cancer signaling poster - microsoft · 2018. 4. 6. · apoptosis pro-apoptotic factors mw...

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Y our Expertise, Our Antibodies, Accelerated 1 a 1 r a [r ìI'f1 ll l'l | Growth Factor I ; Reorganization . . . . . . . . . . . . . . . . . . . . . . . .... heatAdhesion g Disassembly CP ............................ 2.............................. Autophagolvsosome : Growth factors qq Q-.;J •• Degrades upon mTOR activation . . . . . . . . . . . . . . . ........................................................................................................................ ( mTOR elF4E Protein Synthesis rd ' .. T a M IAP Repression Bid e nE a m E3 HH-EE--'EU A N D ............ . . TRAIL . VEGF Dendritic Ce ll Ca 2 + .._ •••• Ca 2 • .: 2 • • J •• . Permeability Galectin9 ••• CD80 or CD86 ‘•- Gl " . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . E •••• . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . DNA fragmentation Condensation nE n hu e- -m-m hb hm dne .. ........ ........ ERSt ..... ... Ca 2+ J Ca lpain, DNA repair failure sp2 7.: TNFa TNFa FasL G2 .................................................................................................................................................................................... - L D P 2 nu p z C H M e g TC a M s :x:x.'J< . . . . . . . . . . . . . . . .................................................................................................................................................................................... . . . x rx.'X x^- 'J< X^- 'X Angiogenesis XXX XXX XXX Metastasis :x:x:x: Glucose .......... ........................................................................................................................................................... |I Odí ..1 1 d :atJ U :t3 :01.] 1 dlSi f. . E 1' l.t.)36. GeneTex PP-C002-171221 : 1.949.309 .2888 USA Tel: 1.949.553.1900 Email : info @genetex.com Fax International Tel : 886.3.6208988 Fax: 886.3.6208989 Email : international@genetex.com genetex www

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Page 1: Cancer Signaling poster - Microsoft · 2018. 4. 6. · Apoptosis Pro-Apoptotic Factors MW 且"-(岫a)-... 油凶神糊糊 FADD BcI-2 體二 55 43-34-26 17-Casoases 25-的- 恤闡明明3

Y our Expertise, Our Antibodies, Accelerated DiscoveηT •

• 1 a

• 1 r a

[r ìI'f1ll l'l u'il削m; 建起三

| Growth Factor E哩,回回四Enm宣噩噩,

I ; Reorganization

: : 、:::::::::::::::姆

. . . . ~.......................... . . . . . . . . . . . . . . . . . . .

.... .~tJ<..........

~也

heatAdhesion g Disassembly

αP

CP

均勻。

…M。

m............................2..............................

Autophagolvsosome

: Growth factors

- f訊 :qq

0...1:在,_

Q-.;J

•• .主.

、吋Degrades upon

mTOR activation

. . . . . . . . . . . . . . . •........................................................................................................................

G~L

TORCI 咆~

(mTOR

哇竺ZE

elF4E Protein Synthesis B配linl

rd

' ..

TaM IAP Repression

Bid

e nE a m E3 HH-EE--'EU 可dp

A N D

............ . .

TRAIL. VEGF

Dendritic Cell

Ca2+ .._ _..三

Ca2+ 勻."..- 吋•••• Ca2

• .: • 2

. N。毛←吧多}←些丘, 吋抖,• • J •• •

.

Permeability

Galectin9 ••• CD80

or CD86

‘•-

Gl

"

. .. .. .. .. .. .. .. .. .. .. .. .. .. .. .. .. .. .. .. .. .. .. .. .. ..

E •••• . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . .

DNA fragmentation

Chron可oson可e

Condensation

nE n 』u

hu

e­啊,叫

此隨

-m-m hb hm dne 。"于

.. ........ ........ ......晶晶........................................................................................................................................................................................

ERSt

~~. ~ ‘..... ... .~ Ca2+

J Calpain,

DNA repair failure

.Hsp40~

sp27.:

TNFa

TNFa

FasL

G2

.................................................................................................................................................................................... 一﹒

-L D P

2 B』

nu p z C H M

e g e

悶u時

自叫

TC a M

s :x:x.'J<

. . . . . . . . . . . . . . . .................................................................................................................................................................................... . . .

心↓…

xrx.'X

x^-'J< X^-'X

Angiogenesis

XXX

XXX XXX •

Metastasis

:x:x:x: )0(χxχx

Glucose metabolisn、

。σ ο

..........• ........................................................................................................................................................... | IOdí ..11 d:atJ U:t3 :01.] 1 dlSi f. . E回E團團團E 1'l.t.)36.

~ 也,

丸L、t

GeneTex PP-C002-171221

、可

回.回

舖: 1.949 .309 .2888 USA Tel: 1.949.553 .1900 Email : [email protected]

Fax

International Tel : 886.3.6208988 Fax: 886 .3.6208989 Email : [email protected] co 盯1genetex www

Page 2: Cancer Signaling poster - Microsoft · 2018. 4. 6. · Apoptosis Pro-Apoptotic Factors MW 且"-(岫a)-... 油凶神糊糊 FADD BcI-2 體二 55 43-34-26 17-Casoases 25-的- 恤闡明明3

Hypoxia Hypoxia-induced Factors (HIFs)

MW ____!:但坦-一1kOa) _ - _ '_ ~,酬的屯肉?

170

130

100

HIF1 alpha

HIF Deqradation

Von Hippel Lindau

HIF Taraet Genes

CAIX

HIF1 alpha

PHD1

c-Met

Autophagy

SQSTM1 (p62) NDP52

ATG12 LC3B

( " 、D細' 1 注~' ~玲、cþ'j" {kMDWaivJ 嗯O? 可.~.p

lil: 95 -72-55 一一

-間118日-

‘2叫43- 130-

34-

26 95

Beclin 1 ULK1

HIF1 beta

PHD2

HDAC3

ATG5

FIP200

,-MW

(kDa) ...!! 咱河.",啊呻.,叫

35 25

15 - .-... .•. 3咄10

LC3B

Immune Checkpoints

MW 且L(kDJ) 斗干甜甜訓-如

130 95 -72-

PD-L 1 PD-L 1

MW 坦全坐監釘4你 Da) ~ 知"~I'1 TI前-市陶

180 _ 1J[} -95 72 -55 43-

34

26

心叫山

PD-L 1

Cell Cycle

HIF2 alpha P21 Cip1 p27 Kip1

CDKs and Cyclins

PHD4 CDK4 CDK6

Cell Cycle Regulators

EPO Rb PLK1

Growth Factor

GABARAPL 1 EGFR EGFR (phospho Tyrl 068)

mTORSi r

h MDW ai Ezm +血叩吐E耳的個 ~~~ ~且:t;恥L (kDa) .:....:.. t制 uMCCCP. 2 r<

IBC

250 ﹒司_ rn l OO年k耳封回世"...... 1"

13C

180 95-

130 72

LC3A mTOR (phospho Ser244日) Raptor (phospho Ser792)

VEGF Si9naling

--、 ,----MW

W川 ("肌0,肉)!?udb (1岫70a)tt r (kDa)

130- 語55 =

: I 自180 -

100-130

211670 -- 油市7日 _=_ JATC一一1 95 -72

55 55-

40

ATG16L1 VEGF VEGF Receptor 2/FLK1

PD-L 1 PDl PD-L2 CD40

p53 (phospho Ser15) Chk1 (phospho Ser317)

Cyclin El Cyclin D1

[ri yrbeuF τJJSA6ZJH3tPAdFL EVIJ祉:~,也、較"謹.、-

Aurora A Wee1

EGFR (phospho Tyrl173) DAG1

' r MW…=ι品已晶晶晶間:_lOJ t.

( k D a i -- +- - + T1 EE 兩r刮4 月目EEZRmfdcEmm ikMDWa)E-比起~且 5耐叫f'!lG:_t , rrir.

130 - 180 -10700 -- 130 - _

55 95 -40 72

I -:_ OOf.>>;:蟬祖圖冊35- 55 -

25 一 43

PRAS40 (phospho Ser183) AKT (phospho Ser473)

﹒冒 ﹒』且- ~ 毛_ . .... - .:且~壘,冒圖-~-圖~ •

eNOS (phospho Serll77) TIE2

CD27

Apoptosis Pro-Apoptotic Factors

MW 且"-(岫a ) - ... 油凶神糊糊

FADD

BcI-2

體二55 43-34-

26

17-

Casoases

25 -

的 - 恤闡明明3

10

Caspase 3

---、

TRADD

Bcl-X

,--(kMDW a) J-MM + 1D MME耶岫圳

72 一站三

17

10-

Caspase 7

Cell Migration Focal Adhesion

Paxillin FAK (phospho Tyr576)

Epithelial-Mesenchymal Transition

Bax Cytochrome C

HSP90 Survivin

,-- 『、 r一

ikMDW aIEHBι+- ZMM曲回" ' 悅刪Da) 。a、"心.' 1 認三 !對三

95 一72 -

43 - - '_ c呻扭曲55

43 34 2月5- 34

Caspase 8 Caspase 12

Zyxin alpha Actinin

E-Cadherin N-Cadherin Vimentin Alpha Smooth Muscle Actin

-VASP ROCK1 Talin Arp2

每每 GeneTexwww.genetex.com

Tel : 886.3.6208988 Fax: 886.3.6208989

Email: [email protected] Tel: 1.949.553.1900 Fax: 1.949.309.2888

Email : [email protected] 露自www.genelexωm