cancer renal
TRANSCRIPT
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CANCER RENALDr. Daniel Amaro MedranoMedico Especialista en Medicina InternaAsistente del HRMNBJefe del Departamento de Medicina del HRMNB
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CLASIFICACIN DE LA OMS
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HIPERNEFROMASinnimos : Carcinoma de clulas claras Adenocarcinoma renal Tumor de grawitz
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EPIDEMIOLOGIALos carcinomas del parnquima renal son los ms frecuentes en la edad adulta.
Representan un 2.3% de las neoplasias malignas del adulto.
La incidencia anual en EEUU es aproximadamente de 28.000 nuevos casos ao.
El cncer renal tiene una incidencia levemente superior en la raza blanca.
Ms frecuente en varones con una relacin 3:1 respecto a las mujeres y afecta ms a poblaciones urbanas que a comunidades rurales.
En el 80% de los casos la enfermedad aparecer entre los 50 y 70 aos de edad con un pico mximo de incidencia en la sexta dcada de la vida.
Tiene un crecimiento lento y es casi siempre unilateral (98%)
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Incidencia con el tiempoSource Cancer Research UK
Chart1
187511507.06929379323.3662183394
194212427.23807530383.5283013944
210512457.80743821833.5679451718
221813108.2183225043.7055387029
226013908.21500813713.8938365968
234014048.57771364163.9761442305
240514908.70447741084.1036795452
233914528.44891287444.0382550826
248815618.92804213884.2808439063
258116359.19231599814.4651499755
2864166910.06932819384.5586955431
2850179510.03485188594.8170482786
2885181810.00766618994.9682884985
3062187010.50705730215.00127222
3130185910.6360666524.8940271577
3282201211.1606468025.3971705999
3194206110.7937462735.34044503
3307208710.96560574395.5573502015
3533220911.62497604325.8214668154
Males Numbers
Females Numbers
Males DAS(E)
Females DAS(E)
Numbers of new cases
Rate per 100,000
Kidney cancer incidence, numbers of newly diagnosed cases and directly age standardised rates (European) per 100,000 population
Lung
19791980198119821983198419851986198719881989199019911992199319941995199619971979198019811982198319841985198619871988198919901991199219931994199519961997
Males Numbers31128310213133631204309723030531589296682953229363284652798927946280732653926255253392423923876
Females Numbers949999831066011027111741161212515123081301413280131801326213570141731388214126143171415314112
Males DAS(E)113.9005944195112.264201597112.2294646318111.0493248131108.7907773519106.6159006388109.9884573095102.4971966906101.0974977848100.193335070896.194187818693.921330928691.971578860392.263524557285.6304393385.203764259881.269605643677.102843742575.0245292496
Females DAS(E)26.985948595727.957434938729.534598510330.132517055330.330548998231.385234457833.276550341832.394041072134.277062470634.635996643934.108974373334.32878706634.501162071235.619645834834.790022762135.271871160735.361555739435.217431710834.8100080661
Lung
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&A
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Males Numbers
Females Numbers
Males DAS(E)
Females DAS(E)
Number of new cases per year
Rate per 100,000
Incidence of lung cancer, numbers of new cases and directly age standardised (European) rates per 100,000, Great Britain, 1979-1997
Breast
1979198019811982198319841985198619871988198919901991199219931994199519961997
Numbers23715249562501225725256282592528129279452923929743313443215234251351193366034824351573566136841
DAS(E)74.772367428678.511551988578.021076281480.383056606179.059896568379.710049944385.695531474285.587521374888.677210417489.974961666295.047263493398.7345390854105.536881518107.6163311942101.8143269341104.5660265488104.71777776105.6714336081108.8473800322
Breast
00
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00
00
00
00
00
00
00
00
00
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&A
Page &P
Numbers
DAS(E)
Numbers of newly diagnosed cases
Rate per 100,000 population
Female breast cancer incidence, numbers of newly diagnosed cases and directly age standardised (European) rates per 100,000, Great Britain, 1979-1997
colorectal
19791980198119821983198419851986198719881989199019911992199319941995199619971979198019811982198319841985198619871988198919901991199219931994199519961997
Males Numbers12464127851325313327136841387414400139591453014849152221539615552164911649916432159251697516680
Females Numbers13649139851465114575147341462615103149151536615493156371547615513162211562115740152201629515569
Males DAS(E)46.895156148947.691683722349.050071659948.710371698749.386596323749.858303566450.999014509649.045641154750.793503448651.370453147652.145970537452.468437724451.890748178555.094259226653.964245175553.837723448251.593424557254.625537059252.8559204175
Females DAS(E)35.036964358235.396316113736.808453026236.51437064336.515633039235.648930976336.682848184536.209645925236.649913956536.687514710636.569687059736.233876194736.128146349137.491401034136.254644048736.318107436134.566351825637.247141008135.3624842254
colorectal
0000
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0000
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&A
Page &P
Males Numbers
Females Numbers
Males DAS(E)
Females DAS(E)
Numbers of new cases
Rate per 100,000
Colorectal cancer incidence, numbers of newly diagnosed cases and directly age standardised rates (European) per 100,000 population
prostate
1979198019811982198319841985198619871988198919901991199219931994199519961997
Numbers935398441029210669111451143112325125681308313799140681469115645171291892721186210982214221303
DAS(E)39.00598544940.266788550741.266285229842.223806645243.444564890544.065975666946.614418648746.632827363848.072620414350.248876948350.550019198352.195197854654.727742078359.279869664165.033515236672.178875061371.303127134274.143699424370.7364811277
prostate
00
00
00
00
00
00
00
00
00
00
00
00
00
00
00
00
00
00
00
Numbers
DAS(E)
Numbers of newly diagnosed cases
Rate per 100,000 population
Prostate cancer incidence, numbers of newly diagnosed cases and directly age standardised (European) rates per 100,000 males, Great Britain, 1979-1997
bladder
19791980198119821983198419851986198719881989199019911992199319941995199619971979198019811982198319841985198619871988198919901991199219931994199519961997
Males Numbers7231742777237742802582528622845587859179897092119185947795019506953792138721
Females Numbers2759281430442995311831703374347234913695376436063660388038443707387636753718
Males DAS(E)29.638807521829.894928080431.009260176530.784013160231.553974425632.167908757333.275863125432.363117498933.352662592334.691099307133.587727575834.229614705333.627131640734.164200397934.047487007733.72712517933.430728554631.880136022129.8109405808
Females DAS(E)7.14376984887.21901524927.79653025777.63445160397.89175365147.92550031238.32795771228.53411921898.3982640988.88099272669.08208756798.3680778568.5110154978.88917233498.95778835978.27776601548.73347352688.22653287578.2231054808
bladder
0000
0000
0000
0000
0000
0000
0000
0000
0000
0000
0000
0000
0000
0000
0000
0000
0000
0000
0000
Males Numbers
Females Numbers
Males DAS(E)
Females DAS(E)
Numbers of new cases
Rate per 100,000
Bladder cancer incidence, numbers of newly diagnosed cases and directly age standardised rates (European) per 100,000 population
Stomach
19791980198119821983198419851986198719881989199019911992199319941995199619971979198019811982198319841985198619871988198919901991199219931994199519961997
Males Numbers7812818780867963807177077970782574587648737070666870701765566733648162946349
Females Numbers5470534255625364529252075282486050864784475444124442433740394021394937253846
Males DAS(E)29.070969411630.150837727929.377911580628.655158947928.681839675627.365455272628.005862854327.197075212425.825193923426.069343528925.055653870523.746612582322.639439474623.172771646121.033142558821.759179913920.796603430319.876467992119.9970237386
Females DAS(E)13.24823778512.767805550313.113207228512.485229183712.194019834511.971507285611.805541921110.806906909311.39204986610.407614402510.20971728499.46196138749.43691046389.11678059868.51022229718.54637146888.29215005827.86335961018.1011058556
Stomach
0000
0000
0000
0000
0000
0000
0000
0000
0000
0000
0000
0000
0000
0000
0000
0000
0000
0000
0000
Males Numbers
Females Numbers
Males DAS(E)
Females DAS(E)
Numbers of new cases
Rate per 100,000
Stomach cancer incidence, numbers of newly diagnosed cases and directly age standardised rates (European) per 100,000 population
NHL
19791980198119821983198419851986198719881989199019911992199319941995199619971979198019811982198319841985198619871988198919901991199219931994199519961997
Males Numbers2059215022042316246626512866297933083469354137833884406741154261406841494205
Females Numbers1750193820522093224623712663267928663221327331783454354036523751356836263739
Males DAS(E)7.72063690818.06408324888.28974091048.59336744069.15173737349.722071344210.398915273110.765055078411.945573120312.452373001812.458652028513.325277948813.395473622514.051750961614.050216023814.57893158713.672602431213.865527126613.8853000719
Females DAS(E)5.11414429085.53373519365.86758942785.93806404556.40836538526.64423383557.39809260027.41096380357.88312561688.74785341728.81358106868.66118356539.26414691429.49780199849.660728863310.07306896639.4104696769.52051597819.7469654367
NHL
0000
0000
0000
0000
0000
0000
0000
0000
0000
0000
0000
0000
0000
0000
0000
0000
0000
0000
0000
Males Numbers
Females Numbers
Males DAS(E)
Females DAS(E)
Numbers of new cases
Rate per 100,000
Non-Hodgkin's Lymphoma incidence, numbers of newly diagnosed cases and directly age standardised rates (European) per 100,000 population
oesophagus
19791980198119821983198419851986198719881989199019911992199319941995199619971979198019811982198319841985198619871988198919901991199219931994199519961997
Males Numbers2279246325862673262527552919301032013324331434773519372638503979394940114142
Females Numbers1889193120842105209121882216216223572390248225032561269326812777272426902710
Males DAS(E)8.5424451089.1597424279.4281323219.69848240379.50539702299.864462246510.327828446610.629220498711.243440024811.617492348511.420796745711.913951258911.847223562712.575158272112.70184232413.216132856612.93559082613.05810973413.2838918019
Females DAS(E)4.73789457024.78194943415.12527874265.12747846285.03104359025.23289823185.14296331785.03406898985.38955013865.42862210865.68618634295.56507736115.67698360055.96634113895.87588651456.1011216115.92000860545.79340659875.8259731385
oesophagus
0000
0000
0000
0000
0000
0000
0000
0000
0000
0000
0000
0000
0000
0000
0000
0000
0000
0000
0000
Males Numbers
Females Numbers
Males DAS(E)
Females DAS(E)
Numbers of new cases
Rate per 100,000
Oesophageal cancer incidence, numbers of newly diagnosed cases and directly age standardised rates (European) per 100,000 population
Ovary
1979198019811982198319841985198619871988198919901991199219931994199519961997
Numbers4795502050725123535753555580549757735736573657045922594458775941625764086674
DAS(E)14.959462371715.745133541515.811893987315.874799987516.413197067316.372298079116.91988574816.677851247317.43961610617.237259925217.128003699116.833955728217.632260187117.553778732117.065605724117.150533369317.984992009118.373685394119.0168817553
Ovary
00
00
00
00
00
00
00
00
00
00
00
00
00
00
00
00
00
00
00
Numbers
DAS(E)
Numbers of newly diagnosed cases
Rate per 100,000 population
Ovarian cancer incidence, numbers of newly diagnosed cases and directly age standardised (European) rates per 100,000, Great Britain, 1979-1997
Pancreas
19791980198119821983198419851986198719881989199019911992199319941995199619971979198019811982198319841985198619871988198919901991199219931994199519961997
Males Numbers3412332033413319335633593405329732773353325833583347334432403116313631913174
Females Numbers3147315131843310325732623509341734763474359535073542355234773502343434613379
Males DAS(E)12.96511536412.304008776112.252722844912.054275180512.065113866112.069302104711.951996173211.588696747411.412454639811.601075519211.087735225111.408185588911.122195663411.195708468510.579575278710.25051195410.274615871410.349498000910.0747905433
Females DAS(E)7.88941159397.83451745047.71991670358.0015458537.85666974727.75952166778.2069071117.95430015618.15901154647.96922485248.32330184198.03566363017.98716739827.92728732587.84691506537.78768906367.66769597877.66714094947.4424623919
Pancreas
0000
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0000
0000
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0000
0000
0000
0000
0000
0000
0000
0000
0000
0000
0000
Males Numbers
Females Numbers
Males DAS(E)
Females DAS(E)
Numbers of new cases
Rate per 100,000
Pancreatic cancer incidence, numbers of newly diagnosed cases and directly age standardised rates (European) per 100,000 population
leukaemia
19791980198119821983198419851986198719881989199019911992199319941995199619971979198019811982198319841985198619871988198919901991199219931994199519961997
Males Numbers2580256026802788278628413080277829643197312331703308322033343392360233463371
Females Numbers2064213122622300245224532615239026142717268926152592267527672845287727712765
Males DAS(E)9.89375825099.662721090510.054925009910.357223722610.267604095510.388710866811.17521888459.972182852710.566680311311.294693032111.016214451211.021162113311.280412759110.937800862511.070008081111.367268260611.948853088410.998719035611.0586130125
Females DAS(E)5.92901331945.9587303276.19652212026.31621996.75774901546.70203245996.99975136596.40467513696.96863901077.08603913217.04545208396.887683296.69402040226.88058328457.07458290777.33132868937.35473983767.10564782377.0433296165
leukaemia
0000
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0000
0000
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0000
0000
0000
0000
0000
0000
0000
0000
0000
0000
0000
0000
0000
Males Numbers
Females Numbers
Males DAS(E)
Females DAS(E)
Numbers of new cases
Rate per 100,000
Leukaemia incidence, numbers of newly diagnosed cases and directly age standardised rates (European) per 100,000 population
Kidney
19791980198119821983198419851986198719881989199019911992199319941995199619971979198019811982198319841985198619871988198919901991199219931994199519961997
Males Numbers1875194221052218226023402405233924882581286428502885306231303282319433073533
Females Numbers1150124212451310139014041490145215611635166917951818187018592012206120872209
Males DAS(E)7.06929379327.23807530387.80743821838.2183225048.21500813718.57771364168.70447741088.44891287448.92804213889.192315998110.069328193810.034851885910.007666189910.507057302110.63606665211.16064680210.79374627310.965605743911.6249760432
Females DAS(E)3.36621833943.52830139443.56794517183.70553870293.89383659683.97614423054.10367954524.03825508264.28084390634.46514997554.55869554314.81704827864.96828849855.001272224.89402715775.39717059995.340445035.55735020155.8214668154
Kidney
Males Numbers
Females Numbers
Males DAS(E)
Females DAS(E)
Numbers of new cases
Rate per 100,000
Kidney cancer incidence, numbers of newly diagnosed cases and directly age standardised rates (European) per 100,000 population
Melanoma
19791980198119821983198419851986198719881989199019911992199319941995199619971979198019811982198319841985198619871988198919901991199219931994199519961997
Males Numbers7567988628759749591267128714691767161517011679185921222130217122132366
Females Numbers1444154116251746189919042313234625852829269625062560282531663191326931713243
Males DAS(E)2.92005424293.08708590233.30554078623.37141877453.66736886013.62128615694.76322706034.80545349445.42942014786.46505846415.90887603716.1535837886.00290553386.5916959017.46646836657.46039327147.44790459347.52963560417.9962222477
Females DAS(E)4.88002613915.1430062755.44179243945.79880231446.27338031376.26730344747.77879605067.64490696728.40312367499.11669792158.55156150267.82106252077.87962902848.60114345169.69895594599.67284593179.92105898149.55111380779.6881764842
Melanoma
0000
0000
0000
0000
0000
0000
0000
0000
0000
0000
0000
0000
0000
0000
0000
0000
0000
0000
0000
Males Numbers
Females Numbers
Males DAS(E)
Females DAS(E)
Numbers of new cases
Rate per 100,000
Melanoma skin cancer incidence, numbers of newly diagnosed cases and directly age standardised rates (European) per 100,000 population
Uterus
1979198019811982198319841985198619871988198919901991199219931994199519961997
Numbers4237433043874372438544354490436143794535450244994544467646414760451346044748
DAS(E)12.770291588613.032447876813.094473523813.027257341213.118763232313.23800064513.337776022512.907037838512.845411373213.288093091213.211640285313.110438266313.114384984313.509591009913.3295009613.52119114412.850414424713.049180677313.5326893151
Uterus
00
00
00
00
00
00
00
00
00
00
00
00
00
00
00
00
00
00
00
Numbers
DAS(E)
Numbers of newly diagnosed cases
Rate per 100,000 population
Cancer of the uterus incidence, numbers of newly diagnosed cases and directly age standardised (European) rates per 100,000, Great Britain, 1979-1997
Lip and mouth
19791980198119821983198419851986198719881989199019911992199319941995199619971979198019811982198319841985198619871988198919901991199219931994199519961997
Males Numbers2166211321352283227022292288226323002420230723922556262925882728273528282810
Females Numbers1453136614641437151814871503140415041508149315721562163315901670168517081860
Males DAS(E)8.34541574438.03101210748.05730072758.55845587668.43722363728.27312366688.43698444258.26190701518.38542416468.79112404718.34320950358.61311275539.02591544049.28184423799.0129074349.53600049469.49727007919.77489354979.56021405
Females DAS(E)4.16965335643.8228707034.16591482024.09749067384.2203517054.20311793954.24664643383.89711113044.19042643084.24024306384.15238787334.39187611134.33644630564.5743668224.46315193464.59660204574.7526520264.80105232565.2134579675
Lip and mouth
0000
0000
0000
0000
0000
0000
0000
0000
0000
0000
0000
0000
0000
0000
0000
0000
0000
0000
0000
Males Numbers
Females Numbers
Males DAS(E)
Females DAS(E)
Numbers of new cases
Rate per 100,000
Lip and mouth skin cancer incidence, numbers of newly diagnosed cases and directly age standardised rates (European) per 100,000 population
Brain
19791980198119821983198419851986198719881989199019911992199319941995199619971979198019811982198319841985198619871988198919901991199219931994199519961997
Males Numbers1529153616061559162417031765170318471867192119081971210520482071197019102050
Females Numbers1144119912131170125413221348128813331486150014351473163616181617156015901490
Males DAS(E)5.81798125065.8078421026.08049852845.86616080416.09195204666.43354214046.60187528356.38646742516.87800120016.85541660617.03657884226.994472537.09482458747.56182740867.23449224627.27560463226.8410615466.63426832717.0188421969
Females DAS(E)3.94108646844.00609251624.07875222973.98287910724.24414802654.42951936124.44619623134.25759592224.39872396284.88834004254.86844291174.71699132544.82213251635.14555683355.08956013394.97511328494.82968860094.84313124554.5623232127
Brain
0000
0000
0000
0000
0000
0000
0000
0000
0000
0000
0000
0000
0000
0000
0000
0000
0000
0000
0000
Males Numbers
Females Numbers
Males DAS(E)
Females DAS(E)
Numbers of new cases
Rate per 100,000
Brain cancer incidence, numbers of newly diagnosed cases and directly age standardised rates (European) per 100,000 population
cervix
1979198019811982198319841985198619871988198919901991199219931994199519961997
Numbers4293446445434349441145704840480047704940456547354095380036903536337233193146
DAS(E)14.689801974415.211246827615.514725134714.751841627814.946527508915.514551319316.444160310116.216002577915.966279435816.59255714414.991639349315.661876729113.322735101812.101861290611.756194592911.124035821110.472231939310.28650331789.7735896863
cervix
00
00
00
00
00
00
00
00
00
00
00
00
00
00
00
00
00
00
00
Numbers
DAS(E)
Numbers of newly diagnosed cases
Rate per 100,000 population
Cervical cancer incidence, numbers of newly diagnosed cases and directly age standardised (European) rates per 100,000, Great Britain, 1979-1997
males
19791980198119821983198419851986198719881989199019911992199319941995199619971979198019811982198319841985198619871988198919901991199219931994199519961997
Lung31128310213133631204309723030531589296682953229363284652798927946280732653926255253392423923876
Colorectal12464127851325313327136841387414400139591453014849152221539615552164911649916432159251697516680
Prostate935398441029210669111451143112325125681308313799140681469115645171291892721186210982214221303
Stomach7812818780867963807177077970782574587648737070666870701765566733648162946349
Bladder7231742777237742802582528622845587859179897092119185947795019506953792138721
Pancreas3412332033413319335633593405329732773353325833583347334432403116313631913174
Leukaemia2580256026802788278628413080277829643197312331703308322033343392360233463371
Oesophagus2279246325862673262527552919301032013324331434773519372638503979394940114142
Lip and mouth2166211321352283227014872288226323002420230723922556262925882728273528282810
NHL2059215022042316246626512866297933083469354137833884406741154261406841494205
Kidney1875194221052218226023402405233924882581286428502885306231303282319433073533
Brain and CNS1529153616061559162417031765170318471867192119081971210520482071197019102050
Melanoma7567988628759749591267128714691767161517011679185921222130217122132366
19791980198119821983198419851986198719881989199019911992199319941995199619971979198019811982198319841985198619871988198919901991199219931994199519961997
Lung113.9005944195112.264201597112.2294646318111.0493248131108.7907773519106.6159006388109.9884573095102.4971966906101.0974977848100.193335070896.194187818693.921330928691.971578860392.263524557285.6304393385.203764259881.269605643677.102843742575.0245292496
Colorectal46.895156148947.691683722349.050071659948.710371698749.386596323749.858303566450.999014509649.045641154750.793503448651.370453147652.145970537452.468437724451.890748178555.094259226653.964245175553.837723448251.593424557254.625537059252.8559204175
Prostate39.00598544940.266788550741.266285229842.223806645243.444564890544.065975666946.614418648746.632827363848.072620414350.248876948350.550019198352.195197854654.727742078359.279869664165.033515236672.178875061371.303127134274.143699424370.7364811277
Stomach29.070969411630.150837727929.377911580628.655158947928.681839675627.365455272628.005862854327.197075212425.825193923426.069343528925.055653870523.746612582322.639439474623.172771646121.033142558821.759179913920.796603430319.876467992119.9970237386
Bladder29.638807521829.894928080431.009260176530.784013160231.553974425632.167908757333.275863125432.363117498933.352662592334.691099307133.587727575834.229614705333.627131640734.164200397934.047487007733.72712517933.430728554631.880136022129.8109405808
Pancreas12.96511536412.304008776112.252722844912.054275180512.065113866112.069302104711.951996173211.588696747411.412454639811.601075519211.087735225111.408185588911.122195663411.195708468510.579575278710.25051195410.274615871410.349498000910.0747905433
Leukaemia9.89375825099.662721090510.054925009910.357223722610.267604095510.388710866811.17521888459.972182852710.566680311311.294693032111.016214451211.021162113311.280412759110.937800862511.070008081111.367268260611.948853088410.998719035611.0586130125
Oesophagus8.5424451089.1597424279.4281323219.69848240379.50539702299.864462246510.327828446610.629220498711.243440024811.617492348511.420796745711.913951258911.847223562712.575158272112.70184232413.216132856612.93559082613.05810973413.2838918019
Lip and mouth8.34541574438.03101210748.05730072758.55845587668.43722363728.27312366688.43698444258.26190701518.38542416468.79112404718.34320950358.61311275539.02591544049.28184423799.0129074349.53600049469.49727007919.77489354979.56021405
NHL7.72063690818.06408324888.28974091048.59336744069.15173737349.722071344210.398915273110.765055078411.945573120312.452373001812.458652028513.325277948813.395473622514.051750961614.050216023814.57893158713.672602431213.865527126613.8853000719
Kidney7.06929379327.23807530387.80743821838.2183225048.21500813718.57771364168.70447741088.44891287448.92804213889.192315998110.069328193810.034851885910.007666189910.507057302110.63606665211.16064680210.79374627310.965605743911.6249760432
Brain and CNS5.81798125065.8078421026.08049852845.86616080416.09195204666.43354214046.60187528356.38646742516.87800120016.85541660617.03657884226.994472537.09482458747.56182740867.23449224627.27560463226.8410615466.63426832717.0188421969
Melanoma2.92005424293.08708590233.30554078623.37141877453.66736886013.62128615694.76322706034.80545349445.42942014786.46505846415.90887603716.1535837886.00290553386.5916959017.46646836657.46039327147.44790459347.52963560417.9962222477
Numbers and rates for the major cancer sites in men (Great Britain)
197919891997
siteNumberDAS(E)siteNumberDAS(E)rank in 1979siteNumberDAS(E)rank in 1979
1Lung31128113.90Lung2846596.191Lung2387675.021
2Colorectal1246446.90Colorectal1522252.152Prostate2130370.743
3Prostate935339.01Prostate1406850.553Colorectal1668052.862
4Stomach781229.07Bladder897033.595Bladder872129.815
5Bladder723129.64Stomach737025.064Stomach634920.004
6Pancreas341212.97NHL354112.4610NHL420513.8910
7Leukaemia25809.89Oesophagus331411.428Oesophagus414213.288
8Oesophagus22798.54Pancreas325811.096Kidney353311.6211
9Lip and mouth21668.35Leukaemia312311.027Leukaemia337111.067
10NHL20597.72Kidney286410.0711Pancreas317410.076
11Kidney18757.07Lip and mouth23078.349Lip and mouth28109.569
12Brain and CNS15295.82Brain and CNS19217.0412Melanoma23668.0013
13Melanoma7562.92Melanoma16155.9113Brain and CNS20507.0212
males
0000000000000
0000000000000
0000000000000
0000000000000
0000000000000
0000000000000
0000000000000
0000000000000
0000000000000
0000000000000
0000000000000
0000000000000
0000000000000
0000000000000
0000000000000
0000000000000
0000000000000
0000000000000
0000000000000
Lung
Colorectal
Prostate
Stomach
Bladder
Pancreas
Leukaemia
Oesophagus
Lip and mouth
NHL
Kidney
Brain and CNS
Melanoma
Number of new cases reported
Incidence trends (numbers) in major cancer sites for males, 1979-1997
females
0000000000000
0000000000000
0000000000000
0000000000000
0000000000000
0000000000000
0000000000000
0000000000000
0000000000000
0000000000000
0000000000000
0000000000000
0000000000000
0000000000000
0000000000000
0000000000000
0000000000000
0000000000000
0000000000000
Lung
Colorectal
Prostate
Stomach
Bladder
Pancreas
Leukaemia
Oesophagus
Lip and mouth
NHL
Kidney
Brain and CNS
Melanoma
Rate per 100,000
Directly age standardised incidence rates (European) for the major sites, men in Great Britain 1979-1997
19791980198119821983198419851986198719881989199019911992199319941995199619971979198019811982198319841985198619871988198919901991199219931994199519961997
Breast23715249562501225725256282592528129279452923929743313443215234251351193366034824351573566136841
Colorectal13649139851465114575147341462615103149151536615493156371547615513162211562115740152201629515569
Lung949999831066011027111741161212515123081301413280131801326213570141731388214126143171415314112
Ovary4795502050725123535753555580549757735736573657045922594458775941625764086674
Uterus4237433043874372438544354490436143794535450244994544467646414760451346044748
Stomach5470534255625364529252075282486050864784475444124442433740394021394937253846
NHL1750193820522093224623712663267928663221327331783454354036523751356836263739
Bladder2759281430442995311831703374347234913695376436063660388038443707387636753718
Pancreas3147315131843310325732623509341734763474359535073542355234773502343434613379
Melanoma1444154116251746189919042313234625852829269625062560282531663191326931713243
Cervix4293446445434349441145704840480047704940456547354095380036903536337233193146
Leukaemia2064213122622300245224532615239026142717268926152592267527672845287727712765
Oesophagus1889193120842105209121882216216223572390248225032561269326812777272426902710
Kidney1150124212451310139014041490145215611635166917951818187018592012206120872209
Lip and mouth1453136614641437151814871503140415041508149315721562163315901670168517081860
Brain and CNS1144119912131170125413221348128813331486150014351473163616181617156015901490
19791980198119821983198419851986198719881989199019911992199319941995199619971979198019811982198319841985198619871988198919901991199219931994199519961997
Breast74.772367428678.511551988578.021076281480.383056606179.059896568379.710049944385.695531474285.587521374888.677210417489.974961666295.047263493398.7345390854105.536881518107.6163311942101.8143269341104.5660265488104.71777776105.6714336081108.8473800322
Colorectal35.036964358235.396316113736.808453026236.51437064336.515633039235.648930976336.682848184536.209645925236.649913956536.687514710636.569687059736.233876194736.128146349137.491401034136.254644048736.318107436134.566351825637.247141008135.3624842254
Lung26.985948595727.957434938729.534598510330.132517055330.330548998231.385234457833.276550341832.394041072134.277062470634.635996643934.108974373334.32878706634.501162071235.619645834834.790022762135.271871160735.361555739435.217431710834.8100080661
Ovary14.959462371715.745133541515.811893987315.874799987516.413197067316.372298079116.91988574816.677851247317.43961610617.237259925217.128003699116.833955728217.632260187117.553778732117.065605724117.150533369317.984992009118.373685394119.0168817553
Cervix14.689801974415.211246827615.514725134714.751841627814.946527508915.514551319316.444160310116.216002577915.966279435816.59255714414.991639349315.661876729113.322735101812.101861290611.756194592911.124035821110.472231939310.28650331789.7735896863
Stomach13.24823778512.767805550313.113207228512.485229183712.194019834511.971507285611.805541921110.806906909311.39204986610.407614402510.20971728499.46196138749.43691046389.11678059868.51022229718.54637146888.29215005827.86335961018.1011058556
Uterus12.770291588613.032447876813.094473523813.027257341213.118763232313.23800064513.337776022512.907037838512.845411373213.288093091213.211640285313.110438266313.114384984313.509591009913.3295009613.52119114412.850414424713.049180677313.5326893151
Pancreas7.88941159397.83451745047.71991670358.0015458537.85666974727.75952166778.2069071117.95430015618.15901154647.96922485248.32330184198.03566363017.98716739827.92728732587.84691506537.78768906367.66769597877.66714094947.4424623919
Bladder7.14376984887.21901524927.79653025777.63445160397.89175365147.92550031238.32795771228.53411921898.3982640988.88099272669.08208756798.3680778568.5110154978.88917233498.95778835978.27776601548.73347352688.22653287578.2231054808
Leukaemia5.92901331945.9587303276.19652212026.31621996.75774901546.70203245996.99975136596.40467513696.96863901077.08603913217.04545208396.887683296.69402040226.88058328457.07458290777.33132868937.35473983767.10564782377.0433296165
NHL5.11414429085.53373519365.86758942785.93806404556.40836538526.64423383557.39809260027.41096380357.88312561688.74785341728.81358106868.66118356539.26414691429.49780199849.660728863310.07306896639.4104696769.52051597819.7469654367
Melanoma4.88002613915.1430062755.44179243945.79880231446.27338031376.26730344747.77879605067.64490696728.40312367499.11669792158.55156150267.82106252077.87962902848.60114345169.69895594599.67284593179.92105898149.55111380779.6881764842
Oesophagus4.73789457024.78194943415.12527874265.12747846285.03104359025.23289823185.14296331785.03406898985.38955013865.42862210865.68618634295.56507736115.67698360055.96634113895.87588651456.1011216115.92000860545.79340659875.8259731385
Lip and Mouth4.16965335643.8228707034.16591482024.09749067384.2203517054.20311793954.24664643383.89711113044.19042643084.24024306384.15238787334.39187611134.33644630564.5743668224.46315193464.59660204574.7526520264.80105232565.2134579675
Brain and CNS3.94108646844.00609251624.07875222973.98287910724.24414802654.42951936124.44619623134.25759592224.39872396284.88834004254.86844291174.71699132544.82213251635.14555683355.08956013394.97511328494.82968860094.84313124554.5623232127
Kidney3.36621833943.52830139443.56794517183.70553870293.89383659683.97614423054.10367954524.03825508264.28084390634.46514997554.55869554314.81704827864.96828849855.001272224.89402715775.39717059995.340445035.55735020155.8214668154
197919891997
Rank 1979siteNumberDAS(E)siteNumberDAS(E)rank in 1979siteNumberDAS(E)rank in 1979
1Breast2371574.7723674286Breast3134495.04726349331Breast36841108.84738003221
2Colorectal1364935.0369643582Colorectal1563736.56968705972Colorectal1556935.36248422542
3Lung949926.9859485957Lung1318034.10897437333Lung1411234.81000806613
4Stomach547013.248237785Ovary573617.12800369915Ovary667419.01688175535
5Ovary479514.9594623717Stomach475410.20971728494Uterus474813.53268931517
6Cervix429314.6898019744Cervix456514.99163934936Stomach38468.10110585564
7Uterus423712.7702915886Uterus450213.21164028537NHL37399.746965436712
8Pancreas31477.8894115939Bladder37649.08208756799Bladder37188.22310548089
9Bladder27597.1437698488Pancreas35958.32330184198Pancreas33797.44246239198
10Leukaemia20645.9290133194NHL32738.813581068612Melanoma32439.688176484214
11Oesophagus18894.7378945702Melanoma26968.551561502614Cervix31469.77358968636
12NHL17505.1141442908Leukaemia26897.045452083910Leukaemia27657.043329616510
13Lip and mouth14534.1696533564Oesophagus24825.686186342911Oesophagus27105.825973138511
14Melanoma14444.8800261391Kidney16694.558695543115Kidney22095.821466815415
15Kidney11503.3662183394Brain and CNS15004.868442911716Lip and mouth18605.213457967513
16Brain and CNS11443.9410864684Lip and mouth14934.152387873313Brain and CNS14904.562323212716
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Breast
Colorectal
Lung
Ovary
Uterus
Stomach
NHL
Bladder
Pancreas
Melanoma
Cervix
Leukaemia
Oesophagus
Kidney
Lip and mouth
Brain and CNS
Number of new cases reported
Incidence trends (numbers) in the major cancer sites for females, 1979-1997, Great Britain
0000000000000
0000000000000
0000000000000
0000000000000
0000000000000
0000000000000
0000000000000
0000000000000
0000000000000
0000000000000
0000000000000
0000000000000
0000000000000
0000000000000
0000000000000
0000000000000
0000000000000
0000000000000
0000000000000
Ovary
Uterus
Stomach
NHL
Bladder
Pancreas
Melanoma
Cervix
Leukaemia
Oesophagus
Kidney
Lip and mouth
Brain and CNS
Number of new cases reported
Incidence trends (numbers) in the major cancer sites for females, 1979-1997, Great Britain
0000000000000000
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Breast
Colorectal
Lung
Ovary
Cervix
Stomach
Uterus
Pancreas
Bladder
Leukaemia
NHL
Melanoma
Oesophagus
Lip and Mouth
Brain and CNS
Kidney
Rate per 100,000 population
Directly age standardised incidence rates (European) for the major sites, women in Great Britain, 1979-1997
Ovary
Cervix
Stomach
Uterus
Pancreas
Bladder
Leukaemia
NHL
Melanoma
Oesophagus
Lip and Mouth
Brain and CNS
Kidney
Rate per 100,000 population
Directly age standardised incidence rates (European) for the major sites, women in Great Britain, 1979-1997
-
DISTRIBUCION POR EDADESSource BAUS 2001
Distribution of cases
67.16443.461
222.33697.458
458.568238.377
715.644396.417
662.376383.247
189.912159.357
Male
Female
Number of cases
Sheet1
MaleFemaleMaleFemale
/= 808.212.123161317189.912159.357
Sheet2
Sheet3
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FACTORES DE RIESGOCarcter familiar/genticoVon Hippel-Lindau 3p25Tabaquismo ObesidadHipertensin arterialTxicos ambientalesDilisisRadiacinFenacetinaExposicin a sustancias qumicas industriales
-
MANIFESTACIONES CLINICASTrada clsica
HEMATURIA (60%) DOLOR (45%) MASA PALPABLE (35%)
-
MANIFESTACIONES CLINICAS
Gran simuladorTUMOR DEL INTERNISTAOTRAS PRESENTACIONES Fiebre Perdida de peso Sntomas digestivos Anorexia, Anemia Neuropatas perifricas Hipertensin arterial Hipercalcemia Hipoglucemia Sndrome de Cushing Sindromes paraneoplasicosDisfuncin heptica
-
ANATOMIA PATOLOGICAOrigen en las clulas epiteliales del tbulo contorneado proximal
Inicio seudocpsula fibrosa capsula renal> crecimiento invade grasa perineal metastatiza a ganglios regionales
pulmn > fciaMetstasis a distancia hgado esqueleto cerebro
-
La angiognesis es un factor indispensable en el desarrollo y metstasis del cncer renal, ya que el tratamiento actual del cncer renal metasttico est dirigido hacia la inhibicin de este proceso biolgicoEste tumor depende de la angiognesis para su progresin
-
DIAGNOSTICOSospecha clnicaEcografa Alta sensibilidad TAC EstadificacinRNMLa arteriografa En desuso Solo en duda acerca de si el tumor es renal o metastsico.Biopsia
-
TRATAMIENTOQUIRRGICONefrectoma radicalNefrectoma parcial
RADIOTERAPIA Poco efectiva
QUIMIOTERAPIA Resistente a frmacos citotxicos
INMUNOTERAPIAInterferon, interleukina
Inhibidores de kinasasSorafenidSunitinid
-
TRATAMIENTOAnti-angiogenesisBAY 43-9006 (Sorafenib)RapamycinBevacizumab (Avastin)SU011248
-
NEFROBLASTOMATumor de WilmsTumor de origen embrionarioGrado de curacin del 85%INCIDENCIA7.8/milln de nios < 15Tumor solid abdominal mas fcte5ta lesin maligna de la infanciaForma hereditaria 15 a 20% bilateralPromedio de edad 2.5 aosNias ligeramente mas afectadasAsociaciones con aniridia, hemihipertrofia, disgenesia gonadal y retraso mental.
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ANATOMIA PATOLOGICATamao variable10% son multicentricosPresentaHemorragia intratumoralNecrosisConstituido por clulas epiteliales forman tbulo o glomrulos embrionarios rodeados de un estroma de clulas fusiformes.
PulmonMetstasis higado ganglios linfanticosVena renal trombos
-
MANIFESTACIONES CLINICASMasa abdominal palpable (90%)Hematuria (25%)Fiebre (18%)Dolor abdominalHipertensin
-
DIAGNOSTICORadiografia simpleUrografiaEcografiaTACDIAGNOSTICO DIFERENCIAL
QuistesTumor de Bolande
-
ESTADIAJE
Estadio ITumor limitado a rinEstadio IISe extiende ms all de rin pero es resecadoEstadio IIITumor residual en abdomen (ganglios +, afectacin peritoneal, margen + o irresecableEstadio IVMetstasis a distanciaEstadio VBilateral
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TRATAMIENTODepender del estadio en que se encuentre.CombinaExresis del tumorRadioterapiaQuimioterapia
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GRACIAS