., GUERRERO, F. AND ALBA, G. Noxious stimulation increases glutamate and arginine in the periaqueductal gray matter in rats: a microdialysis study. Pain, 87: 131-135, 2000.

129. LACRUZ, A., BAPTISTA, T., DE MENDOZA, S., MENDOZA, J. M. AND HERNANDEZ, L. Antipsychotic drug inducer obesity in rats: correlation between leptin, insulin and body weight during sulpiride treatment. Molecular Psychiat. 5: 70-76, 2000.

130. BAPTISTA, T., LACRUZ, A., DE MENDOZA, S., MENDOZA, J. M. BURGUERA, J. L., BURGUERA, M. AND HERNANDEZ, L. Endocrine effects of lithium carbonate in healthy premenopausal women: relationship with

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body weight regulation. Prog. Neuropsychopharmac. & Biol. Psychiat., 24: 1-16, 2000.

131. BAPTISTA, T., LACRUZ, A., ACOSTA, A., COLASANTE, C., DE QUIJADA, M., DE MENDOZA, S., MENDOZA, J. M. AND HERNANDEZ, L. Naltrexone does not prevent the weight gain and hyperphagia induced by the antipsychotic drug sulpiride in rats. Appetite, 34: 77-86, 2000

132. BAPTISTA, T., LACRUZ, A., DE MENDOZA, S., MENDOZA, J. M. SILVERA, R., ANGELES, F., MENDOZA, M. T. AND HERNANDEZ, L. Body weight gain after administration of antipsychotic drugs: correlation with leptin, insulin and reproductor hormones. Pharmacopsychiatry, 33: 81-88, 2000

133. PUIG DE PARADA, M., PARADA, M. A., RADA, P., HERNANDEZ, L. AND HOEBEL, B. G. Dopamine-Acetylcholine interaction in the rat lateral hypothalamus in the control of locomotion. Pharmacol. Biochem. Behav. 66: 227-234, 2000

134. TUCCI S, CONTRERAS Q, PAEZ X, GONZALEZ, L, RADA P, HERNANDEZ L. Medial prefrontal transection enhance social interaction. II: Neurochemical studies. Brain Res. 887:259-265, 2000

135. GONZALEZ, L. E., RUJANO, M, TUCCI, S, PAREDES, D, SILVA, E, ALBA, G, HERNANDEZ L. Medial prefrontal transection enhances social interaction. I: Behavioral studies. Brain Res. 887:7-15, 2000

136. PEREZ, J., COLASANTE, C., TUCCI, S., HERNANDEZ, L, RADA, P. Effects of feeding on extracellular levels of glutamate in the medial and lateral portion of the globus pallidus of freely moving rats. Brain Res. 877(1):91-4, 2000

137. BAPTISTA T, HERNANDEZ L, PRIETO LA, BOYERO EC, DE MENDOZA S. Metformin in obesity associated with antipsychotic drug administration: a pilot study. J Clin Psychiatry. 2001 Aug;62(8):653-5.

138. BAPTISTA T, LACRUZ A, ANGELES F, SILVERA R, DE MENDOZA S, MENDOZA MT, HERNANDEZ L. Endocrine and metabolic abnormalities involved in obesity associated with typical antipsychotic drug administration. Pharmacopsychiatry. 2001 Nov;34(6):223-31.

139. BAPTISTA T, LACRUZ A, MEZA T, CONTRERAS Q, DELGADO C, MEJIAS MA, HERNANDEZ L. Antipsychotic drugs and obesity: is prolactin involved? Can J Psychiatry. 2001 Nov;46(9):829-34.

140. SILVA E, QUINONES B, FREUND N, GONZALEZ LE, HERNANDEZ L. Extracellular glutamate, aspartate and arginine increase in the ventral posterolateral thalamic nucleus during nociceptive stimulation. Brain Res. 2001 Dec 27;923(1-2):45-9.

141. PAEZ X AND HERNANDEZ L. Biomedical applications of capillary electrophoresis with laser –induced fluorescence detection. Biopharmaceutics and Drug Disposition. 2001 22: 273-289.

142. REYES E, ROSSELL S, PAREDES D, RADA P, TUCCI S, GONZALEZ LE, HERNANDEZ L. Haloperidol abolished glutamate release evoked by photic stimulation of the visual cortex in rats. Neurosci Lett. 2002 Jul 26;327(3):149-52.

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143. BAPTISTA T, LACRUZ A, PAEZ X, HERNANDEZ L, BEAULIEU S. The antipsychotic drug sulpiride does not affect bodyweight in male rats. Is insulin resistance involved? Eur J Pharmacol. 2002 Jun 28;447(1):91-8.

144. BAPTISTA T, LACRUZ A, DE MENDOZA D, MENDOZA JM, SILVERA R, ANGELES F, MENDOZA MT, HERNANDEZ L. Body weight gain after administration of antipsychotic drugs. Pharmacopsychiatry. 2002 Jan;35(1):36.

145. RADA P, MENDIALDUA A, HERNANDEZ L, HOEBEL B. Extracellular glutamate increases in the lateral hypothalamus during meal initiation, and GABA peaks during satiation: microdialysis measurements every 30 sec. Behav Neurosci. 2003 Apr;117(2):222-7.

146. PAEZ X, HERNANDEZ L Topical hemostatic effect of a common ornamental plant, the geraniaceae Pelargonium zonale. J Clin Pharmacol. 2003 Mar;43(3):291-5.

147. GONZALEZ LE, PARADA MA, TUCCI S, TENEUD L, OVERSTREET DH, HERNANDEZ L. A brain microdialysis study on 5-HT release in freely moving rat lines selectively bred for differential 5-HT1A receptor function. Braz J Med Biol Res. 2003 Feb;36(2):263-7

148. ROSSELL S, GONZALEZ LE, HERNANDEZ L. One-second time resolution brain microdialysis in fully awake rats. Protocol for the collection, separation and sorting of nanoliter dialysate volumes. J Chromatogr B Analyt Technol Biomed Life Sci. 2003 Feb 5;784(2):385-93.

149. LUENGO J, ARANGUIZ T, SEPULVEDA J, HERNANDEZ L, VON PLESSING C. Preliminary pharmacokinetic study of different preparations of acyclovir with beta-cyclodextrin. J Pharm Sci. 2002 Dec;91(12):2593-8.

150. RADA, P., MORENO, SA,, GONZALEZ, LE, TUCCI, S., CHAU, DT, HARRISON, T., HOEBEL, B.G. HERNÁNDEZ, L. Glutamate release in the nucleus accumbens is involved in behavioral depression during the Porsolt Swim Test. Neuroscience, 2003, 119: 557-565.

151. GONZALEZ LE, QUINONEZ B, RANGEL A, PINO S, HERNANDEZ L. Tonic and phasic alteration in amygdala 5-HT, glutamate and GABA transmission after prefrontal cortex damage in rats. Brain Res. 2004; 1005: 154-63.

152. PAEZ X, MAZZEI-DAVILA CA, HERNANDEZ L. Subcutaneous microdialysis: a simple technique for monitoring the extracellular biochemical environment. Combination with capillary electrophoresis and laser-induced fluorescence detection. Invest Clin. 2003;44: 227-39.

153. PAEZ X, HERNANDEZ L, BAPTISTA T. Advances in the molecular treatment of depression. Rev Neurol. 2003, 37:459-70.

154. RANGEL A, GONZALEZ LE, VILLARROEL V, HERNANDEZ L. Anxiolysis followed by anxiogenesis relates to coping and corticosterone after medial prefrontal cortical damage in rats. Brain Res. 2003 Nov 28;992(1):96-103.

155. SILVA E, HERNANDEZ L, QUINONEZ B, GONZALEZ LE, COLASANTE C. Selective amino acids changes in the medial and lateral preoptic area in the formalin test in rats. Neuroscience. 2004;124:395-404.

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156. BARBOZA JM, MEDINA H, DORIA M, RIVERO L, HERNANDEZ L, JOSHI NV. Use of atomic force microscopy to reveal sperm ultrastructure in HIV-patients on highly active antiretroviral therapy. Arch Androl. 2004; 50(2):121-9.

157. PAEZ X, MAZZEI-DAVILA CA, QUINONEZ B, D'SUZE G, HERNANDEZ L. Amino acid changes following intraperitoneal administration of Tityus zulianus scorpion venom in mice. Study with subcutaneous microdialysis and capillary electrophoresis. Invest Clin. 2003 ;44: 291-302.

158. BAPTISTA T, ZARATE J, JOOBER R, COLASANTE C, BEAULIEU S, PAEZ X, HERNANDEZ L. Drug Induced Weight Gain, an Impediment to Successful Pharmacotherapy: Focus on Antipsychotics. Current Drug Targets, 2004, 4:000-000

159. DIAZ-CORRALES FJ, COLASANTE C, CONTRERAS Q, PUIG M, SERRANO J-A, HERNANDEZ L, BEAMAN BL. Nocardia otitidiscaviarum (GAM-5) induces parkinsonian-like alterations in mouse. Braz J Med Biol Res. 2004, 37:000-000.

160. DMITRIEVA N, RODRIGUEZ-MALAVER AJ, PEREZ J, HERNANDEZ L. Differential release pf neurotransmitters from superficial and deep layers of the dorsal horn in response to acute noxious stimulation and inflamation of the rat paw. European J. Pain. 2003 (in press).

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CAPITULOS DE LIBROS 1.HERNANDEZ, L. Glucostatic influences on self-stimulationand hypothalamic

neurons. En: Brain Stimulation Reward. Editado por A. Wauquier & ET. Rolls. Publicado por North Holland Publishing Company. Impreso en Amsterdam, Holanda. New York, Elsevier. 1976.

2. HERNANDEZ, L., and BG. HOEBEL. Hypothalamic reward and aversion: A link between metabolism and behavior. En: The Hypothalamus: Current studies on hypothalamic

function. Vol. 2, Food and Water Intake. Reward and aversion. Metabolism and Behaviour. Editado por WL. Veale & K. Lederis. Publicado por Springer Verlag. Impreso en Karger, Basilea, Suiza. 1978. pp. 72-92.

3. HERNANDEZ, L., and BG. HOEBEL. Parallel increase in feeding and hypothalamic self-stimulation after midbrain 6-

hydroxydopamine, but no correlation of hyperphagia with norepinephrine depletion. En: Catecholamines: Basic and Clinical Frontiers. Editado por E. Vsdin, IJ. Kopin. 1978.

4. HERNANDEZ, L., and BG. HOEBEL. Basic mechanisms of feeding and weight reduction. AJ. Stunkard, ((Ed.), En: Obesity. WB. Saunders Company. Philadelphia, PA., EE.UU. 1980. pp. 25-47.

5. MONACO, A., L. HERNANDEZ and BG. HOEBEL. Nucleus accumbens: Site of amphetamine self-injection, comparison with lateral ventricle. En: The Neurobiology of the Nucleus Accumbens. Editado por RB. Chronister and J. DeFrance. Publicado por Frederick Haer Institute. Impreso en Brunswick, ME., EE.UU. 1981. pp. 338-342.

6. HOEBEL, BG., L. HERNANDEZ, S. MCLEAN, BG. STANLEY, EF. AULISSI, P. GLIMCHER and D. MARGOLIN. Catecholamines, enkephalin and neurotensin in feeding and reward. En: The Neural Basis of Feeding and Reward. Editado por BG. Hoebel & D. Novin. Publicado por Frederick Haer Institute. Impreso en Brunswick, ME., EE.UU. 1982. pp. 465-478.

7. HERNANDEZ, L., F. LEE, and BG. HOEBEL. Microdialysis in the mesolimbic system during feeding or treatment with amphetamine, cocaine, or phencyclidine. Kalivas PW, Nemeroff CB (Eds.) En: The Mesocorticolimbic Dopamine System. Ann. NY Acad Sci. 537: 1988. pp. 508-511.

8. SCHWARTZ, D., DORFMAN, D.B., HERNANDEZ, L. and HOEBEL, B.G. Cholecystokinin: 1. CCK antagonists in the PVN induce feeding. 2. Effects of

CCK in the nucleus accumbens on extracellular dopamine turnover. En el libro:

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Cholecystokinin Antagonists. Editado por R.Y. Wang. New York: Alan R. Liss, Inc. 1988.

9. GUZMAN, NA. and HERNANDEZ, L. A rapid procedure for the quantitative analysis of monoclonal antibodies by high performance capillary electrophoresis. Este artículo fue seleccionado para publicación en el libro The Protein Society de los Estados Unidos. 1988. En: Techniques in Protein Chemistry, editado por Tony E. Hugli, Academic Press, Inc. Harcourt Brace Jovanovich Publishers. 1989. pp. 456-467.

10. HOEBEL, BG., HERNANDEZ, L., MARK, G.P., SCHWARTZ, D.H., POTHOS, E., STECKEL, J.M. and STONE, E.A. Brain microdialysis as a molecular approach to obesity: Serotonin, Dopamine, Cyclic AMP. En: Obesity: Toward a Molecular Approach. G. Bray, D. Ricquier & B. Spiegleman (Eds.) UCLA Symposia. 1989.

11. HOEBEL, BG., HERNANDEZ, L., SCHWARTZ, D.H., MARK, G.P. and HUNTER, G.A. Microdialysis studies of brain norepinephrine, serotonin and dopamine release during ingestive behavior. Theoretical and Clinical Implications. En: The Psychobiology of Human Eating Disorders: Preclinical and Clinical Perspectives. LH. Schneider, SJ. Cooper & K.A. Halmi, (Eds.), Annals of the New York Academy of Sciences Vol. 575, New York Academy of Sciences, New York, N.Y., pp. 171-193. 1989.

12. GUZMAN, NA., HERNANDEZ, L. and ADVIS, J.P. Analysis of brain constituents by capillary electrophoresis. En: Current Research in Protein Chemistry: Techniques, Structure, and Function. Editado por J.J. Villafranca, Academic Press, Inc. Harcourt Brace Jovanovich, Publishers. NY, 1990.

13. HERNANDEZ, L., HOEBEL, BG., & GUZMAN, N.A. Analysis of cyclic nucleotides by capillary electrophoresis using ultraviolet detection. En C. Horvath & J.E. Nikelly (Eds.) Analytical Biotechnology:Capillary Electrophoresis and Chromatography. American Chemical Society Symposium Series 434, American Chemical Society, Washington, D.C., 1990, 50-59.

14. HERNANDEZ, L., MURZI, E., SCHWARTZ, D.H. and HOEBEL, B.G. Neuroelectrophysiological and neurochemical approach to a hierarchical feeding organization. En: Obesity, P. Bjorntorp & B. Brodoff, eds. J.B. Lippincott Co., Philadelphia, EE.UU. 1990.

15. HOEBEL, BG., and HERNANDEZ, L. New approaches to the neuropharmacology of appetite. En: S.J. Cooper & J. M. Liebman (Eds.), The Neuropharmacology of Appetite, Oxford Univ. Press, 1990. En prensa.

16. HOEBEL, BG., HERNANDEZ, L., MARK, G.P. and POTHOS, E. Microdialysis in the study of psychostimulants and the neural substrate of reinforcement: Focus on Dopamine and Serotonin. En: National Institute on Drug Abuse Research Monograph Series, 1990. En prensa.

17. HOEBEL, BG., HERNANDEZ, L., MARK, G.P., SCHWARTZ, D.H., POTHOS, E., STECKEL, J.M. and STONE, E.A. Brain microdialysis as a molecular approach to obesity: Serotonin, Dopamine, Cyclic-AMP. En: Obesity: Towards a Molecular Approach. GA. Bray, D. Ricquier & BM.

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Spiegelman (Eds.) UCLA Symposium on Molecular and Cellular Biology New Series, Vol. 132, Wiley-Liss Inc., New York, N.Y., pp. 45-61. 1990.

18. HOEBEL, BG., LEIBOWITZ, S.L. and HERNANDEZ, L. Neurochemistry of anorexia and bulemia. En H. Anderson (Ed.), The Biology of Feast and Famine: Relevance to Eating Disorders, Oxford University Press, 1990. En prensa.

19. HOEBEL, BG., MARK, G.P. and HERNANDEZ, L. Network hierarchy in brain control of feeding behavior. En: The Fifth IEEE International Symposium on Intelligent Control, pp. 67-70. 1990.

20. MARK, G. P., SCHWARTZ, D., HERNANDEZ, L. and HOEBEL, B.G. Microdialysis and behavior. En J.B. Justice & T.E. Robinson (Eds.), Microdialysis in the Neurosciences, Elsevier, 1990. En prensa.

21. HERNANDEZ, L., FERNANDEZ, R., PARADA, M., BAPTISTA, T., MURZI, E. and HOEBEL, B.G. Dopamine release in the dopaminergic system during feeding behavior. En: Monitoring Molecules in Neuroscience. Proceedings of the 5th International Conference on in vivo Methods. Eds.: Hans Rollema, Ben Westerink & Willem Jan Drijfhout. University Centre for Pharmacy, Groningen, Holanda. 1991. pp. 216-218.

22. HERNANDEZ, L., GUZMAN, N.A. & HOEBEL, BG. Local cocaine or

procaine, but not lidocaine, increase extracellular dopamine in the nucleus accumbens: cocaine microdialysis calibrated by capillary electrophoresis. En Problems of Drug Dependence 1990, National Institute on Drug Abuse Research Monograph Series. 1991. En prensa.

23. HOEBEL, B.G., LEIBOWITZ, S.F. and HERNANDEZ, L. Neurochemistry of anorexia and bulemia. En H. Anderson (ed.) The Biology of

Feast and Famine: Relevance to Eating Disorders. Oxford University Press, 1991. En preparación.

24. HOEBEL, B.G., SCHWARTZ, D., WEST, H.L., MARK, G.P. and HERNANDEZ, L.

Serotonine microdialysis in the hypothalamus during feeding, learned taste aversion, fluoxetine, fenfluramine and tryptophan. En: Monitoring Molecules in Neuroscience. Proceedings of the 5th International Conference on in vivo Methods. Eds.: Hans Rollema, Ben Westerink and Willem Jan Drijfhout. University Centre for Pharmacy, Groningen, Holanda. 1991. pp. 212-215.

25. TELLEZ, S., FORGES, N., ROUSSIN, A. and HERNANDEZ, L. Blood brain barrier permeability to phenobarbital as studied by dual

microdialysis coupled to capillary electrophoresis. En: Monitoring Molecules in Neuroscience. Proceedings of the 5th International Conference on in vivo Methods. Eds.: Hans Rollema, Ben Westerink and Willem Jan Drijfhout. University Centre for Pharmacy, Groningen, Holanda. 1991. pp. 122-124.

26. HERNANDEZ, L. and HOEBEL, B.G. Prospects for microdialysis and capillary electrophoresis. En: Microdialyse cérébrale: principes, interets et applications en biologie. Atelier 42. INSERM. Organisateurs: Stylanos Nicolaidis, Martine Orosco et Bernard Scatton. Le Vesinet, FRANCIA. 1992.

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27. HERNANDEZ, L., MURZI, E., SCHWARTZ, D.H. and HOEBEL, B.G. Electrophysiological and Neurochemical Approach to a Hierarchical Feeding Organization. En: P. Bjorntorp and B.N. Brodoff (Eds.) En: Obesity. Philadelphia J.B. Lippincott Co., 1992, Cap. 14, p. 171.

28. HOEBEL, B.G. and HERNANDEZ, L.Basic mechanisms of feeding and weight regulation. En: A.J. Stunkard (ed.) Obesity. Philadelphia, Saunders Co., 1992. En preparación.

29. HOEBEL, B.G., HERNANDEZ, L., MARK, G.P. and RADA, P. Microdialysis in the study of ingestive behavior. En: Microdialyse cérébrale: principes, interets et applications en biologie. Atelier 42. INSERM. Organisateurs: Stylanos Nicolaidis, Martine Orosco et Bernard Scatton. Le Vesinet, FRANCIA. 1992.

30. HOEBEL, B.G., MARK, G.P. and HERNANDEZ, L. New approaches to the neuropharmacology of appetite. En: The Neuropharmacology of Appetite, S.J. Cooper & J.M. Leibman (eds.) Oxford University Press. 1992. En prensa.

31. MARK, G.P., SCHWARTZ, D.H., HERNANDEZ, L., WEST, H.L. and HOEBEL, B.G. Application of microdialysis to the study of motivation and conditioning: Measurements of dopamine and Serotonin in freely-behaving rats. En: Microdialysis in the Neurosciences, (ed. T.E. Robinson and J. B. Justice), pp. XXX. Elsevier Science Publishing, Amsterdam. En prensa.

32. GUZMAN, N.A., GONZALEZ, C.L., HERNANDEZ, L., BERCK, C., TREBILCOCK, M.A. and ADVIS, J.P. The utility of Capillary Electrophoresis in Clinical Diagnosis. En: Capillary Electrophoresis: Theory, Methodology, and Applications. N.A. Guzman, Editor. 1993.

33. HERNANDEZ, L., VERDEGUER, P., GUZMAN, N.A. and JOSHI, N. Laser-induced fluorescence detection for capillary electrophoresis: a powerful analytical tool for the separation and detection of trace amounts of analytes. Chap. 19. En: Capillary Electrophoresis: Theory, Methodology, and Applications. N.A. Guzman, Editor. 1993. pp. 605-614.

34. HOEBEL, B.G., P. RADA, G.P. MARK, M. PARADA, M.PUIG DE PARADA, E. POTHOS, L. HERNANDEZ. Hypothalamic control of accumbens dopamine: a system for feeding reinforcement. En: Molecular and Genetic Aspects of Obesity. Capitulo. En prensa.

35. HOEBEL, B.G., P. RADA, G.P. MARK, AND L. HERNANDEZ. The power of integrative peptides to reinforce behavior by releasing dopamine. En: Neuropeptides, past, present and future. Annals of The New York Acad. Sci.

36. PAEZ, X. y L. HERNANDEZ. Microdiálisis intracerebral. En: Manual de Neurociencia. Universidad de Sevilla, España. 1996.

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